Healers & Therapists News

Healers & Therapists News from June Meagher of AAMARHealing brings you the latest news from sources such as the BBC Health pages as well as the Green Med Info pages and Science Daily, we will be adding more news feeds shortly. Join the conversations on our LinkedIn group which has over 18,000 healers and therapists from around the globe and discover even more news and tips. If you have any news you would like to add to our website, please contact me and I can add it to our blog.

 

    • BBC News - Health
    • GreenMedInfo
    • Latest Science News -- ScienceDaily

    Infection rates are declining overall, but some regions are seeing a rise in cases. Read more

    Over-40s will be first in line from mid-April after the top nine priority groups receive one dose. Read more

    There was a 75% reduction in staff at Addenbrooke's Hospital testing positive after a vaccination. Read more

    The monarch, who had her first dose of the vaccine in January, said it "didn't hurt at all". Read more

    A bill to give ministers maternity pay will change, after peers reject the use of the term "person". Read more

    Symptoms left unchecked included lumps, changes to moles and coughing up blood, a survey finds. Read more

    The boss of outsourcer Serco says there are now as many people being tested per week as vaccinated. Read more

    It comes after DJ Jo Whiley's call for people like her sister to be vaccinated as soon as possible. Read more

    US regulators say Johnson and Johnson's single-shot vaccine is safe, and could be approved in days. Read more

    About 31,000 women will be offered the swab checks, which can help spot early signs of cervical cancer. Read more

    The vaccine-sharing scheme aims to help poorer countries like Ghana get Covid-19 jabs. Read more

    But it is too soon to say when social distancing rules will be relaxed, the health secretary says. Read more

    The high cost of fertility treatment leads some to find donors on social media, even though it's risky and could be illegal. Read more

    Some women who've had the condition have been told to shield while others have not. Read more

    Since the first case in northern Italy a year ago the lives of Europeans have been changed forever. Read more

    Dr John Wright says he's often asked which vaccine is best, but the answer is it's too early to say. Read more

    Jordan Charles went months with undiagnosed diabetes after contracting Covid-19. Read more

    Some volunteers in the UK will be deliberately infected with coronavirus in a "challenge trial". Read more

    Deaths are falling faster for the over-80s - but does that mean the vaccine is working? Read more

    Coronavirus has had a big impact on our mental health, but have services been able to keep up? Read more

    More people have been added to the clinically extremely vulnerable list in England. Why? Read more

    As the UK cautiously unlocks, experts will review the evidence on when and where masks are needed. Read more

    Two approved Covid vaccines are being rolled out across the UK. So when might you get one? Read more

    Why experts are concerned about the emergence of this particular new version of coronavirus. Read more

    The prime minister has announced a plan for how the lockdown will be lifted in England. Read more

    Explore the data on coronavirus in the UK and find out how many cases there are in your area. Read more

    What is it like to have the coronavirus, how will it affect you and how is it treated? Read more

    Some people across the UK have been able to form "support bubbles" or "extended households". Read more

    What are the tests for coronavirus, who are they for, and how do they work? Read more

    A new cough, fever and change in smell or taste are the key symptoms that mean you may have coronavirus. Read more

    Use our tool to check the meaning of key words and phrases associated with the Covid-19 outbreak. Read more

    While most people will have mild symptoms and recover quickly, some are more prone to getting sick. Read more

    With face masks in high demand, we look at whether they really can protect people from the virus. Read more

    After phase one is complete by mid-April, in what order will all other adults get the jab? Read more

    A nurse who died with Covid-19 inspired nearly her entire family to join the NHS. Read more

    Nearly 200,000 extremely clinically vulnerable young people have been offered their vaccine. Read more

    The body which advises the government on Coronavirus vaccines says everyone registered as having a learning disability is now eligible for a jab. Read more

    A global scheme aims to ensure people in poorer countries get vaccinated against Covid. Read more

    - greenmedinfo

    PMID:  Physiol Int. 2018 Jun 1 ;105(2):116-126. PMID: 29975123 Abstract Title:  Impact of loganin on pro-inflammatory cytokines and depression- and anxiety-like behaviors in male diabetic rats. Abstract:  Behavioral disturbances are observed in most patients suffering from diabetes. According to some evidence, pro-inflammatory cytokines have a key role both in diabetes and behavioral disorders, such as anxiety and depression. In this study, the effect of chronic administration of loganin, as a bioflavonoid, was investigated on pro-inflammatory cytokines and depression- and anxiety-like behaviors in streptozotocin-induced diabetes in male Wistar rats. Blood levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were assessed by enzyme-linked immunosorbent assay method. Depression- and anxiety-like behaviors were evaluated by forced swimming test (FST), elevated plus maze (EPM), and open field test (OFT), respectively. Body weight was also measured before the interventions and after the experiments in all groups. Our findings show that loganin-treated animals had significantly lower serum concentrations of IL-6 and TNF-α compared with the diabetic group. In the EPM test, loganin treatment significantly increased the percentage of the open arm time and open arm entries. Moreover, loganin treatmentsignificantly decreased the grooming time and restored distance traveled and center crossing in the OFT. However, it decreased… Read more

    - GiorgioAgamben
    Biosecurity and Politics (Giorgio Agamben)

    This article is copyrighted by GreenMedInfo LLC, 2021Visit our Re-post guidelinesread more Read more

