Healers & Therapists News

Healers & Therapists News

Healers & Therapists News from June Meagher of AAMARHealing brings you the latest news from sources such as the BBC Health pages as well as the Green Med Info pages and Science Daily, we will be adding more news feeds shortly. Join the conversations on our LinkedIn group which has over 18,000 healers and therapists from around the globe and discover even more news and tips. If you have any news you would like to add to our website, please contact me and I can add it to our blog.

 

    • BBC News - Health
    • GreenMedInfo
    • Latest Science News -- ScienceDaily

    Prof Dame Sarah Gilbert says medical science has transformed ambitions for new vaccines. Read more

    Explore the data on coronavirus in the UK and find out how many cases there are in your area. Read more

    People share their stories of having negative PCR tests after positive lateral flow results. Read more

    A lab in Wolverhampton is suspended as 43,000 people in England and Wales are potentially affected. Read more

    Some people who took tests in Berkshire earlier this month may have wrongly been given the all-clear. Read more

    The figures come despite improving numbers overall, with some 610 fewer stillbirths in 2019 than in 2013. Read more

    It comes as ministers unveil £250m package for GPs to encourage more face-to-face consultations. Read more

    Lateral flow tests are more accurate than first thought, according to new research. Read more

    The Westminster and Cardiff governments have set out their plans to deal with Covid this winter. Read more

    Positive results from the widely-used rapid Covid tests should be trusted, say UCL researchers. Read more

    Henrietta Lacks was an African-American woman whose cells have led to key medical breakthroughs. Read more

    The World Health Organization unveils a new group to examine the emergence of the virus more closely. Read more

    Doctors who came into the public eye during Covid received death threats and harassment. Read more

    A lack of care staff in the community leaves hospitals struggling to discharge patients. Read more

    The app widely used to prove vaccination status for travel suffered an outage Wednesday. Read more

    Face coverings could become a legal requirement in England again if the NHS struggles this winter. Read more

    More than two million people in England have had a third booster dose of Covid vaccine. Read more

    One of England's leading hospitals is preparing for its busiest winter ever. Read more

    It is alarming, say researchers, that longevity was declining in the north even before the pandemic. Read more

    The treatment, meant to rejuvenate and treat dryness, worked no better than a placebo procedure. Read more

    "Dementia is something you learn to live with, not just die of," - tips from, those living with the condition. Read more

    The vaccine is being offered to children aged 12 and older. Read more

    The former England rugby player speaks to those living with the same condition as his father. Read more

    But the new report by MPs fails to reflect the views of bereaved relatives, campaigners say. Read more

    Some of the Tesco Max All-In-One Chesty Cough & Cold Lemon Sachets contain incorrect dosing information. Read more

    There have been calls for an independent public inquiry into the UK's pandemic response to start immediately. Read more

    NHS England says the number of pregnant women seriously ill in critical care with the virus has grown. Read more

    As African countries get the vaccine, Newsbeat speaks to two people who've grown up with Malaria. Read more

    Pre-workout powders should be diluted in water, but some gym-goers are eating it neat. Read more

    Following the announcement about the first malaria vaccine, we look at some of the key questions. Read more

    The number of people with secondary breast cancer, where the cancer has spread, will be audited. Read more

    Tedros Adhanom Ghebreyesus says the vaccine could save tens of thousands of lives each year. Read more

    A new cough, fever and change in smell or taste are the key symptoms of coronavirus. Read more

    All children aged 12-15 across the UK are being offered one dose of the Pfizer vaccine. Read more

    Vegan alternatives have never been more widespread, but are they a healthier option? Read more

    BBC journalist Gem O'Reilly explains the risk of exercise-related death in people with unknown heart conditions. Read more

    Fraternal twins Evan and Lizzy are enroled in Pfizer's vaccine trial for children between ages five and 11. Read more

    A non-surgical technique to remove stubborn fat from the body can have side effects. Read more

    All over-12s in the UK will be able to get at least one Covid jab. Read more

    UK coronavirus cases are rising due to a variant first identified in India that spreads more easily. Read more

    - greenmedinfo

    PMID:  Bioengineered. 2021 Sep 30. Epub 2021 Sep 30. PMID: 34592881 Abstract Title:  Berberine inhibited carotid atherosclerosis through PI3K/AKTmTOR signaling pathway. Abstract:  Atherosclerosis, a multifactorial vascular disease resulting from lipid metabolism disorders, features chronic inflammatory damage resulting from endothelial dysfunction, which usually affects multiple arteries. The carotid artery is a common site for clinical atherosclerosis evaluation. The aortic root is the standard site for quantifying atherosclerosis in mice. Due to the adverse reactions of first-line drugs, it is necessary to discover new drugs to prevent and treat atherosclerosis. Berberine (BBR) is one of the most promising natural products derived from herbal medicine(Huanglian) that features significant anti-atherosclerosis properties. However, overall BBR mechanism against carotid atherosclerosis has not been clearly discovered. Our work aimed to investigate potential BBR mechanism in improving carotid atherosclerosis in ApoE knockout mice. Here, we proved that in ApoEmice receiving high-fat diet for 12 weeks, BBR can reduce serum lipid levels, improve intimal hyperplasia, and antagonize carotid lipid accumulation, which may be achieved through regulating the PI3K/AKT/mTOR signaling pathway, regulating autophagy, promoting cell proliferation and inhibiting cell apoptosis. In summary, these data indicate that BBR can ameliorate carotid atherosclerosis. Therefore, it could be a promisingly therapeutic alternative for… Read more

    - greenmedinfo

    PMID:  Eur J Pharmacol. 2021 Sep 29 ;911:174526. Epub 2021 Sep 29. PMID: 34599914 Abstract Title:  Remodelling of gut microbiota by Berberine attenuates trimethylamine N-oxide-induced platelet hyperreaction and thrombus formation. Abstract:  Berberine is an extract derived from Chinese herbs with pleiotropic cardiovascular protective effects. However, the underlying mechanism remains unclear because of its poor bioavailability. Herin, we aimed to investigate whether berberine affects choline diet-induced arterial thrombosis and explore the potential mechanism. Ultrasound and optical coherence tomography were used to assess the potential risk of artery thrombosis in vivo. The plasma concentrations of trimethylamine N-oxide (TMAO) and trimethylamine (TMA) were quantified with mass spectrometry. Enzyme-linked immunosorbent assay (ELISA) and quantitative real-time polymerase chain reaction (qPCR) were utilized to detect the levels of microbial TMA-lyase choline utilization C (CutC) in faeces. Gut microbiota analysis was performed with 16S rRNA gene sequencing. For in vitro studies, platelet aggregometry, intracellular Cameasurement, ATP release assay, flow cytometry and Western blot were applied to identify the effects of TMAO on platelets. Berberine treatment significantly decreased the CutC levels in the caecal contents, reduced choline diet-induced TMA and TMAO production, and subsequently, reduced the arterial thrombosis potential risk. Berberine administration remodelled the structure of gut microbiota… Read more

