Healers & Therapists News

Healers & Therapists News

Healers & Therapists News from June Meagher of AAMARHealing brings you the latest news from sources such as the BBC Health pages as well as the Green Med Info pages and Science Daily, we will be adding more news feeds shortly. Join the conversations on our LinkedIn group which has over 18,000 healers and therapists from around the globe and discover even more news and tips. If you have any news you would like to add to our website, please contact me and I can add it to our blog.

 

    • BBC News - Health
    • GreenMedInfo
    • Latest Science News -- ScienceDaily

    Explore the data on coronavirus in the UK and find out how many cases there are in your area. Read more

    A senior GP says the move would support the "national priority" to vaccinate people quickly. Read more

    In a video, one woman says her family were told she would not survive after giving birth with Covid. Read more

    Alex Bourne says the former health secretary had no involvement is his company winning NHS work. Read more

    Andrew Wheeler is serving 21 years for raping a female patient and sexually abusing another. Read more

    Scientists in South Africa have identified a spike in the numbers catching Covid again. Read more

    All UK adults will be offered a Covid booster, and 12-15-year-olds will be offered a second jab. Read more

    A major report reveals who in society has been hit hardest by each wave of Covid in the UK. Read more

    Researchers say there are signs the boosters would still offer protection against new variant Omicron. Read more

    Omicron is the 13th variant of the Covid-19 virus to receive a Greek name but the pronunciation is up for debate. Read more

    The new Omicron variant has now become dominant, the country's top medical scientists say. Read more

    Face coverings are a legal requirement again in England in shops and on public transport. Read more

    Swabs from PCR tests can help identify omicron, but genetic analysis is needed to confirm it. Read more

    Covid rules are being strengthened in response to the Omicron variant Read more

    Another case of the new variant of Covid-19 has been reported in Scotland, bringing the total to 10. Read more

    It's called sotrovimab and should cut the risk of severe illness, even for new variants such as Omicron, say scientists. Read more

    In an exclusive interview, Dr Albert Bourla says jabs have saved millions of lives. Read more

    Researchers in Cardiff and the US work out how the Covid jab may be linked to the extremely rare clots. Read more

    In an exclusive interview, Albert Bourla hits out at the "rubbish" that has been published about him. Read more

    People should try to reduce Covid transmission so we can all enjoy Christmas "knees up", Therese Coffey says. Read more

    Take lateral flow test before socialising, health secretary suggests at start of two-month booster push. Read more

    EU countries should discuss forced vaccinations to combat the Omicron variant, says Ursula von der Leyen. Read more

    What is the chance that after-work drinks with colleagues will turn into a Covid superspreader event? Read more

    The heath secretary says people should however be "a bit cautious". Read more

    Dr Rupert Whitaker lived through the Aids epidemic in London in the 1980s. Read more

    Boris Johnson says people will be worked through by age group - as at other stages of the Covid vaccine roll-out. Read more

    All children aged 12 to 15 are being offered two doses of Covid vaccine. Read more

    A new Covid variant has emerged that looks worryingly different to the one vaccines were designed to fight. Read more

    The new variant's genetic profile has raised concerns, but there's a shortage of real-world data. Read more

    People in England are being advised to test for Covid before going to crowded places this winter. Read more

    An Edinburgh mother-of-two thought she had laryngitis when her voice turned to a "papery whisper". Read more

    Dr Siaron West says specialist training made "at least half a dozen of my patients" spring to mind. Read more

    All 16 and 17 year-olds in the UK can now have a second dose 12 weeks after the first. Read more

    Primary care staff in Bristol say they have never seen pressure like this before - and winter hasn't even started yet. Read more

    An intensive care consultant says most Covid cases are those aged between 40 and 50. Read more

    Is the effectiveness of Covid vaccines waning over time? We look at how much protection being double vaccinated offers. Read more

    MP Simon Clarke opted out of a Downing Street Budget photograph because of agoraphobia - what does it feel like to live with it? Read more