    - greenmedinfo

    PMID:  Cell Biol Int. 2018 Dec ;42(12):1632-1642. Epub 2018 Oct 31. PMID: 30288860 Abstract Title:  Loganin prevents BV-2 microglia cells from Aβ-induced inflammation via regulating TLR4/TRAF6/NF-κB axis. Abstract:  Neuroinflammation is closely related with the pathogenesis and progress of neurodegenerative diseases including Alzheimer's disease (AD). Loganin, an iridoid glycoside obtained from traditional Chinese medicine Cornus officinalis, has properties of inhibiting inflammation and improving memory. The present study was aimed to investigate effects of loganin on Aβ-induced inflammation and to explore the underlying mechanisms. BV-2 microglia cells were stimulated with 10 µM Aβfor 24 h to induce inflammatory damage. According to results of CCK-8 assay, the doses of loganin in present work were 10 and 30 µM. We found that treatment with loganin could inhibit Aβ-induced microglia activation. Furthermore, loganin treatment prevented the over-production of Tumor necrosis factor-α (TNF-α), Interleukin-6 (IL-6), Macrophage Chemotactic Protein 1(MCP-1), Nitric oxide (NO), Prostaglandin E2 (PGE2) and the up-regulation of inducible nitric oxide synthase (iNOS) and Cyclooxygenase 2 (COX-2) in Aβ-stimulated BV-2 cells. Results from Western blots demonstrated that loganin inhibited Aβ-induced elevation in Toll-like receptor 4 (TLR4), Myeloid Differentiation Factor 88 (MyD88) and TNF receptor-associated factor 6 (TRAF6). Loganin treatment also attenuated the increased phosphorylation level of IRAK4 caused… Read more

    - greenmedinfo

    PMID:  Front Pharmacol. 2019 ;10:409. Epub 2019 Apr 24. PMID: 31068813 Abstract Title:  Loganin Exerts Sedative and Hypnotic Effects via Modulation of the Serotonergic System and GABAergic Neurons. Abstract:  Corni fructus, the fruit ofSieb. et Zucc., has been used as a tonic for the kidney in China for thousands of years. Loganin is one of the major constituents derived from Corni fructus. In this study, we revealed the sedative and hypnotic activity of loganin and investigated its mechanisms for the first time. Pentobarbital-induced sleep test and insomnia mice models [induced by caffeine and p-chlorophenylalanine (PCPA)] were used for the assessment of sedative and hypnotic effects of loganin. It was found that loganin (20-50 mg/kg) exerted sedative effect in normal mice. Loganin exhibited hypnotic effect by increasing sleep onset and sleep duration in pentobarbital-treated mice, recovering PCPA-induced insomnia and exerting synergistic hypnosis effect with 5-HTP. In addition, electroencephalograph (EEG) and electromyography (EMG) recordings of rats showed that loganin (35 mg/kg) prolonged the ratio of non-rapid eye movement (NREM) sleep and shortened wakefulness significantly, further immunohistochemistry showed that loganin (35 mg/kg) increased c-Fos expression in GABAergic neurons of rats in the ventrolateral preoptic nucleus (VLPO). The levels of norepinephrine (NE), dopamine (DA),… Read more

    - greenmedinfo

    PMID:  Med Sci Monit. 2019 Jun 4 ;25:4159-4168. Epub 2019 Jun 4. PMID: 31162482 Abstract Title:  Loganin Attenuates Osteoarthritis in Rats by Inhibiting IL-1β-Induced Catabolism and Apoptosis in Chondrocytes Via Regulation of Phosphatidylinositol 3-Kinases (PI3K)/Akt. Abstract:  BACKGROUND Chondrocyte apoptosis and catabolism are 2 major factors that contribute to the progression of osteoarthritis (OA). Loganin, an iridoid glycoside present in several herbs, including Flos lonicerae, Cornus mas L, and Strychnos nux vomica, is a valuable medication with anti-inflammatory and anti-apoptotic effects. Our study examines these effects and explores the potential benefits of loganin in the OA treatment. MATERIAL AND METHODS To clarify the roles of loganin in OA and its specific signaling pathway, chondrocytes were administrated with IL-1ß and supplemented with or without LY294002 (a classic PI3K/Akt inhibitor). The apoptotic level, catabolic factors (MMP-3 and MMP-13 and ADAMTS-4 and ADAMTS-5), extracellular matrix (ECM) degradation, and activation of the PI3K/Akt pathway were evaluated using western blotting, PCR, and an immunofluorescent assay. The degenerative condition of the cartilage was evaluated using the Safranin O assay in vivo. The expression of cleaved-caspase-3 (C-caspase-3) was measured using immunochemistry. RESULTS The data suggested that loganin suppressed the apoptotic level, reduced the release of catabolic enzymes, and… Read more

    - greenmedinfo

    PMID:  J Ethnopharmacol. 2020 Jan 30 ;247:112261. Epub 2019 Sep 29. PMID: 31577939 Abstract Title:  Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Corni Fructus (CF), the red fruit of Cornus officinalis Siebold&Zucc, has been used both as food and medicinal herb in traditional Chinese medicine (TCM). Loganin is a major iridoid glycoside and one of the quality control indexes of CF. In TCM clinical practice, prescription containing CF is commonly used to treat osteoarthritis (OA), but the underlying mechanisms of loganin are not yet utterly understood.AIM OF THE STUDY: The aims of the present study are to confirm the therapeutic effects of loganin in an OA mouse model and to determine the mechanisms involved in the OA protective effects.MATERIALS AND METHODS: The destabilization of the medial meniscus (DMM) procedure was performed on the right knee of 8-week-old C57BL/6 male mice. 30 or 100 μg/ml of loganin was then injected into articular space twice a week for 8 and 12-week. Safranin O/Fast green staining, H&E staining, micro-CT analysis were performed to analyze structural and morphological changes. The protein expression of collagen type II (Col2), metalloproteinase-3… Read more

    - greenmedinfo

    PMID:  Kaohsiung J Med Sci. 2020 Apr ;36(4):257-264. Epub 2019 Dec 20. PMID: 31859422 Abstract Title:  Loganin alleviates LPS-activated intestinal epithelial inflammation by regulating TLR4/NF-κB and JAK/STAT3 signaling pathways. Abstract:  Inflammatory bowel disease (IBD) is a chronic, recurrent gastrointestinal inflammation that affects millions of people around the world. Loganin, an iridoid glycoside, has shown the anti-inflammatory effects. However, the effect of loganin on IBD and its underlying molecular mechanism are not clear. The present study aimed to investigate whether loganin could alleviate IBD and its mechanisms. The intestinal epithelial Caco-2 cell line was treated with lipopolysaccharide (LPS) to establish an in vitro IBD model. MTT assay was used to detect cell viability. The expression and release level of inflammatory factors were determined by both real-time-PCR and ELISA. Western blotting was used to assess the NF-κB and JAK/STAT3 pathway-related protein levels. The results showed that loganin repressed the expression and release of IL-6, TNF-α, and IL-1β, and inhibited TLR4/NF-κB and JAK/STAT3 signaling pathways in a concentration-dependent manner. Overexpression of TLR4 could reverse the effect of loganin, leading to activation of NF-κB signaling and production of inflammatory factors. Meanwhile, IGF-1, a JAK/STAT3 signaling activator, could also reverse the anti-inflammation effect of loganin.… Read more