    - greenmedinfo

    PMID:  BMC Pharmacol Toxicol. 2021 10 3 ;22(1):54. Epub 2021 Oct 3. PMID: 34600570 Abstract Title:  Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model. Abstract:  BACKGROUND: Berberine (BBR) is a plant alkaloid that possesses anti-inflammatory and anti-oxidant effects with low oral bioavailability. In this study, micelle formulation of BBR was investigated to improve therapeutic efficacy and examined its effect on the secretion of inflammatory cytokines in cerebral ischemia in the animal model.MATERIAL AND METHODS: Nano formulation was prepared by thin-film hydration method, and characterized by particle size, zeta potential, morphology, encapsulation efficacy, and drug release in Simulated Gastric Fluid (SGF) and Simulated Intestine Fluid (SIF). Then, Wistar rats were pretreated with the drug (100 mg/kg) and nano-drug (25, 50, 75, 100 mg/kg) for 14 days. Then, on the fourteenth day, stroke induction was accomplished by Bilateral Common Carotid Artery Occlusion (BCCAO); after that, Tumor Necrosis Factor - Alpha (TNF-α), Interleukin - 1 Beta (IL-1ß), and Malondialdehyde (MDA) levels were measured in the supernatant of the whole brain, then the anti-inflammatory effect of BBR formulations was examined.RESULT AND DISCUSSION: Micelles were successfully formed with appropriate characteristics and smaller sizes than… Read more

    - greenmedinfo

    PMID:  Front Pharmacol. 2021 ;12:750826. Epub 2021 Sep 17. PMID: 34603061 Abstract Title:  Berberine Alleviates Non-alcoholic Steatohepatitis Through Modulating Gut Microbiota Mediated Intestinal FXR Activation. Abstract:  Berberine is a natural plant alkaloid isolated from a diverse range of genera, it obtains anti-inflammatory, anti-obesity, and hepatoprotective properties, and is a promising agent for non-alcoholic steatohepatitis (NASH). Farnesoid X receptor (FXR) is a bile acid receptor and a drug target for NASH, however, the underlying mechanisms of berberine on regulating FXR are still unknown. In the present study, we feed mice with a 12-week high-fat diet with interval dextran sulfate sodium (0.5% in drinking water) diet to induce NASH, and treat the mice with berberine (100 mg/kg per day)oral gavage for additional 4 weeks. We demonstrate that administration of berberine alleviates steatosis and infiltration of inflammatory cells in the liver of NASH mice. We apply 16S ribosomal DNA sequencing to screen the structure of gut microbiota, and ultra-performance liquid chromatography-tandem mass spectrometry analysis to determine the bile acid profiles. The results show that berberine modulates gut dysbiosis, and specifically increases the relative abundance of,and. Berberine modulated microbiomes are associated with bile acid de-conjugation and transformation, which are consistent with the altered bile acid species… Read more

    - greenmedinfo

    PMID:  J Food Biochem. 2021 Oct 5:e13954. Epub 2021 Oct 5. PMID: 34609010 Abstract Title:  Berberine loaded liquid crystalline nanostructure inhibits cancer progression in adenocarcinomic human alveolar basal epithelial cells in vitro. Abstract:  Metastasis represents the leading cause of death in lung cancer patients. C-X-C Motif Chemokine Ligand 8 (CXCL-8), Chemokine (C-C motif) ligand 20 (CCL-20) and heme oxygenase -1 (HO-1) play an important role in cancer cell proliferation and migration. Berberine is an isoquinoline alkaloid isolated from several herbs in the Papaveraceae family that exhibits anti-inflammatory, anticancer and antidiabetic properties. Therefore, the aim of present study is to investigate the inhibitory potential of berberine monoolein loaded liquid crystalline nanoparticles (berberine-LCNs) against cancer progression. Berberine-LCNs were prepared by mixing berberine, monoolein and poloxamer 407 (P407) using ultrasonication method. A549 cells were treated with or without 5 µM dose of berberine LCNs for 24 hr and total cellular protein was extracted and further analyzed for the protein expression of CCl-20, CXCL-8 and HO-1 using human oncology array kit. Our results showed that berberine-LCNs significantly reduced the expression of CCl-20, CXCL-8 and HO-1 at dose of 5µM. Collectively, our findings suggest that berberine-LCNs have inhibitory effect on inflammation/oxidative stress related cytokines i.e. CCL20, CXCL-8,… Read more

    - greenmedinfo

    PMID:  Eur J Drug Metab Pharmacokinet. 2021 Oct 12. Epub 2021 Oct 12. PMID: 34635990 Abstract Title:  Pharmacokinetics and Pharmacodynamics of Huanglian-Houpo Decoction Based on Berberine Hydrochloride and Magnolol Against H1N1 Influenza Virus. Abstract:  BACKGROUND AND OBJECTIVES: Huanglian-Houpo decoction (HH), which is recorded in the famous traditional Chinese medicine monograph "Puji Fang," contains two individual herbs, Huanglian (Rhizoma coptidis) and Houpo (Magnoliae officinalis cortex). It was regularly used to treat seasonal epidemic colds and influenzas in ancient China. Our laboratory discovered that HH has a significant anti-H1N1 influenza virus effect. However, no pharmacokinetic and pharmacodynamic data concerning the anti-H1N1 influenza virus activity of HH are available to date. In the current study, the concentration-time profiles of two major components of HH, berberine and magnolol, in rat plasma were investigated.METHODS: An integrate pharmacokinetic approach was developed for evaluating the holistic pharmacokinetic characteristics of berberine and magnolol from HH. Additionally, the inhibition rate and levels of IFN-β in MDCK cells infected by influenza virus were analyzed. Data were calculated using 3p97 with pharmacokinetic analysis.RESULTS: The estimated pharmacokinetic parameters were maximum plasma concentration (C) 0.9086μg/ml, area under the concentration-time curve (AUC) 347.74 μg·min/ml, and time to reach C(T) 64.69 min for berberine and C=… Read more