    A new cough, fever and change in smell or taste are the key symptoms of coronavirus. Read more

    Psychologists say men need to be part of a group in order to vent their feelings and emotions. Read more

    There are fears that this version of coronavirus, first identified in South Africa, is Read more

    - greenmedinfo

    PMID:  Cureus. 2021 Oct ;13(10):e18882. Epub 2021 Oct 19. PMID: 34804730 Abstract Title:  Saudi Honey: A Promising Therapeutic Agent for Treating Wound Infections. Abstract:  Treatment of wounds, especially chronic ones, is a major challenge in healthcare, with serious clinical and economic burdens. Multiple treatment approaches, including the usage of silver and iodine, have dramatically improved wound healing and reduced the incidence of infection. However, once infected by drug-resistant bacteria, treatment of wounds becomes a serious complication, with limited availability of effective antibiotic drugs, leading to high morbidity and mortality. Therefore, alternative therapeutic agents are required to address this gap in wound management. The introduction of manuka honey as a therapeutic agent against infected wounds was the result of extensive research about its activity against both planktonic and biofilm bacterial growth. Likewise, several types of Saudi honey (e.g., Sidr and Talh) showed promising in vitro and in vivo antimicrobial activity against wound pathogens. This short review summarizes literature that investigated the activity of common types of Saudi honey in relation to wound infections and explores their clinical utility. read more Read more

    - greenmedinfo

    PMID:  Food Funct. 2021 Nov 29 ;12(23):12059-12076. Epub 2021 Nov 29. PMID: 34783324 Abstract Title:  Royal jelly from different floral sources possesses distinct wound-healing mechanisms and ingredient profiles. Abstract:  In recent years, population aging together with the increased prevalence of diabetes and obesity has fuelled a surge in the instances of cutaneous non-healing wounds. Royal jelly (RJ) is a traditional remedy for wound repair; however, the subjacent mechanisms and ingredient profiles are still largely unknown. Our previous study found thatBl. RJ (CmRJ-Zj) possessed superior wound healing-promoting effects on both theandmodels thanL. RJ (BnRJ-Zj). This study conducted an in-depth investigation on the wound-repairing mechanisms of CmRJ-Zj and BnRJ-Zj to explain the previously observed phenomenon and also comprehensively characterized their constituents. It was found that chestnut RJ could enhance cutaneous wound healing by boosting the growth and mobility of keratinocytes, modulating the expression of aquaporin 3 (AQP3), regulating MAPK and calcium pathways, and mediating inflammatory responses. By employing LC-MS/MS-based proteomic and metabolomic techniques, the comprehensive molecules present in CmRJ-Zj and BnRJ-Zj were elucidated, resulting in a clear discrimination from each other. A total of 15 and 631 differential proteins and compounds were identified, and 217 proteins were newly found in RJ proteome.… Read more

    - greenmedinfo

    PMID:  Physiol Rep. 2021 Nov ;9(22):e15117. PMID: 34806344 Abstract Title:  Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis. Abstract:  Endometriosis is the abnormal growth of endometrial tissue. The goals of the study are: (1) Is any correlation between endometriosis pain and neurotrophins in the serum, dorsal root ganglion (DRG), and peritoneal fluid (PF) in rat models of experimental endometriosis?, (2) Possible therapeutic effects of royal jelly (RJ) on pain scores, size of endometriotic lesion, and neurotrophic factors. Forty-eight Sprague Dawley female rats weighing 205.023 ± 21.54 g were maintained in a standard condition. The rats were randomly divided into one of the six groups: Control (no intervention), Sham-1 (remove of uterine horn), RJ (administration of 200 mg/kg/day RJ for 21 days), Endometriosis (induction of endometriosis), Treatment (induction of endometriosis+administration of 200 mg/kg/day RJ for 21 days), and Sham-2 (induction of endometriosis+administration of water). Formalin test performed for pain evaluation. The levels of Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), substance P, and calcitonin gene-related peptide (CGRP) were measured by enzyme-linked immunosorbent assay. The mean pain scores in all three phases of the formalin test were significantly increased by endometriosis induction (p read more Read more