    - greenmedinfo

    PMID:  Phytomedicine. 2020 Feb ;67:153166. Epub 2019 Dec 30. PMID: 31955133 Abstract Title:  Loganin prevents chronic constriction injury-provoked neuropathic pain by reducing TNF-α/IL-1β-mediated NF-κB activation and Schwann cell demyelination. Abstract:  BACKGROUND: Peripheral nerve injury can produce chronic and ultimately neuropathic pain. The chronic constriction injury (CCI) model has provided a deeper understanding of nociception and chronic pain. Loganin is a well-known herbal medicine with glucose-lowering action and neuroprotective activity.PURPOSE: This study investigated the molecular mechanisms by which loganin reduced CCI-induced neuropathic pain.METHODS: Sprague-Dawley rats were randomly divided into four groups: sham, sham+loganin, CCI and CCI+loganin. Loganin (1 or 5 mg/kg/day) was injected intraperitoneally once daily for 14 days, starting the day after CCI. For behavioral testing, mechanical and thermal responses were assessed before surgery and on d1, d3, d7 and d14 after surgery. Sciatic nerves (SNs) were collected to measure proinflammatory cytokines. Proximal and distal SNs were collected separately for Western blotting and immunofluorescence studies.RESULTS: Thermal hyperalgesia and mechanical allodynia were reduced in the loganin-treated group as compared to the CCI group. Loganin (5 mg/kg/day) prevented CCI from inducing proinflammatory cytokines (TNF-α, IL-1β), inflammatory proteins (TNF-α, IL-1β, pNFκB, pIκB/IκB, iNOS) and receptor (TNFR1, IL-1R), adaptor protein (TRAF2) of TNF-α, and Schwann cell… Read more

    - greenmedinfo

    PMID:  J Cell Mol Med. 2020 06 ;24(11):6083-6095. Epub 2020 Apr 19. PMID: 32307890 Abstract Title:  Loganin alleviates testicular damage and germ cell apoptosis induced by AGEs upon diabetes mellitus by suppressing the RAGE/p38MAPK/NF-κB pathway. Abstract:  Diabetes mellitus (DM) damages male reproduction at multiple levels, such as endocrine secretion, spermatogenesis and penile erection. We herein investigated the protective effects and mechanism of loganin targeting the advanced glycation end products (AGEs)/receptor for AGEs (RAGE)/p38 mitogen-activated protein kinase (p38MAPK)/NF-κB signalling pathway. Loganin relieved the general DM symptoms and decreased the blood glucose level of KK-Ay DM mice. Haematoxylin-eosin staining demonstrated that loganin ameliorated testicular histology and function and enhanced the activities of testis-specific markers lactate dehydrogenase (LDH), acid phosphatase (ACP) and gamma-glutamyl transferase (γ-GT). Loganin also showed evident anti-oxidative stress, anti-apoptotic and anti-inflammatory effects on DM-induced reproductive damage by restoring glutathione (GSH) level and superoxide dismutase (SOD) activity, as well as reducing reactive oxygen species (ROS) level and Bax/Bcl-2 ratio in vivo and in vitro. Western blotting exhibited that loganin significantly inhibited the AGEs/RAGE/p38MAPK/NF-κB signalling pathway. Acridine orange and ethidium bromide staining (AOEB) and Western blotting showed that loganin in combination withinhibitors of RAGE, p38MAPK and NF-κB exerted stronger anti-apoptotic effects on… Read more

    - greenmedinfo

    PMID:  Cells. 2020 08 23 ;9(9). Epub 2020 Aug 23. PMID: 32842536 Abstract Title:  Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation. Abstract:  Diabetic peripheral neuropathy (DPN) is caused by hyperglycemia, which induces oxidative stress and inflammatory responses that damage nerve tissue. Excessive generation of reactive oxygen species (ROS) and NOD-like receptor protein 3 (NLRP3) inflammasome activation trigger the inflammation and pyroptosis in diabetes. Schwann cell dysfunction further promotes DPN progression. Loganin has been shown to have antioxidant and anti-inflammatory neuroprotective activities. This study evaluated the neuroprotective effect of loganin on high-glucose (25 mM)-induced rat Schwann cell line RSC96 injury, a recognized in vitro cell model of DPN. RSC96 cells were pretreated with loganin (0.1, 1, 10, 25, 50μM) before exposure to high glucose. Loganin's effects were examined by CCK-8 assay, ROS assay, cell death assay, immunofluorescence staining, quantitative RT-PCR and western blot. High-glucose-treated RSC96 cells sustained cell viability loss, ROS generation, NF-κB nuclear translocation, P2 × 7purinergic receptor and TXNIP (thioredoxin-interacting protein) expression, NLRP3 inflammasome (NLRP3, ASC, caspase-1) activation, IL-1β and IL-18 maturation and gasdermin D cleavage. Those effects were reduced by loganin pretreatment. In conclusion, we found that loganin's antioxidant effects… Read more

    - greenmedinfo

    PMID:  Bioengineered. 2020 12 ;11(1):628-639. PMID: 33034242 Abstract Title:  Loganin inhibits macrophage M1 polarization and modulates sirt1/NF-κB signaling pathway to attenuate ulcerative colitis. Abstract:  Loganin, a major bioactive iridoid glycoside derived from Cornus officinalis, exerts different beneficial biological properties. Recently, loganin has been reported to exhibit potential anti-inflammatory effects in the intestinal tissues, while the detailed mechanisms remain elusive. This study aimed to investigate whether loganin could inhibit the inflammatory response in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) and to explore possible molecular mechanisms involved in this process. Results showed that oral administration of loganin significantly decreased body weight loss, disease activity index, colon shortening, myeloperoxidase (MPO) activity and pathologic abnormalities in UC mice. Loganin obviously inhibited the mRNA and protein levels of IL-6, TNF-α and IL-1β in colon tissues from UC mice. Furthermore, loganin remarkably reduced macrophage M1 polarization in UC mice evidenced by reduced the number of F4/80 and iNOS dual-stained M1 macrophages, and the expression of M1 macrophage-related pro-inflammatory chemokines/cytokines including MCP-1,CXCL10 as well as COX-2. Further investigation showed that loganin upregulated the mRNA and protein levels of Sirt1, with the inhibition of NF-κB-p65 acetylation in colon tissues from UC mice. Moreover, Sirt1-specific inhibitor Ex527 administration… Read more