    - greenmedinfo

    PMID:  Front Pharmacol. 2021 ;12:720866. Epub 2021 Sep 22. PMID: 34630099 Abstract Title:  Berberine Potentiates Insulin Secretion and Preventsβ-cell Dysfunction Through the miR-204/SIRT1 Signaling Pathway. Abstract:  Pancreaticβ-cell dysfunction is a key link during the progression of type 2 diabetes (T2DM), and SIRT1 participates in the regulation of various physiological activities of islet β-cells. However, as a key link in signal transduction, it is not clear how SIRT1 is regulated. By TargetScan prediction, we found that miR-204, which is enriched in islets, has highly complementary binding sites with SIRT1. Therefore, we speculate that miR-204 may be the upstream regulatory target of SIRT1 in islets and thus participate in the occurrence of β-cell dysfunction. In this study, we explored the association between miR-204 and β-cell dysfunction, the therapeutic effects of berberine (BBR) on β-cell function and the possible mechanisms. We found that miR-204 increased and SIRT1 mRNA and protein levels decreased significantly in islets bothand. MIN6 cells induced by palmitic acid exhibited increased apoptosis, and the accumulation of insulin and ATP in the supernatant decreased. Importantly, palmitic acid treatment combined with miR-204 silencing showed opposite changes. MiR-204 overexpression in MIN6 cells increased apoptosis and decreased insulin and ATP production and SIRT1 expression.… Read more

    - greenmedinfo

    PMID:  Oncol Rep. 2021 Dec ;46(6). Epub 2021 Oct 13. PMID: 34643248 Abstract Title:  Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway. Abstract:  Glucose transporter 1 (GLUT1) plays a primary role in the glucose metabolism of cancer cells. However, to the best of our knowledge, there are currently no anticancer drugs that inhibit GLUT1 function. The present study aimed to investigate the antineoplastic activity of berberine (BBR), the main active ingredient innumerous Traditional Chinese medicinal herbs, on HepG2 and MCF7 cells. The results of Cell Counting Kit‑8 assay, colony formation assay and flow cytometry revealed that BBR effectively inhibited the proliferation of tumor cells, and induced G/M cell cycle arrest and apoptosis. Notably, the results of luminescence ATP detection assay and glucose uptake assay showed that BBR also significantly inhibited ATP synthesis and markedly decreased the glucose uptake ability, which suggested that the antitumor effect of BBR may occur via reversal of theWarburg effect. In addition, the results of reverse transcription‑quantitative PCR, western blotting and immunofluorescence staining indicated that BBR downregulated the protein expression levels of GLUT1, maintained the cytoplasmic internalization of GLUT1 and suppressed the Akt/mTOR signaling pathway in both HepG2 and… Read more

    - greenmedinfo

    PMID:  Int J Mol Sci. 2021 Oct 6 ;22(19). Epub 2021 Oct 6. PMID: 34639164 Abstract Title:  Potential Effects of Sweet Potato () in Hyperglycemia and Dyslipidemia-A Systematic Review in Diabetic Retinopathy Context. Abstract:  Hyperglycemia is a condition with high glucose levels that may result in dyslipidemia. In severe cases, this alteration may lead to diabetic retinopathy. Numerous drugs have been approved by officials to treat these conditions, but usage of any synthetic drugs in the long term will result in unavoidable side effects such as kidney failure. Therefore, more emphasis is being placed on natural ingredients due to their bioavailability and absence of side effects. In regards to this claim, promising results have been witnessed in the usage of() in treating the hyperglycemic and dyslipidemic condition. Thus, the aim of this paper is to conduct an overview of the reported effects offocusing on in vitro and in vivo trials in reducing high glucose levels and regulating the dyslipidemic condition. A comprehensive literature search was performed using Scopus, Web of Science, Springer Nature, and PubMed databases to identify the potential articles on particular topics. The search query was accomplished based on the Boolean operators involving keywords such as (1) Beneficial… Read more

    - greenmedinfo

    PMID:  Plant Foods Hum Nutr. 2021 Sep 28. Epub 2021 Sep 28. PMID: 34581915 Abstract Title:  Hypoglycemic and Vasorelaxant Effect of Passiflora edulis Fruit Peel By-Product. Abstract:  Passiflora edulis fo. flavicarpa (Passifloraceae) is popularly known as yellow passion fruit and its fruit peels are considered a rich by-product in bioactive compounds which has greatly beneficial health properties. The objective of this study was to evaluate the effects of P. edulis fruit peel extracts in a type 1 diabetes model and the potential vasorelaxant effect. The aqueous and hydroethanolic extracts were obtained from P. edulis fruit peels and orientin and isorientin flavonoids were identified in both extracts through ultra-high performance liquid chromatography. Pectin was only identified in the aqueous extract by high-performance steric exclusion chromatography and nuclear magnetic resonance. Regarding the vascular system, the hydroethanolic extract showed better vasorelaxant effects in the mesenteric artery rings when compared to the aqueous extract. These effects mainly occur by opening the potassium channels. In the type 1 diabetes model, extracts at doses of 400 and 600 mg/kg were able to restore the effect of insulin in diabetic rats which were not responding to its action. The antidiabetic effect was more significant for the aqueous extract.… Read more

    - greenmedinfo

    PMID:  Molecules. 2021 Jun 15 ;26(12). Epub 2021 Jun 15. PMID: 34203815 Abstract Title:  Boswellic Acids Show In Vitro Activity against. Abstract:  In continuation of our search for leads from medicinal plants against protozoal pathogens, we detected antileishmanial activity in polar fractions of a dichloromethane extract fromresin. 11-keto-β-boswellic acid (KBA) could be isolated from these fractions and was tested in vitro againstaxenic amastigotes along with five further boswellic acid derivatives. 3--acetyl-11-keto-β-boswellic acid (AKBA) showed the strongest activity with an ICvalue of 0.88µM against axenic amastigotes but was inactive against intracellular amastigotes in murine macrophages. read more Read more