    - greenmedinfo

    PMID:  Brain Behav. 2021 Nov 22:e2423. Epub 2021 Nov 22. PMID: 34807519 Abstract Title:  Neurogenesis in the rat neonate's hippocampus with maternal short-term REM sleep deprivation restores by royal jelly treatment. Abstract:  BACKGROUND: Numerous studies have shown the effects of rapid eye movement sleep deprivation (REM-SD) on behavior and brain structures. The impact of REM-SD on learning and memory, thus neurogenesis, has been reported in previous studies. Royal jelly (RJ) is known as the wealthiest biological nutrient with various physiological properties. This study aimed to study the possible effect of RJ on neurogenesis of the rat hippocampus neonates following exposure of mother to REM-SD during pregnancy.METHODS: Thirty neonate rats from 15 pregnant Wistar rats were used. To induce REM-SD, the flowerpot method was used. The pregnant rats were divided into five groups (n = 3): group 1, no treatment; group 2, REM-SD; groups 3, 4, and 5, REM-SD +RJ. The former group received 72 h REM-SD during pregnancy (days 7, 14, 21), and the latter group received REM-SD + RJ (three trial groups). At week 4, the rat neonates of all groups were sacrificed (n = 6 each group). Their brains were fixed, removed, and prepared for Nissl and Hoechst 33342 staining. By using real… Read more

    - greenmedinfo

    PMID:  Support Care Cancer. 2021 Nov 25. Epub 2021 Nov 25. PMID: 34822003 Abstract Title:  Comparative study of royal jelly, propolis, and photobiomodulation therapies in 5-fluorouracil-related oral mucositis in rats. Abstract:  PURPOSE: This study aimed to evaluate the effects and mechanisms of action of royal jelly (RJ) and propolis compared to photobiomodulation therapy (PBMT) in an animal model of 5-fluorouracil-related oral mucositis (OM).METHODS: Seventy-two male Wistar rats were randomly allocated to four groups (n = 18 each): control (no treatment), PBMT (intraoral laser, 6 J/cm), RJ, and propolis. On days 0 and 2, the animals received an injection of 5-fluorouracil (5-FU). The buccal mucosa was scratched (days 3 and 4) and the treatments were initiated on day 5. Six animals of each group were euthanized on days 8, 10, and 14. Phytochemical analysis (thin-layer chromatography, TLC) and clinical, histopathological, and immunohistochemical analysis of pS6, pAKT, and NF-κB were performed, and oxidative stress markers were also investigated.RESULTS: TLC revealed the presence of large amounts of sucrose (Rf 0.34) in RJ and of flavonoids in propolis. Lower clinical OM scores were observed on day 8, and improved morphological data were observed on day 10 in the PBMT, RJ, and propolis groups (p read more Read more

    - greenmedinfo

    PMID:  Acta Pharm Sin B. 2021 Sep ;11(9):2880-2899. Epub 2021 Mar 9. PMID: 34589402 Abstract Title:  Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation. Abstract:  Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 inflammasome has been considered to be a potential therapy, the underlying mechanism through which pathway the intestinal inflammation is modulated remains controversial. By focusing on the flavonoid lonicerin, one of the most abundant constituents existed in a long historical anti-inflammatory and anti-infectious herbThunb., here we report its therapeutic effect on intestinal inflammation by binding directly to enhancer of zeste homolog 2 (EZH2) histone methyltransferase. EZH2-mediated modification of H3K27me3 promotes the expression of autophagy-related protein 5, which in turn leads to enhanced autophagy and accelerates autolysosome-mediated NLRP3 degradation. Mutations of EZH2 residues (His129 and Arg685) indicated by the dynamic simulation study have found to greatly diminish the protective effect of lonicerin. More importantly,studies verify that lonicerin dose-dependently disrupts the NLRP3-ASC-pro-caspase-1 complex assembly and alleviates colitis, which is compromised by administration of EZH2 overexpression plasmid. Thus, these findings together put forth the stage for further considering lonicerin as an anti-inflammatory epigenetic agent… Read more