    - greenmedinfo

    PMID:  Life Sci. 2020 Nov 24:118808. Epub 2020 Nov 24. PMID: 33245967 Abstract Title:  Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy. Abstract:  BACKGROUND/AIMS: The theory of inflammation is one of the important theories in the pathogenesis of diabetic nephropathy (DN). We herein aimed to explore whether loganin affected macrophage infiltration and activation upon diabetic nephropathy (DN) by a spontaneous DN mice and a co-culture system of glomerular mesangial cells (GMCs) and macrophage cells (RAW264.7) which was induced by advanced glycation end products (AGEs).METHODS AND KEY FINDINGS: Loganin showed remarkable capacity on protecting renal from damage by mitigating diabetic symptoms, improving the histomorphology of the kidney, decreasing the expression of extracellular matrix such as FN, COL-IV and TGF-β, reversing the production of IL-12 and IL-10 and decreasing the number of infiltrating macrophages in the kidney. Moreover, loganin showed markedly effects by suppressing iNOS and CD16/32 expressions (M1 markers), increasing Arg-1 and CD206 expressions (M2 markers), which were the phenotypic transformation of macrophage. These effects may be attributed to the inhibition of the receptor for AGEs (RAGE) /monocyte chemotactic protein-1 (MCP-1)/CC chemokine receptor 2 (CCR2) signaling pathway, with significantly down-regulated expressions of RAGE, MCP-1 and… Read more

    - greenmedinfo

    PMID:  Int J Mol Sci. 2021 Jan 31 ;22(3). Epub 2021 Jan 31. PMID: 33572597 Abstract Title:  Loganin Attenuates the Severity of Acute Kidney Injury Induced by Cisplatin through the Inhibition of ERK Activation in Mice. Abstract:  Cisplatin is the most widely used chemotherapeutic agent. However, it often causes nephrotoxicity, which results in acute kidney injury (AKI). Therefore, we urgently need a drug that can reduce the nephrotoxicity induced by cisplatin. Loganin is a major iridoid glycoside isolated from Corni fructus that has been used as an anti-inflammatory agent in various pathological models. However, the renal protective activity of loganin remains unclear. In this study, to examine the protective effect of loganin on cisplatin-induced AKI, male C57BL/6 mice were orally administered with loganin (1, 10, and 20 mg/kg) 1 h before intraperitoneal injection of cisplatin (10 mg/kg) and sacrificed at three days after the injection. The administration of loganin inhibited the elevation of blood urea nitrogen (BUN) and creatinine (CREA) in serum, which are used as biomarkers of AKI. Moreover, histological kidney injury, proximal tubule damages, and renal cell death, such as apoptosis and ferroptosis, were reduced by loganin treatment. Also, pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, and tumor… Read more

    - greenmedinfo

    PMID:  Drug Des Devel Ther. 2021 ;15:501-513. Epub 2021 Feb 11. PMID: 33603340 Abstract Title:  Loganin Attenuates Septic Acute Renal Injury with the Participation of AKT and Nrf2/HO-1 Signaling Pathways. Abstract:  Purpose: Sepsis, a destructive inflammatory response syndrome, is the principal reason to induce death in the intensive care unit. Loganin has been proved to possess the property of anti-inflammation, antioxidant, neuroprotection, and sedation. The primary aim of this study was to evaluate whether Loganin could alleviate acute kidney injury (AKI) during sepsis and investigate the latent mechanisms.Methods: Septic AKI models were established by cecal ligation and puncture (CLP) surgery in mice and given Loganin (20, 40, 80 mg/kg) by gavage. Lipopolysaccharides (LPS)-stimulated human kidney proximal tubular (HK2) cells incubated in Loganin (5, 10, 20μ M) were used to explore the accurate mechanisms. Survival rate, renal function (creatinine and blood urea nitrogen), and renal pathological changes were detected in septic mice. Oxidative stress markers (SOD, GSH-Px, MDA, and SOD), mitochondrial membrane potential, mitochondrial calcium overload,and nuclear factor E2-related factor 2 (Nrf2)/heme-oxygenase 1 (HO-1) pathway activation in vivo and in vitro were determined by commercial kits and Western blot. Cell apoptosis, apoptotic-related protein (cleaved caspase-3, Bcl-2, and Bax) expression and protein… Read more

    - greenmedinfo

    PMID:  Pharmaceuticals (Basel). 2021 Feb 8 ;14(2). Epub 2021 Feb 8. PMID: 33567513 Abstract Title:  Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model. Abstract:  Arthritis is a common inflammatory disease that causes pain, stiffness, and joint swelling. Here, we investigated the ameliorative effects of loganin on arthritis in vitro and in vivo. A single bioactive compound was fractionated and isolated from(CO) extract to screen for anti-arthritic effects. A single component, loganin, was identified as a candidate. The CO extract and loganin inhibited the expression of factors associated with cartilage degradation, such as cyclooxygenase-2 (COX-2), matrix metalloproteinase 3 (MMP-3), and matrix metalloproteinase 13 (MMP-13), in interukin-1 beta (IL-1β)-induced chondrocyte inflammation. In addition, prostaglandin and collagenase levels were reduced following treatment of IL-1β-induced chondrocytes with loganin. In the destabilization of the medial meniscus (DMM)-induced mouse model, loganin administration attenuated cartilage degeneration by inhibiting COX-2, MMP-3, and MMP-13. Transverse micro-CT images revealed that loganin reduced DMM-induced osteophyte formation. These results indicate that loganin has protective effects in DMM-induced mice. read more Read more