    - greenmedinfo

    PMID:  Antibiotics (Basel). 2021 Jul 15 ;10(7). Epub 2021 Jul 15. PMID: 34356781 Abstract Title:  Antibacterial Activity ofFlueck. Oleoresin Extract againstPeriodontal Pathogen. Abstract:  Flueck. oleoresin extract (frankincense) has traditionally been used in the treatment of different diseases, but there are no sufficient studies on its potential activity against periodontal pathogens. Therefore, antibacterial and antibiofilm activity of frankincense extract againstclinical isolates were studied. The phytochemical composition of the volatile components of the extract was identified by GC-MS analysis revealing 49 compounds as-nerolidyl formate, cycloartenol acetate, ursenoic acid 3-oxomethyl ester, bisabolene epoxide, and kaur-16-ene. It decreased the growth and increased the leakage of nucleotides in 58.3% and 33.3% of isolates, respectively. Additionally, it reduced the extracellular polysaccharide production and the cell surface hydrophobicity in 41.67% and 50% of the isolates, respectively. Crystal violet assay revealed inhibition of biofilm formation by the tested isolates. Light microscope and scanning electron microscope were used to examine the biofilms and they confirmed the reduction of biofilm formation by frankincense extract. Downregulation of the genes linked to biofilm formation (A,A, andB) was observed using qRT-PCR after treatment with the frankincense extract. This study suggested that the frankincense extract could exhibit antibacterial and antibiofilm activity againstisolates. Thus, the… Read more

    - greenmedinfo

    PMID:  Pharmaceuticals (Basel). 2021 Jul 10 ;14(7). Epub 2021 Jul 10. PMID: 34358086 Abstract Title:  Analysis of Boswellic Acid Contents and Related Pharmacological Activities of Frankincense-Based Remedies That Modulate Inflammation. Abstract:  Extracts of frankincense, the gum resin ofspecies, have been extensively used in traditional folk medicine since ancient times and are still of great interest as promising anti-inflammatory remedies in Western countries. Despite their common therapeutic use and the intensive pharmacological research including studies on active ingredients, modes of action, bioavailability, pharmacokinetics, and clinical efficacy, frankincense preparations are available as nutraceuticals but have not yet approved as a drug on the market. A major issue of commercially available frankincense nutraceuticals is the striking differences in their composition and quality, especially related to the content of boswellic acids (BAs) as active ingredients, mainly due to the use of material from divergentspecies but also because of different work-up and extraction procedures. Here, we assessed three frequently used frankincense-based preparations for their BA content and the interference with prominent pro-inflammatory actions and targets that have been proposed, that is, 5-lipoxygenase and leukotriene formation in human neutrophils, microsomal prostaglandin Esynthase-1, and inflammatory cytokine secretion in human blood monocytes. Our data reveal striking differences in… Read more

    - greenmedinfo

    PMID:  J Egypt Natl Canc Inst. 2021 Aug 9 ;33(1):20. Epub 2021 Aug 9. PMID: 34368899 Abstract Title:  Chloroform extract and acetyl-11-keto-beta-boswellic acid from Boswellia dalzielii stem bark induce apoptosis and cell cycle blockage in AW8507 cells. Abstract:  BACKGROUND: Globally, head and neck cancer is the sixth most common cancer. Despite the advancement in treatment, drug resistance remains a major cause for setback. In an earlier work, the authors reported that Boswellia dalzielii (Hutch) stem bark exhibited dose-dependent cytotoxicity in head and neck cancer cells, AW8507. Therefore, the cell death induction effect of Boswellia dalzielii stem bark chloroform extract in head and neck cancer cell line, AW8507, and its derived constituent on cell cycle and apoptosis proteins was further investigated.METHODS: The cell death induction activity of the Boswellia dalzielii stem bark chloroform fraction (CLBD) in AW8507 was determined using Annexin V-FITC/PI staining in flow cytometry. High-performance liquid chromatography-mass spectrometry was employed for compounds analysis of the CLBD, and reverse virtual screening was used to identify the mechanism of action of the compound, acetyl-11-keto-beta-boswellic acid, that was elucidated in the Boswellia dalzielii chloroform fraction.RESULTS: The data obtained showed that Boswellia dalzielii stem bark Chloroform extract increased the percentage of cells presenting… Read more

    - greenmedinfo

    PMID:  Nutr Metab (Lond). 2021 Aug 11 ;18(1):77. Epub 2021 Aug 11. PMID: 34380504 Abstract Title:  Anti-inflammatory and -apoptotic effects of a long-term herbal extract treatment on DSS-induced colitis in mice fed with high AGEs-fat diet. Abstract:  BACKGROUND: Obesity is associated with many comorbidities including inflammatory bowel disease (IBD). We investigated prophylactic effects of an herbal extract (HE) on the DSS-induced colitis mice challenged with high AGEs-fat diet 60% (HFD).METHODS: Six-week-old C57BL/6 male mice were fed with either HFD (8 groups, 6 mice in each group), or normal diet (ND) (8 groups, 6 mice in each group). After 6 weeks, animals received HE (combination of turmeric, ginger, boswellia and cat's claw extract) for 7 weeks in three doses (high dose (0.6 mg/g); low dose (0.15 mg/g) and mid dose (0.3 mg/g)). Next, mice were subjected to 2.5% DSS in drinking water. Control mice received ND and instead of HE and DSS they received distilled water. Obesity index markers were determined, H&E staining and TUNEL assay evaluated apoptosis. Colonic expressions of IL-6, RAGE, AGER1, Sirt1, Bax, Bcl2, ZO-1 and P53 were determined.RESULTS: HE ameliorated colitis in HFD mice by reducing colonic myeloperoxidase activity (by 2.3-fold), macrophage accumulation (by 2.6-fold) and mRNA expression of IL-6 (by 2.3-fold)… Read more

    - greenmedinfo

    PMID:  Medicines (Basel). 2018 Aug 31 ;5(3). Epub 2018 Aug 31. PMID: 30200355 Abstract Title:  Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids fromOleo-Gum Resins. Abstract:  Frankincense, the oleo-gum resin oftrees, has been used in traditional medicine since ancient times. Frankincense has been used to treat wounds and skin infections, inflammatory diseases, dementia, and various other conditions. However, in many cases, the biomolecular targets for frankincense components are not well established.In this work, we have carried out a reverse docking study ofditerpenoids and triterpenoids with a library of 16034 potential druggable target proteins.diterpenoids showed selective docking to acetylcholinesterase, several bacterial target proteins, and HIV-1 reverse transcriptase.triterpenoids targeted the cancer-relevant proteins (poly(ADP-ribose) polymerase-1, tankyrase, and folate receptorβ), inflammation-relevant proteins (phospholipase A2, epoxide hydrolase, and fibroblast collagenase), and the diabetes target 11β-hydroxysteroid dehydrogenase.The preferential docking ofterpenoids is consistent with the traditional uses and the established biological activities of frankincense. read more Read more