    - greenmedinfo

    PMID:  Anim Cells Syst (Seoul). 2021 ;25(5):272-282. Epub 2021 Sep 8. PMID: 34745434 Abstract Title:  Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice. Abstract:  (Poaceae), also known as purple corn, is an annual herbaceous plant that is grown as food for human consumption in a variety of forms, including cooking oils and sweeteners in processed food and beverage products. The purpose of this study was to determine whether a novel purple corn extract, FB801, might have an anti-atopic dermatitis (AD) effect on AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) in BALB/c mice. Topical sensitization (1%) and challenge (0.3%) by DNCB were performed on the dorsal skin and right ear of BALB/c mice to induce AD. Following FB801 and dexamethasone administered orally, the severity of skin lesions was examined macroscopically and histologically. Serum levels of immunoglobulin E (IgE) and various cytokines were determined by enzyme-linked immunosorbent assay. Oral administration of FB801 significantly reduced typical symptoms of AD (erythema/bleeding, swelling, molting/erosion and scaling/drying), scratching frequencies, and the recruitment of inflammatory and mast cells. In addition, FB801 suppressed serum levels of IgE and T helper (Th)2 type cytokines such as interleukin (IL)-4 and IL-10 in DNCB-treated BALB/c mice. Furthermore, FB801… Read more

    - greenmedinfo

    PMID:  Curr Top Behav Neurosci. 2021 Nov 23. Epub 2021 Nov 23. PMID: 34811715 Abstract Title:  Psilocybin for the Treatment of Depression: A Promising New Pharmacotherapy Approach. Abstract:  Depression is highly prevalent and represents the leading cause of global disability and primary contributor to overall global burden of disease. Several lines of evidence from early-phase experimental trials suggest that serotonergic psychedelics, particularly psilocybin, with therapeutic support show great promise in the treatment of depression with large effect sizes. Neuroimaging data have also revealed the dynamic effects of psilocybin on functional activity within and between neural regions. This chapter reviews the methods and findings from three small human laboratory clinical trials examining the effects of psilocybin therapy for patients with major depressive disorder and treatment-resistant depression. Insights from functional magnetic resonance imaging and qualitative analyses are also presented, as well as a discussion of study limitations and future directions for the research. read more Read more

    - greenmedinfo

    PMID:  Curr Top Behav Neurosci. 2021 Nov 11. Epub 2021 Nov 11. PMID: 34761362 Abstract Title:  Ayahuasca for the Treatment of Depression. Abstract:  Ayahuasca, the vine of the souls in Quechua, is a psychedelic brew with a few formulations that most often include the bark of a liana in the Malpighiaceae family (Banisteriopsis caapi), with leaves from a shrub in the coffee family Rubiaceae (Psychotria viridis). Mixed with water and boiled for hours or days, it produces a brownish-colored liquid with a strong and characteristic taste. Ayahuasca contains the psychedelic tryptamine N,N-Dimethyltryptamine (DMT), and Monoamine Oxidase Inhibitors (MAOi), and in the past few years, it has been tested. In recent years its antidepressant properties have been put to the test. Evidence from open and randomized placebo-controlled clinical trials has shown encouraging results, indicating significant and rapid antidepressant effects, starting as early as 1 day after the ayahuasca intervention. In addition, we have explored the nature of these effects using multivariate measures. In this article, we will review the history, pharmacology, clinical trials, and clinical and behavioral markers associated with the antidepressant effects of ayahuasca. read more Read more