    - greenmedinfo

    PMID:  J Ethnopharmacol. 2021 Apr 24 ;270:113734. Epub 2020 Dec 24. PMID: 33359857 Abstract Title:  Cornus officinalis var. koreana Kitam polyphenol extract decreases pro-inflammatory markers in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages by reducing Akt phosphorylation. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Cornus officinalis var. koreana Kitam (CO) is found predominantly in China but also in Korea and Japan and has been used in Eastern medicine for over 2000 years to treat several conditions including diabetes, cardiovascular disease and kidney disease. Chronic inflammation underlies the pathogenesis of these diseases. The mechanisms by which CO may exert its anti-inflammatory effects have not been well defined.AIM OF THE STUDY: We aimed to determine whether Cornus officinalis var. koreana Kitam extract (COE) attenuate the inflammatory response induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages, and to elucidate the mechanisms which contribute to these anti-inflammatory effects.MATERIALS AND METHODS: COE was prepared using ethanolic extraction, followed by solvent evaporation and freeze-drying. RAW 264.7 macrophages were treated with 0, 50, 100, 200 and 400 μg/ml of COE. After 2 h, cells were treated with 100 ng/ml of LPS for 6 h. Cells were then collected for whole cell protein expression analysis of signaling and inflammatory molecules via western blot.RESULTS: Pre-treatment with 100, 200 and… Read more

    - greenmedinfo

    PMID:  Int J Mol Sci. 2020 Dec 15 ;21(24). Epub 2020 Dec 15. PMID: 33334082 Abstract Title:  Anti-Proliferative Effects of Standardizedon Benign Prostatic Epithelial Cells via the PCNA/E2F1-Dependent Cell Cycle Pathway. Abstract:  , widely used in traditional Chinese medicine, exhibits pharmacological effects against erectile dysfunction and pollakisuria, which are pathological symptoms of benign prostatic hyperplasia (BPH). Although traditional usage and a study on BPH have been reported, to our knowledge, no study has investigated the exact molecular mechanism(s) underlying the anti-proliferative effects of standardizedon prostatic cells. We standardized30% ethanol extract (COFE) and demonstrated the therapeutic effects of COFE on human BPH epithelial cells and testosterone-induced BPH in rats. In vitro studies using BPH-1 cells demonstrated an upregulation of BPH-related and E2F Transcription Factor 1(E2F1)-dependent cell cycle markers, whereas treatment with COFE clearly inhibited the proliferation of BPH epithelial cells and reduced the overexpression of G1 and S checkpoint genes. Additionally, COFE administration alleviated the androgen-dependent prostatic enlargement in a testosterone-induced BPH animal model. COFE exerted these anti-BPH effects by the inhibition of anti-apoptotic markers, suppression of PCNA expression, and regulation of E2F1/pRB-dependent cell cycle markers in rats with BPH. These results suggest that COFE exerts anti-proliferative effect by regulating PCNA/E2F1-dependent… Read more

    - greenmedinfo

    PMID:  Semin Cancer Biol. 2021 Jan 9. Epub 2021 Jan 9. PMID: 33434642 Abstract Title:  Dietary isothiocyanates inhibit cancer progression by modulation of epigenome. Abstract:  Cell cycle, growth, survival and metabolism are tightly regulated together and failure in cellular regulation leads to carcinogenesis. Several signaling pathways like the PI3K, WNT, MAPK and NFKb pathway exhibit aberrations in cancer and help achieve hallmark capabilities. Clinical research and in vitro studies have highlighted the role of epigenetic alterations in cancer onset and development. Altered gene expression patterns enabled by changes in DNA methylation, histone modifications and RNA processing have proven roles in cancer hallmark acquisition. The reversible nature of epigenetic processes offers robust therapeutic targets. Dietary bioactive compounds offer a vast compendium of effective therapeutic moieties. Isothiocyanates (ITCs) sourced from cruciferous vegetables demonstrate anti-proliferative, pro-apoptotic, anti-inflammatory, anti-migratory and anti-angiogenic effect against several cancers. ITCs also modulate the redox environment, modulate signaling pathways including PI3K, MAPK, WNT, and NFkB. They also modulate the epigenetic machinery by regulating the expression and activity of DNA methyltransferases, histone modifiers and miRNA. This further enhances their transcriptional modulation of key cellular regulators. In this review, we comprehensively assess the impact of ITCs such as sulforaphane, phenethyl isothiocyanate,… Read more

    - greenmedinfo

    PMID:  Oncol Rep. 2021 Jan ;45(1):337-348. Epub 2020 Nov 19. PMID: 33416137 Abstract Title:  Phenethyl isothiocyanate reduces breast cancer stem cell-like properties by epigenetic reactivation of CDH1. Abstract:  Breast cancer is the most frequently diagnosed malignancy and leading cause of cancer-related deaths among women worldwide. Tumor recurrence, or metastasis, is caused by cancer stem cells and has a dismal prognosis for breast cancer patients. Thus, targeting breast cancer stem cells (BCSCs) for eradication is a potential method to improve clinical outcomes. Phenethyl isothiocyanate (PEITC) is a novel epigenetic regulator derived from cruciferous vegetables that has marked antitumor effects. However, the exact mechanism of these antitumor effects by PEITC is unknown. As breast cancer progresses, a tumor suppressor in the breast, cadherin 1 (CDH1), is silenced by hypermethylation of the promoter region, further promoting the stem cell-like properties of cancer. Herein, the ability of PEITC to reduce BCSC-like properties by epigenetic reactivation of CDH1 was investigated by multiple analyses such as MTT, colony formation and sphere formation assays, methylation-specific PCR, western blot analysis, Co-IP and qPCR. It was revealed that PEITC inhibited colony and mammosphere formation and decreased the expression of protein markers associated with BCSC-like properties via epigenetic reactivation of CDH1. Further exploration of… Read more