    - greenmedinfo

    PMID:  Postepy Hig Med Dosw (Online). 2016 Jan 4 ;70:380-91. Epub 2016 Jan 4. PMID: 27117114 Abstract Title:  Frankincense--therapeutic properties. Abstract:  Recently, increasing interest in natural dietary and therapeutic preparations used as dietary supplements has been observed. One of them is frankincense. This traditional medicine of the East is believed to have anti-inflammatory, expectorant, antiseptic, and even anxiolytic and anti-neurotic effects. The present study aims to verify the reported therapeutic properties of Boswellia resin and describe its chemical composition based on available scientific studies. The main component of frankincense is oil (60%). It contains mono- (13%) and diterpenes (40%) as well as ethyl acetate (21.4%), octyl acetate (13.4%) and methylanisole (7.6%). The highest biological activity among terpenes is characteristic of 11-keto-ß-acetyl-beta-boswellic acid, acetyl-11-keto-ß-boswellic acid and acetyl-α-boswellic acid. Contemporary studies have shown that resin indeed has an analgesic, tranquilising and anti-bacterial effects. From the point of view of therapeutic properties, extracts from Boswellia serrata and Boswelliacarterii are reported to be particularly useful. They reduce inflammatory conditions in the course of rheumatism by inhibiting leukocyte elastase and degrading glycosaminoglycans. Boswellia preparations inhibit 5-lipoxygenase and prevent the release of leukotrienes, thus having an anti-inflammatoryeffect in ulcerative colitis, irritable bowel syndrome, bronchitis and sinusitis.… Read more

    - greenmedinfo

    PMID:  Phytochemistry. 2021 Nov ;191:112897. Epub 2021 Aug 17. PMID: 34412004 Abstract Title:  Cembranoids from Boswellia species. Abstract:  Frankincense of Boswellia species has long been used in traditional medicines, mainly for its interesting anti-inflammatory and anti-depressant properties of its di- and triterpenes. Boswellic acids (triterpenes) and cembranoids (diterpenes) are the major constituents of frankincense from all reported species which are responsible for the overall biological activity of frankincense. Boswellic acids have been thoroughly investigated for decades but cembranoids have attracted considerable attention only recently, and a good number of publications have highlighted the important role of these 14-membered rings in contributing to the superior anti-inflammatory activity of the sacred resin. Partial and total syntheses of some cembranoids from frankincense have been reported. Their therapeutic potential is not limited to the well proven anti-inflammatory activity but also to their recently reported anti-depressant properties. There is a considerable number of publications in the field of cembranoids of Boswellia species where we feel a review in this topic will be of interest to the readership of Phytochemistry. In this article we have discussed the chemistry (isolation and chemical structures as well as synthetic studies), biogenesis and bioactivity of the reported cembranoids of Boswellia… Read more

    - greenmedinfo

    PMID:  Naunyn Schmiedebergs Arch Pharmacol. 2021 Nov ;394(11):2167-2185. Epub 2021 Sep 20. PMID: 34542667 Abstract Title:  Potential therapeutic effects of boswellic acids/Boswellia serrata extract in the prevention and therapy of type 2 diabetes and Alzheimer's disease. Abstract:  The link between diabetes and cognitive dysfunction has been reported in many recent articles. There is currently no disease-modifying treatment available for cognitive impairment. Boswellia serrata (B. serrata) is used traditionally to treat chronic inflammatory diseases such as type 2 diabetes (T2D), insulin resistance (IR), and Alzheimer's disease (AD). This review aims to highlight current research on the potential use of boswellic acids (BAs)/B. serrata extract in T2D and AD. We reviewed the published information through June 2021. Studies have been collected through a search on online electronic databases (Academic libraries as PubMed, Scopus, Web of Science, and Egyptian Knowledge Bank). Accumulating evidence in preclinical and small human clinical studies has indicated that BAs/B. serrata extract has potential therapeutic effect in T2D and AD. According to most of the authors, the potential therapeutic effects of BAs/B. serrata extract in T2D and AD can be attributed to immunomodulatory, anti-inflammatory, antioxidant activity, and elimination of the senescent cells. BAs/B. serrata extract may act by inhibiting… Read more

    - greenmedinfo

    PMID:  Chin J Nat Med. 2021 Sep ;19(9):686-692. PMID: 34561080 Abstract Title:  New tirucallane-type triterpenoids from the resin of Boswellia carteriiand their NO inhibitory activities. Abstract:  Six new tirucallane-type triterpenoids (1-6), along with ten known triterpenoids, were isolated from methylene chloride extract of the resin of Boswellia carterii Birdw. By the application of the comprehensive spectroscopic data, the structures of the compounds were clarified. The experimental electronic circular dichroism spectra were compared with those calculated, which allowed to assign the absolute configurations. Compounds 5 and 6 possesed a 2, 3-seco tirucallane-type triterpenoid skeleton, which were first reported. Their inhibitory activity against NO formation in LPS-activated BV-2 cells were evaluated. Compound 9 showed appreciable inhibitory effect, with an ICvalue of 7.58± 0.87 μmol·L. read more Read more

    - greenmedinfo

    PMID:  Biomed Pharmacother. 2021 Oct 1 ;144:112250. Epub 2021 Oct 1. PMID: 34607104 Abstract Title:  Mechanistic role of boswellic acids in Alzheimer's disease: Emphasis on anti-inflammatory properties. Abstract:  The resin/gum of Boswellia species belonging to the family of Burseraceae is a naturally occurring mixture of bioactive compounds, which was traditionally used as a folk medicine to treat conditions like chronic inflammation. Several research studies have also explored its' therapeutic potential against multiple neurodegenerative diseases such as Alzheimer's disease (AD). The main chemical constituents of this gum include boswellic acids (BAs) like 3-O-acetyl-11-keto-β boswellic acid (AKBA) that possess potent anti-inflammatory and neuroprotective properties in AD. It is also involved in inhibiting the acetylcholinesterase (AChE) activity in the cholinergic pathway and improve choline levels as well as its binding with nicotinic receptors to produce anti-inflammatory effects. Multiple shreds of evidence have demonstrated that BAs modulate key molecular targets and signalling pathways like 5-lipoxygenase/cyclooxygenase, Nrf2, NF-kB, cholinergic, amyloid-beta (Aβ), and neurofibrillary tangles formation (NFTs) that are involved in AD progression. The present review focuses on the possible mechanistic therapeutic role of BAs in modulating the 5-LOX/COX pathway in arachidonic acid metabolism, activating Nrf2 through binding of ARE, inhibiting NF-kB and AChE activity. In… Read more

    - GMI reporter

    What made the FDA so eager to approve the emergency permit for children? Why is this approval given based on a safety report that is not even "cooked" half way? Read more