    - greenmedinfo

    PMID:  J Ethnopharmacol. 2021 Nov 22 ;285:114865. Epub 2021 Nov 22. PMID: 34822961 Abstract Title:  Ayahuasca blocks ethanol preference in an animal model of dependence and shows no acute toxicity. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Ayahuasca, a psychoactive beverage prepared from Banisteriopsis caapi and Psychotria viridis, is originally used by Amazon-based indigenous and mestizo groups for medicinal and ritualistic purposes. Nowadays, ayahuasca is used in religious and shamanic contexts worldwide, and preliminary evidence from preclinical and observational studies suggests therapeutic effects of ayahuasca for the treatment of substance (including alcohol) use disorders.AIM OF THE STUDY: To investigate the initial pharmacological profile of ayahuasca and its effects on ethanol rewarding effect using the conditioned place preference (CPP) paradigm in mice.MATERIALS AND METHODS: Ayahuasca beverage was prepared using extracts of B. caapi and P. viridis, and the concentration of active compounds was assessed through high performance liquid chromatography (HPLC). The following behavioral tests were performed after ayahuasca administration: general pharmacological screening (13, 130, or 1300 mg/kg - intraperitoneally - i.p., and 65, 130, 1300, or 2600 mg/kg - via oral - v.o.); acute toxicity test with elevated doses (2600 mg/kg - i.p., and 5000 mg/kg - v.o.); motor activity, motor coordination, and hexobarbital-induced sleeping time potentiation (250, 500,… Read more

    - greenmedinfo

    PMID:  J Neurochem. 2021 Nov 24. Epub 2021 Nov 24. PMID: 34816433 Abstract Title:  Psychedelic-Inspired Approaches for Treating Neurodegenerative Disorders. Abstract:  Psychedelics are increasingly being recognized for their potential to treat a wide range of brain disorders including depression, post-traumatic stress disorder (PTSD), and substance use disorder. Their broad therapeutic potential might result from an ability to rescue cortical atrophy common to many neuropsychiatric and neurodegenerative diseases by impacting neurotrophic factor gene expression, activating neuronal growth and survival mechanisms, and modulating the immune system. While the therapeutic potential of psychedelics has not yet been extended to neurodegenerative disorders, we provide evidence suggesting that approaches based on psychedelic science might prove useful for treating these diseases. The primary target of psychedelics, the 5-HTreceptor, plays key roles in cortical neuron health and is dysregulated in Alzheimer's disease. Moreover, evidence suggests that psychedelics and related compounds could prove useful for treating the behavioral and psychological symptoms of dementia (BPSD). While more research is needed to probe the effects of psychedelics in models of neurodegenerative diseases, the robust effects of these compounds on structural and functional neuroplasticity and inflammation clearly warrant further investigation. read more Read more

    - greenmedinfo

    PMID:  Curr Opin Psychiatry. 2022 Jan 1 ;35(1):22-29. PMID: 34855694 Abstract Title:  Psychedelic medicines for mood disorders: current evidence and clinical considerations. Abstract:  PURPOSE OF REVIEW: Despite advances in treatment modalities for mood disorders over recent decades, further therapeutic options are still required. Increased research is occurring, with the pursuit of psychedelic-based pharmacotherapies for a range of mood disorders and other conditions.RECENT FINDINGS: Serotonergic psychedelics have been found to modulate brain networks underlying various psychiatric disorders, as well promoting neurogenesis and neuroplasticity. Randomized placebo-controlled trials have found psilocybin with psychological support effective at treating depression, including treatment-resistant depression; with emergent research also signalling N,N-dimethyltryptamine/ayahuasca also as a potential option for the treatment of depression. Lysergic acid diethylamide has been found to have anxiolytic effects, whereas 3,4-methylenedioxymethamphetamine (MDMA) has been used effectively to treat post-traumatic stress disorder (PTSD), with Phase III clinical trial evidence. Microdosing of psychedelics is a growing phenomenon that has shown benefits in some preclinical data; however, a recent self-directed controlled trial reported no evidence of improved mood.SUMMARY: Current research with medicinal psychedelics, usually as an adjunct to psychotherapy, has shown encouraging results in treating mood disorders. However, there are challenges regarding blinding and sample sizes remain small,… Read more