    - greenmedinfo

    PMID:  Nutrition. 2020 Dec 21 ;84:111119. Epub 2020 Dec 21. PMID: 33476999 Abstract Title:  Antiobesity effects of phytochemicals from an epigenetic perspective. Abstract:  Obesity is an important cause of morbidity and mortality due to its close association with metabolic disorders including diabetes, cardiovascular diseases, and certain types of cancer. According to the Developmental Origins of Adult Health and Disease hypothesis, obesity is likely caused by epigenetic changes. Recent studies have shown an association between epigenetic dysregulation of certain genes and obesity. Due to their reversible characteristic, epigenetic dysregulations can be restored. Restoration of epigenetic dysregulation in obesity-related genes by epigenetic modifiers may be a new treatment option for obesity. Certain phytochemicals such as tea polyphenols, curcumin, genistein, isothiocyanates, and citrus isoflavonoids were shown to prevent weight gain. These phytochemicals are known for their antioxidant effects but they also modify epigenetic mechanisms. These phytochemicals may have a therapeutic potential in the management of obesity. The aim of this study was to review the epigenetic effects of certain phytochemicals on the expression of obesity-related genes. read more Read more

    - greenmedinfo

    PMID:  Am J Clin Nutr. 2021 Jan 29. Epub 2021 Jan 29. PMID: 33515034 Abstract Title:  Vitamin B-6 intake is related to physical performance in European older adults: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study. Abstract:  BACKGROUND: Maintenance of high physical performance during aging might be supported by an adequate dietary intake of niacin, vitamins B-6 and B-12, and folate because these B vitamins are involved in multiple processes related to muscle functioning. However, not much is known about the association between dietary intake of these B vitamins and physical performance.OBJECTIVES: The objectives of this study were to investigate the association between dietary intake of niacin, vitamins B-6 and B-12, and folate and physical performance in older adults and to explore mediation by niacin status and homocysteine concentrations.METHODS: We used baseline data from the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) trial, which included n = 1249 healthy older adults (aged 65-79 y) with complete data on dietary intake measured with 7-d food records and questionnaires on vitamin supplement use and physical performance measured with the short physical… Read more

    - greenmedinfo

    PMID:  J Agric Food Chem. 2021 Feb 9. Epub 2021 Feb 9. PMID: 33557521 Abstract Title:  Vitamin B12 Enriched in Spinach and its Effects on Gut Microbiota. Abstract:  Meat and fermented foods are the main source of vitamin B12 (cobalamin) for human beings. Therefore, daily cobalamin intake is a big problem for vegans. In this study, cyanocobalamin (CNCBL) was added to the culture broth for cobalamin enrichment in spinach. After 36 h of cultivation, the accumulated CNCBL in the spinach leaves (wet weight) was as high as 0.48% (concentration), and the leaves still contained 0.94± 0.11 μg/g CNCBL after boiling, which could provide consumer daily requirement of CNCBL. Because CNCBL supplementation had adverse effects on gut microbiota, this study focused on the effect of the combination of spinach and CNCBL on gut microbiota as well. After the boiled leaves were passed through angastrointestinal tract simulation system, it was found that the spinach protected CNCBL against the low-pH gastric acid. Moreover, compared with the CNCBL supplement group, the relative abundances ofandincreased, and the relative abundance of Proteobacteria, especiallyspp., reduced. Analysis of short-chain fatty acids (SCFAs) showed that cobalamin-rich spinach was positively correlated with, propionate, and butyrate. The results showed that the… Read more

    - greenmedinfo

    PMID:  J Clin Pharm Ther. 2021 Feb 9. Epub 2021 Feb 9. PMID: 33565138 Abstract Title:  B vitamins as a treatment for diabetic pain and neuropathy. Abstract:  WHAT IS KNOWN AND OBJECTIVE: B vitamin therapy is a common treatment for diabetic pain and neuropathy, yet its use remains controversial in patients lacking B vitamin deficiencies. The aim of this review was to summarize the current evidence for the efficacy of B vitamin therapy in diabetic patients with neuropathy.COMMENT: We screened the English literature for clinical studies evaluating B vitamins as a therapy for pain and neuropathy in diabetic patients. We selected 43 relevant studies for qualitative analysis based on our selection criteria. Our survey of the literature revealed substantive heterogeneity with respect to efficacies of reported outcomes, as well as study design. Most beneficial outcomes were reported against baseline measures, with few positive comparisons against placebo. This highlights the need for larger, placebo-controlled studies.WHAT IS NEW AND CONCLUSION: B vitamins should be considered a plausible therapy for diabetic neuropathy, but its overall efficacy remains uncertain and requires further study. read more Read more

    - greenmedinfo

    PMID:  Eur J Nutr. 2021 Feb 22. Epub 2021 Feb 22. PMID: 33619628 Abstract Title:  Vitamin Bmay play a preventive role in esophageal precancerous lesions: a case-control study based on markers in blood and 3-day duplicate diet samples. Abstract:  PURPOSE: It is hypothesized that vitamin Bmay prevent tumor initiation during the early stage of carcinogenesis such as esophageal precancerous lesions (EPL), whereas an excessive level may promote tumor progression during the later stages of carcinogenesis. This study aimed to determine the role of vitamin Bin EPL by detecting vitamin B-related markers in both blood and diet.METHODS: This case-control study based on 3-day duplicated diet samples was conducted in a high-risk area of Huai'an, China. A 100 EPL cases and 100 healthy controls matched by gender, age (± 2 years) and villages were included. Dietary intake of vitamin Band cobalt, plasma cobalt level, the serum levels of vitamin Band transcobalamin II (TC II) were quantitatively analyzed.RESULTS: Dietary vitamin Bintake (p for trend = 0.384) and plasma cobalt level (p for trend = 0.253) were not associated with EPL risk, but high dietary cobalt intake (p for trend = 0.034), increased serum levels of vitamin B(p for trend = 0.036) and TC II (p for trend read more Read more