    - GMI reporter
    'Serious Violations and Manipulations of Trial Protocol': How Pfizer Obtained FDA Emergency Authorization for Children

    Originally published on www.americasfrontlinedoctors.org by Dr. Yaffa Shir-Razread more Read more

    - greenmedinfo

    PMID:  J Ethnopharmacol. 2021 Apr 24 ;270:113793. Epub 2021 Jan 7. PMID: 33421599 Abstract Title:  Protective effects of myrrh essential oil on isoproterenol-induced myocardial infarction in rats through antioxidant, anti-inflammatory, Nrf2/HO-1 and apoptotic pathways. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Myrrh, a traditional remedy, is the stem resinous exudate of Commiphora molmol Engler (Burseraceae). The aromatic yellowish-brown oleoresin has a long history in folk and traditional medicine, in Saudi Arabia and the Arab world. Severe universal concern attributable to the high mortality is Myocardial Infarction (MI). Acute administration of Isoproterenol (ISO) is an established animal model to induce myocardial injury.OBJECTIVE: The existing animal study was outlined to inspect the actions of Myrrh essential oil on cardiac functional, antioxidant status, apoptotic and inflammatory deviations in isoproterenol induced MI.MATERIALS AND METHODS: Normal and Myrrh control animals were administered normal saline and Myrrh essential oil for thirty days orally, respectively. On the 29th and 30th day, the animals were injected by saline (s.c.). In the ISO control, the animals were administered saline orally for 30 days and then confronted with ISO (85 mg/kg s.c.) on 29th and 30th days. In the Myrrh Groups (IV and V), the animals were treated with Myrrh essential oil (50 and 100… Read more

    - greenmedinfo

    PMID:  Saudi Dent J. 2021 Jan ;33(1):44-54. Epub 2019 Dec 16. PMID: 33473242 Abstract Title:  Efficacy ofmyrrh mouthwash on early wound healing after tooth extraction: A randomized controlled trial. Abstract:  Background: The early period after tooth extraction is a critical period for wound healing. Wound healing after tooth extraction is considered secondary intention healing. It passes through several stages in the following order: hemostasis, inflammatory phase, proliferative phase, and finally the remodeling phase.Wounds usually heal normally unless there is interference by local or systemic factors. In certain circumstances, early wound healing can be enhanced by several interventions such as antibiotics, mouthwashes, or topical medications. Myrrh has been used as a topical medication for promoting wound healing after tooth extraction. The purpose of this study was to assess the wound healing effect of myrrh mouthwash during the early post-extraction period.Methods: We enrolled 40 healthy adult patients in this study (20: study group and 20: control group). All the activities performed for each group were double-blinded. All the participants underwent dental extraction under local anesthesia using standard protocol. Next, the study group used(myrrh) extract as a mouthwash while the control group used normal saline mouthwash. The participants used the mouthwashes twice a… Read more

    - greenmedinfo

    PMID:  Int Immunopharmacol. 2020 Dec ;89(Pt B):107094. Epub 2020 Oct 28. PMID: 33129097 Abstract Title:  Z-Guggulsterone alleviated oxidative stress and inflammation through inhibiting the TXNIP/NLRP3 axis in ischemic stroke. Abstract:  Ischemic stroke is a serious and life-threatening cerebrovascular thrombotic disease; however, the therapeutic strategy is limited for the complicated mechanism and narrow therapeutic window. Our previous study suggested that Z-Guggulsterone (Z-GS), an active component derived from myrrh, is a good candidate for cerebral injury. The object of this study is to investigate the exact mechanisms of Z-GS in cerebral ischemic stroke. Rats were used to conduct middle cerebral artery occlusion (MCAO) model and were treated with different dosage of Z-GS. Morphological results showed that Z-GS significantly alleviated neurological deficits, infarct volume and histopathological damage in MCAO rats. A total of 8276 differentially expressed genes were identified based on microarray analysis. Oxidation-reduction process and inflammatory response were enriched as the significant gene ontology items. TXNIP and NLRP3 were screened as the potential target genes by Series Test of Cluster (STC) analysis. The results were validated by immunohistochemistry and immunofluorescence staining. Besides, Z-GS successfully inhibited oxidative stress and inflammatory response in oxygen-glucose deprivation (OGD) treated neurons. Knockdown of TXNIP significantly decreased the… Read more

    - greenmedinfo

    PMID:  Int Immunopharmacol. 2021 Apr ;93:107395. Epub 2021 Jan 30. PMID: 33529916 Abstract Title:  Z-guggulsterone induces PD-L1 upregulation partly mediated by FXR, Akt and Erk1/2 signaling pathways in non-small cell lung cancer. Abstract:  Programmed death-ligand 1 (PD-L1) is an immune checkpoint molecule, that is overexpressed in non-small cell lung cancer (NSCLC) and has been associated with the response to anti-PD-1/PD-L1 immunotherapy. Z-guggulsterone (Z-GS), an active compound extracted from the gumresin of the Commiphora mukul tree, has been shown to have anti-tumor effects in NSCLC in our previous study. However, whether Z-GS could affect PD-L1 expression levels in tumor cells remains unknown. In this study, we verified the inhibitory effects of Z-GS on NSCLC cell viability and cell cycle progression in vitro, and mouse Lewis lung carcinoma (LLC) tumor growth in vivo. Notably, Z-GS treatment increased PD-L1 surface and mRNA expression levels, and gene transcription in NSCLC cells, in a dose- and time-dependent manner. Mechanistic experiments showed that the upregulation of PD-L1 was mediated, partly by farnesoid X receptor inhibition, and partly by the activation of the Akt and Erk1/2 signaling pathways in Z-GS-treated NSCLC cells. In vivo, Z-GS treatment dose-dependently increased PD-L1 expression levels in mouse LLC tumor models. Overall, our findings… Read more

    - greenmedinfo

    PMID:  ScientificWorldJournal. 2021 ;2021:3152304. Epub 2021 Jan 4. PMID: 33488300 Abstract Title:  Z-Guggulsterone Induces Apoptosis in Gastric Cancer Cells through the Intrinsic Mitochondria-Dependent Pathway. Abstract:  Background: To study the effects of z-guggulsterone on gastric cancer cell apoptosis and the mechanism related.Materials and Methods: Human gastric tumor SGC-7901 cells and GES-1 normal epithelial cells were treated with z-guggulsterone (0-75 M) for 24 h. MTT assay was applied to evaluate cell proliferation. Flow cytometry and Hoechst staining were used to assess cell apoptosis. Western blotting was applied to evaluate FXR, small heterodimer partner (SHP), Bcl-2, and Bax protein expression. ELISA was applied to gain the levels of active caspase-3 and the contents of TNF-, TGF-1, and VEGF.Results: The expression levels of FXR and SHP were higher in tumor cells than in normal epithelial cells. Inhibition of FXR signaling with z-guggulsterone dose-dependently inhibited SGC-7901 cell proliferation and promoted SGC-7901 cell apoptosis. Bcl-2 protein expression was significantly decreased, and active caspase-3 and Bax protein expression was increased in SGC-7901 cells incubated with z-guggulsterone. The content of TNF-was significantly increased, and the contents of VEGF and TGF-1 were decreased in SGC-7901 cells incubated with z-guggulsterone.Conclusions: Inhibition of FXR signaling with z-guggulsterone induced anticancer effects in SGC-7901 cells… Read more

    - greenmedinfo

    PMID:  Obes Med. 2021 Jun ;24:100346. Epub 2021 Apr 29. PMID: 33942025 Abstract Title:  Therapeutic use of Guggulsterone in COVID-19 induced obesity (COVIBESITY) and significant role in immunomodulatory effect. Abstract:  COVID-19 has emerged as a major cause of health crisis around the world. Psychosocial, Behavioral and metabolic changes especially weight gain, among variety of population was produced in this pandemic, through variety of mechanisms. Hyperlipidemia is one of the major issues that result in serious cardiovascular complications. Governmental strategies to minimize the spread of COVID-19 through closures, lockdowns, and alterations in social interaction have complicated weight management efforts. And immunity being the need of the hour has to be improved to prevent the infection. Guggulsterone (GS) isomers are major bioactive compounds present inandGuggulsterone shows anti-hyperlipidemic, anti-oxidant, anti-inflammatory, immunomodulatory and appetite regulating activity due to its peculiar characteristics. On the basis of clinical evidence, Guggulsterone seems to possess good cholesterol lowering, appetite regulating as well as immunomodulatory activity which can be beneficial during the pandemic of COVID-19. read more Read more

    - greenmedinfo

    PMID:  Phytomedicine. 2021 Jul ;87:153587. Epub 2021 May 5. PMID: 34044254 Abstract Title:  Guggulsterone induces apoptosis and inhibits lysosomal-dependent migration in human bladder cancer cells. Abstract:  BACKGROUND: The survival rate and therapeutic options for patients with bladder cancer have improved little in recent decades. Guggulsterone (GS), a phytoestrogen, has been investigated as an anticancer drug in various malignancies.PURPOSE: The present study aimed to evaluate the anticancer effects of E-isomer and Z-isomer GS in the human bladder cancer cell lines TSGH8301 (low-grade) and T24 (high-grade) and their underlying mechanisms.METHODS: The cell survival effect of GS was investigated by the MTT and colony formation assays in bladder cancer cell lines. Flow cytometry was used to analyze the cell cycle and cell death. Migration ability was measured by wound healing and transwell assays. Protein expression was determined by Western blot after GS treatment. The potency of GS on subcutaneous TSGH8301 bladder tumors was evaluated using an in vivo imaging system.RESULTS: E-isomer GS reduced the survival rate of both low- and high-grade human bladder cancer cells. GS caused cell cycle arrest, accompanied by the decrease and increase in cyclin A and p21 levels, respectively. Additionally, caspase-dependent apoptosis was observed following GS treatment. Furthermore, GS… Read more

    Researchers found that complex teeth, a hallmark of mammals, also evolved several times in reptiles, prompting the evolutionary success of plant-eating lizards. However, contrary to mammals their tooth evolution was not unidirectional. Read more

    In the early solar system, a 'protoplanetary disk' of dust and gas rotated around the sun and eventually coalesced into the planets we know today. A new study suggests that a mysterious gap existed within this disk around 4.567 billion years ago, and likely shaped the composition of the solar system's infant planets. Read more

    Ocean warming caused by anthropogenic greenhouse gas emissions will prompt many species of marine plankton to seek out new habitats, in some cases as a matter of survival. Researchers expect many organisms to head to the poles and form new communities -- with unforeseeable consequences for marine food webs. Read more

    A new data-driven system accelerates the process of discovering 3D printing materials that have multiple mechanical properties. Read more

    Magnetic solids can be demagnetized quickly with a short laser pulse, and there are already so-called HAMR (Heat Assisted Magnetic Recording) memories on the market that function according to this principle. However, the microscopic mechanisms of ultrafast demagnetization remain unclear. Now, a team has developed a new method at BESSY II to quantify one of these mechanisms and applied it to the rare-earth element Gadolinium, whose magnetic properties are caused by electrons on both the 4f and the 5d shells. Read more

    A study involving some 11,000 dogs demonstrated that the gender, age and breed of the dog, as well as any behavioral problems and certain environmental factors, are connected to hyperactive and impulsive behavior and inattention (ADHD). Read more

    Patients who have cardiovascular disease are at increased risk of serious complications from the flu, according to a new study. The study found that not only are traditional flu-related outcomes worse among some patients with CVD, but infection in those patients also is associated with an increased risk of cardiovascular events. Getting the influenza vaccine, however, substantially reduces cardiovascular risks. Read more

    When the brain stores memories of objects, it creates a characteristic pattern of activity for each of them. Stress changes such memory traces. Read more

    Bacteria can store extra resources for the lean times. It's a bit like keeping a piggy bank or carrying a backup battery pack. One important reserve is known as cyanophycin granules, which were first noticed by an Italian scientist about 150 years ago. He saw big, dark splotches in the cells of the blue-green algae (cyanobacteria) he was studying without understanding either what they were or their purpose. Since then, scientists have realized that cyanophycin was made of a natural green biopolymer, that bacteria use it as a store of nitrogen and energy, and that it could have many biotechnological applications. Read more

    Researchers have identified a protein that plays a key role in how the brain regulates appetite and metabolism. Loss of the protein, XRN1, from the forebrain, resulted in obese mice with an insatiable appetite, according to a new study. Read more

    Between 2016 and 2018, researchers studied wild boar and rat snakes across a range of radiation exposures in Fukushima. The team examined biomarkers of DNA damage and stress and did not find any significant adverse health effects. Read more

    An important cellular structure called the nuclear pore complex (NPC) has larger dimensions than previously thought. A research team made this discovery using cryo-focused ion beam (cryo-FIB) milling and cryo-electron tomography (cryo-ET) -- which allowed them to analyze the NPC directly inside cells. Read more