    - greenmedinfo

    PMID:  Pan Afr Med J. 2020 ;37:280. Epub 2020 Nov 26. PMID: 33598094 Abstract Title:  [Oral diagnosis of vitamin B12 deficiency due to long-term metformin treatment: a case report]. Abstract:  Metformin is the first line treatment for type 2 diabetes. It is also indicated in patients with insulin-resistant type 1 diabetes. It has several benefic effects on carbohydrate metabolism, weight loss and vascular protection. However, it can also cause serious adverse reactions such as the risk of anemia associated with long term use. It has been reported that long-term metformin use might reduce serum vitamin B12 levels. Oral signs combining Hunter glossitis and stomatodynia may be revelatory and lead to early diagnosis of vitamin B12 deficiency. We here report the case of a female patient who had had these oral signs for 2 years and whose laboratory tests revealed normocytic anemia with iron and vitamin B12 deficiency. The diagnosis of vitamin B12 deficiency due to long-term metformin was suspected while excluding other potential causes. Intramuscular hydroxocobalamin injection associated with oral iron led to the normalization of serum levels and to the disappearance of clinical signs. The patient was referred to a specialized center for further etiological assessment. This clinical case… Read more

    - greenmedinfo

    PMID:  J Clin Med. 2020 Nov 11 ;9(11). Epub 2020 Nov 11. PMID: 33187261 Abstract Title:  Efficacy and Safety of Combined Extracts ofandfor Body Fat Reduction in Overweight Women. Abstract:  Obesity is a medical condition that presents excessive fat accumulation with high risk of serious chronic diseases. The aim of this clinical trial is to investigate the anti-obesity effects of(CO) and(RF) on body fat reduction in Korean overweight women. A total of 147 overweight female participants enrolled in double-blinded clinical trial for 12 weeks and 76 participants completed the clinical study. Participants were treated with four CO and RF mixture (COEC; 400 mg per tablet) or four placebo tablets once a day. Obesity associated parameters (body weight, body mass index (BMI), waist circumference, waist-to-hip ratio, body fat percentage and body fat mass) and safety assessment were analyzed. After 12 weeks of COEC treatment, primary outcomes such as body fat percentage (0.76% vs. 0.01%;= 0.022) and mass (1.1 kg vs. 0.5 kg;= 0.049) were significantly decreased. In addition, the results were statistically significant between the COEC and placebo groups, strongly indicated that COEC had anti-obesity effects on overweight women. Secondary outcomes-including body weight, waist and hip circumference, waist-to-hip ratio, body mass… Read more

    - Children's Health Defense

    The numbers reflect the latest data available as of Feb. 12 from the CDC’s Vaccine Adverse Event Reporting System website. Of the 929 reported deaths, about one-third occurred within 48 hours Read more

    - Children's Health Defense
    One-Third of Deaths Reported to CDC After COVID Vaccines Occurred Within 48 Hours of Vaccination

    Originally published on www.childrenshealthdefense.org The numbers reflect the latest data available as of Feb. 12 from the CDC's Vaccine Adverse Event Reporting System website. Of the 929 reported deaths, about one-third occurred within 48 hoursread more Read more

    - BarryBrownstein

    Famed Johns Hopkins doctor Marty Makary recently wondered why "amid the dire Covid warnings, one crucial fact has been largely ignored: Cases are down 77% over the past six weeks." Read more

    - BarryBrownstein
    How and Why Government Creates Disease Panic

    Originally published on www.aier.org Famed Johns Hopkins doctor Marty Makary recently wondered why "amid the dire Covid warnings, one crucial fact has been largely ignored: Cases are down 77% over the past six weeks."read more Read more

    Transfer RNAs (tRNAs) deliver specific amino acids to ribosomes during translation of messenger RNA into proteins. The abundance of tRNAs can therefore have a profound impact on cell physiology, but measuring the amount of each tRNA in cells has been limited by technical challenges. Researchers have now overcome these limitations with mim-tRNAseq, a method that can be used to quantify tRNAs in any organism and will help improve our understanding of tRNA regulation in health and disease. Read more

    In a twist befitting the strange nature of quantum mechanics, physicists have discovered the Hall effect -- a characteristic change in the way electricity is conducted in the presence of a magnetic field -- in a nonmagnetic quantum material to which no magnetic field was applied. Read more

    When Patrick Rottinghaus began college, he had no idea what he wanted to do with his career. He started out as an "Open" major while he explored possibilities. Today, he is helping young people eager to find their place in the world by identifying their strengths and connecting them with careers that match their skill-set, interests and personality. As the father of three children, including a daughter soon to enter high school, he wants to ensure they are equipped with the knowledge and skills to succeed as they prepare to enter the modern workforce. Read more

    For practical applications, two-dimensional materials such as graphene must at some point connect with the ordinary world of 3D materials. Researchers have come up with a way of imaging what goes on at these interfaces, down to the level of individual atoms, with the goal of better controlling these materials' electronic properties. Read more

    Scientists aim to numerically investigative the roles of cooperative effects and disorder in photon escape rates from a cold atomic gas to construct a model that considers the vectorial nature of light. Thus, the study accounts for properties of light, previously neglected. Read more

    The technology, which uses organic light-emitting diodes (OLEDs), is applied in the same way as water transfer tattoos. That is, the OLEDs are fabricated on to temporary tattoo paper and transferred to a new surface by being pressed on to it and dabbed with water. Read more

    Scientists assess the dynamics of positron acoustic waves (PAWS) in EPI plasmas whilst under the influence of magnetic fields, or magnetoplasmas. Read more

    A new study using leading edge technology has shed surprising light on the ancient habitat where some of the first dinosaurs roamed in the UK around 200 million years ago. Read more

    A researcher has discovered that artificial microswimmers accumulate where their speed is minimized, an idea that could have implications for improving the efficacy of targeted cancer therapy. Read more

    Scientists have identified 62 genes that lead to both higher levels of body fat but a lower risk of cardiovascular and metabolic diseases. These genes may help to keep body fat healthy, and open a new avenue for developing drugs that lower the risk of diabetes and heart disease. Read more

    Heart problems cause disturbed gene activity in the brain's memory center, from which cognitive deficits arise. Researchers at the DZNE come to this conclusion based on laboratory studies. They consider that they have found a possible cause for the increased risk of dementia in people with heart problems. Read more

    Aridification in the central plains of China during the early Bronze Age did not cause population collapse, a result that highlights the importance of social resilience to climate change. Instead of a collapse amid dry conditions, development of agriculture and increasingly complex human social structures set the stage for a dramatic increase in human population around 3,900 to 3,500 years ago. Read more