    A discovery of how to build little blocks out of DNA and get them to stick to lipids has implications for biosensing and mRNA vaccines. Read more

    The immune cells, known as microglia, also help regulate blood flow and maintain the brain's critical blood vessels, researchers have discovered. The findings may prove important in cognitive decline, dementia and stroke, among other conditions linked to diseases of the brain's small vessels. Read more

    A study has revealed for the first time that the contraceptive pill can reduce the risk of type 2 diabetes by over a quarter in women with polycystic ovary syndrome (PCOS). The research findings also show that women with PCOS have twice the risk of developing type 2 diabetes or pre-diabetes (dysglycemia) -- highlighting the urgent need to find treatments to reduce this risk. Read more

    Scientists have developed a smart pulse-shaper integrated on a chip. Read more

    Four weeks on a diet of highly processed food led to a strong inflammatory response in the brains of aging rats that was accompanied by behavioral signs of memory loss, a new study has found. Researchers also found that supplementing the processed diet with the omega-3 fatty acid DHA prevented memory problems and reduced the inflammatory effects almost entirely in older rats. Read more

    In the fight against multidrug-resistant bacteria, scientists have developed a new kind of antibiotic-free protection for wounds that kills drug-resistant bacteria and induces the body's own immune responses to fight infections. Read more

    Replacing petroleum-based aviation fuel with sustainable aviation fuel derived from a type of mustard plant can reduce carbon emissions by up to 68%, according to new research. Read more

    Researchers may have an uncovered new answers on how to create safer opioids. Design a new opioid to bypass the part of brain that feels pleasure, but retain the analgesic properties, which make opioids one of the most effective pain relievers. Researchers looked at how opioids may have become so widely abused. Read more

    Noninvasive glucose monitoring devices are not currently commercially available in the United States, so people with diabetes must collect blood samples or use sensors embedded under the skin to measure their blood sugar levels. Now, with a new wearable device less intrusive glucose monitoring could become the norm. Read more

    Stem-like cells that make up only a tiny fraction of the total cells in a lung tumor could be the key to stopping the disease's deadly spread, say researchers. Read more

    One potential cost-effective way to sustain ageing concrete subjected to harsh environmental conditions is to externally coat the material with fiber reinforced polymer composites. But few studies have looked at the durability of such strengthening. Now, researchers from Korea and the USA conduct a 13-year long experiment to find out. Read more

    A new article presents a new methodology to create a watershed-scale flood model based on LiDAR data. Read more

    Scientists have explored different approaches to catalysis, a chemical process that plays an essential role in biological reactions, as well as many industrial applications. Chemical catalysts have been used in a variety of human applications, ranging from pharmaceutical development to biodegradable plastics and environmentally safe fertilizers. They may also advance the development of green energy solutions to address the climate crisis. Read more

    Researchers have discovered how neurons in a small area of the mammalian brain help filter distracting or disruptive signals -- specifically from the hands -- to coordinate dexterous movements. Their results may hold lessons in how the brain filters other sensory information as well. Read more

    A new study has found that genes can explain up to 72% of the difference in outcome between people after a specific fitness exercise. The research involved data from 3,012 adults and has identified a number of specific genes which influence the outcomes of different physical activities. Read more

    A compositional link between planets and their respective host star has long been assumed in astronomy. Scientists now deliver empirical evidence to support the assumption -- and partly contradict it at the same time. Read more

    Researchers developed a metasurface that uses very deep, very narrow holes, rather than very tall pillars, to focus light to a single spot. Read more

    Air pollution is known to harm children's respiratory health, but its specific impacts on infection rates have remained unclear. A new analysis provides evidence of a link between the two in low-income settings, and indicates one industry may play an outsized role in the problem. Read more

    Researchers have discovered two alarming trends in Takotsubo cardiomyopathy -- also known as 'broken heart' syndrome -- a condition that is often triggered by stress or loss and can lead to long-term heart injury and impaired heart function. Read more

    Hot desert sex has resulted in major genetic differences between male and female jojoba plants -- one of only 6 percent of plants that require a male and female plant to reproduce. New research suggests male and female jojoba plants have diverged so much, that the jojoba plant has more novel sex genes than any other known living organism. The discovery may help researchers develop a DNA test to identify male and female jojoba plants, which cannot be distinguished from each other as seedlings - and shed light on how plants adapt to environmental stress. Read more

    Lizards can regrow severed tails, making them the closest relative to humans that can regenerate a lost appendage. But in lieu of the original tail that includes a spinal column and nerves, the replacement structure is an imperfect cartilage tube. Now, a study describes how stem cells can help lizards regenerate better tails. Read more

    Although there has been evidence of our species living in rainforest regions in Southeast Asia from at least 70,000 years ago, the poor preservation of organic material in these regions limits how much we know about their diet and ecological adaptations to these habitats. An international team of scientists has now applied a new method to investigate the diet of fossil humans: the analysis of stable zinc isotopes from tooth enamel. This method proves particularly helpful to learn whether prehistoric humans and animals were primarily eating meat or plants. Read more

    The production of renewable energy is increasing every year. But after analyzing the growth rates of wind and solar power in 60 countries, researchers conclude that virtually no country is moving sufficiently fast to avoid global warming of 1.5°C or even 2°C. The article "National growth dynamics of wind and solar power compared to the growth required for global climate targets" was published in the journal Nature Energy, written by Aleh Cherp, Vadim Vinichenko, Jale Tosun, Joel A.Gordon and Jessica Jewell. Read more

    Scientists have developed a fully operational standalone solar-powered mini-reactor which offers the potential for the production of fine chemicals in remote locations on Earth, and possibly even on Mars. Read more

    A new study used functional magnetic resonance imaging to examine the brain activity of 51 male-female romantic couples as they experienced intimate partner aggression in real time. They found that aggression toward intimate partners was associated with aberrant activity in the brain's medial prefrontal cortex, or MPFC, which has many functions, but among them is the ability to foster perceptions of closeness with and value of other people. Read more

    Researchers have developed a new technique to improve understanding of how acid damages teeth at the microstructural level. Read more

    Modern snakes evolved from ancestors that lived side by side with the dinosaurs and that likely fed mainly on insects and lizards. Read more

    Researchers have discovered how T cells -- an important component of our immune system -- are able keep on killing as they hunt down and kill cancer cells, repeatedly reloading their toxic weapons. Read more

Join Our Newsletter

Join our mailing list to receive the latest news and updates from our team.

Please enter a valid email address.
Something went wrong. Please check your entries and try again.