    An insecticide used to control pest infestations on squash and pumpkins significantly hinders the reproduction of ground-nesting bees -- valuable pollinators for many food crops, new research has revealed. Read more

    Eminent scientists warn that key ecosystems around Australia and Antarctica are collapsing, and propose a three-step framework to combat irreversible global damage. Read more

    The leopard stands out as an elusive, versatile, and adaptable animal. Researchers have just published the first genomic data for the African subspecies of the leopard. The results showed an exceptionally high genetic diversity compared to other top predators, transforming our understanding of population dynamics in species at the top of the food chain. Read more

    Paleo-ecologists have demonstrated that the offspring of enormous carnivorous dinosaurs, such as Tyrannosaurus rex may have fundamentally re-shaped their communities by out-competing smaller rival species. Read more

    Programmed magnetic nanobeads paired with an off-the-shelf cellphone and plug-in diagnostic tool can diagnose COVID-19 in 55 minutes or less. Read more

    After traveling several billion miles toward the Sun, a wayward young comet-like object orbiting among the giant planets has found a temporary parking place along the way. The object has settled near a family of captured ancient asteroids, called Trojans, that are orbiting the Sun alongside Jupiter. This is the first time a comet-like object has been spotted near the Trojan population. Read more

    The pandemic has made clear the threat that some viruses pose to people. But viruses can also infect life-sustaining bacteria. A research team has developed a test to determine if bacteria are sick, similar to the one used to test humans for COVID-19. Read more

    As COVID-19 sweeps the world, related viruses quietly circulate among wild animals. A new study shows how SARS-CoV-2, the virus that causes COVID-19, and SARS-CoV-1, which caused the 2003 SARS outbreak, are related to each other. The work helps scientists better understand the evolution of these viruses, how they acquired the ability to infect humans and which other viruses may be poised for human spillover. Read more

    Hospitalized patients with COVID-19 and abnormal sodium levels in the blood have an increased risk of experiencing respiratory failure or dying, according to a new study. Read more

    During the SARS-CoV-2 outbreak, laboratories worldwide have pivoted from their usual research to working to identify new COVID-19 drug and vaccine candidates. This experimental work requires access to clinical isolates and systems that allow genetic manipulation of SARS-CoV-2. A new paper reports an openly available SARS-CoV-2 laboratory research toolkit aimed at increasing availability of these materials. Read more

    Genetically determined vitamin D levels do not have a large effect on risk of type 1 diabetes in Europeans, according to a new study. Read more

    A research team has discovered two new genes potentially involved in Alzheimer's disease. They identified them by exploring which genes were turned on and off in the hippocampus of people who suffered from the disease. Read more

    A new study estimates 64 percent of adult COVID-19 hospitalizations in the U.S. may have been prevented if there were less obesity, hypertension, diabetes, and heart failure. The model suggests notable differences by age and race/ethnicity in COVID-19 hospitalizations related to these conditions. Read more

    The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new study. The research also reveals that the ideal convalescent plasma donor is a recovered COVID-19 patient who is older than 30 and whose illness had been severe. Read more

    Never before in over 1000 years the Atlantic Meridional Overturning Circulation (AMOC), also known as Gulf Stream System, has been as weak as in the last decades. Researchers compiled proxy data, reaching back hundreds of years to reconstruct the AMOC flow history. They found consistent evidence that its slowdown in the 20th century is unprecedented in the past millennium. Read more

    A novel approach to pooled testing could help identify up to 20 times more COVID-19 infections per day than individual testing. Simple pooled designs could be implemented with minimal changes to current testing infrastructures in clinical and public health laboratories. Read more

    Antarctica's northern George VI Ice Shelf experienced record melting during the 2019-2020 summer season compared to 31 previous summers of dramatically lower melt, a new study found. Using satellite observations that detect meltwater on top of the ice and within near-surface snow, the researchers found the most widespread melt of any season. Surface meltwater ponding is potentially dangerous to ice shelves because when these lakes drain, the ice fractures and may trigger ice-shelf break-up. Read more

    Eye conditions that do not cause vision impairment but have economic and social consequences represent a serious and growing challenge for public health services worldwide. Read more

    Insurance policy premiums from the National Flood Insurance Program (NFIP) allow policyholders to maintain a lower, grandfathered rate even when the risk escalates. But as coastal flooding increases due to rising sea level and more intense storms, new research suggests this grandfathered policy could lead to big losses for the NFIP. Read more

    Researchers have boosted the efficiency of conductive inks and devices connecting layered materials flakes with small molecules. Read more

    Pheasants fall into two groups in terms of how they find their way around - and the different types prefer slightly different habitats, new research shows. Read more

    Scientists have captured real-time, high-resolution videos of liquid structures taking shape as nanoparticles form a solid-like layer at the interface between oil and water. Their findings could help advance all-liquid robotics for targeted cancer drug delivery and other applications. Read more

    Chimpanzees and humans 'overlap' in their use of forests and even villages, new research shows. Read more

    When healthcare workers become ill during a disease outbreak, overall case counts and mortality rates may significantly increase, according to a new model. The findings may help to improve interventions that aim to mitigate the effects of outbreaks such as COVID-19. Read more

    A team of scientists has detected the presence of a high-energy neutrino in the wake of a star's destruction as it is consumed by a black hole. This discovery sheds new light on the origins of Ultrahigh Energy Cosmic Rays -- the highest energy particles in the Universe. Read more

    A research team has solved a 150-year-old-mystery after uncovering how fossil dragonfly relatives have been misclassified due to their striking similarity. The researchers have named a new suborder and 16 new species related to damselflies and dragonflies. Read more

    Researchers demonstrate they can engineer botulinum toxin proteins (called proteases) to find new targets with high selectivity, a critical advance toward potential new treatments for everything from neuroregeneration to cytokine storm. Read more

    Using machine learning tools to analyze hundreds of proteins, researchers have identified a group of biomarkers in blood that could lead to an earlier diagnosis of children with autism spectrum disorder (ASD) and, in turn, more effective therapies sooner. Read more

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