    - greenmedinfo

    PMID:  Biochem Biophys Rep. 2021 Dec ;28:101144. Epub 2021 Sep 28. PMID: 34622038 Abstract Title:  β-elemene combined with temozolomide in treatment of brain glioma. Abstract:  Temozolomide (TMZ) is a widely used chemotherapeutic agent for malignant glioma.β-Elemene has been reported to have the ability of passing through the blood-brain barrier and reverse multidrug resistance. In the present study, transport of drugs through the in vitro blood-brain barrier (BBB) model also suggested that β-elemene can assist in TMZ transport to the brain. Plasmaand brain pharmacokinetics demonstrated that when β-elemene is used in combination with TMZ, the metabolic rate of TMZ in plasma is slowed, and mean residence time (MRT) in brain is prolonged. The brain tissue distribution at 1 h indicated that the combination of TMZ and β-elemene promotes the distribution of β-elemene in the brain but slightly reduces the distribution of TMZ in the brain. Furthermore the antitumor effect and toxicity in vivo were also investigated. The combination of β-elemene and TMZ was well tolerated and significantly inhibited tumor growth in glioma xenografts. In summary, the present study indicates a synergistic antitumor effect of β-elemene and TMZ in glioma. read more Read more

    - greenmedinfo

    PMID:  Bioengineered. 2021 12 ;12(1):7794-7804. PMID: 34704542 Abstract Title:  Baicalin suppresses autophagy-dependent ferroptosis in early brain injury after subarachnoid hemorrhage. Abstract:  Early brain injury, characterized by massive cell apoptosis or death, is identified as a critical pathophysiological process during subarachnoid hemorrhage (SAH). Ferroptosis, a class of autophagy-dependent cell death discovered in 2012, is induced by iron-dependent lipid peroxidation accumulation. The present study was designed to study the role of baicalin in autophagy-dependent ferroptosis in early brain injury after SAH. Neurological scores and brain water content were measured to evaluate brain injury. Measurement of iron ion, malondialdehyde (MDA), lipid reactive oxygen species was conducted for ferroptosis evaluation. Immunofluorescence staining, western blotting, and flow cytometry analysis were used to evaluate autophagy and apoptosis. First, we observed that, compared with sham rats, SAH rats had lower neurobehavioral scores. Next, baicalin was proven to decrease the Fe, malondialdehyde, and ROS levels in the brain tissues of rats. Also, baicalin was confirmed to suppress the beclin1, LC3-II, and LC3-I protein levels in rat brain tissues. Moreover, we found that baicalin inhibited neuronal apoptosis. Finally, the effects of baicalin on brain injury in the SAH rats were verified. Overall, our results demonstrated that baicalin suppressed autophagy-dependent… Read more

    - greenmedinfo

    PMID:  J Food Biochem. 2021 11 ;45(11):e13977. Epub 2021 Oct 19. PMID: 34664287 Abstract Title:  Antiproliferative Wnt inhibitor wogonin prevents eryptosis following ionophoric challenge, hyperosmotic shock, oxidative stress, and metabolic deprivation. Abstract:  Anemia is a common complication of chemotherapy and may arise due to premature or suicidal death of red blood cells (RBCs). Prevention of RBC death thus lends itself as a promising strategy to counteract anemia. Wogonin (WGN; 5,7-dihydroxy-8-methoxyflavone) is a Wnt inhibitor derived from Scutellaria baicalensis plant with potent cytotoxic and antitumor potential. However, the nature of interaction of WGN with human RBCs is unknown. RBCs from healthy participants were exposed to different hemolytic and eryptotic stimuli for 24 or 48 hr at 37°C in the presence and absence of 100 μM WGN. Calcium overload was induced by 2 μM ionomycin, hyperosmotic shock with excessive sucrose, oxidative stress by 2-phenethyl isothiocyanate (PEITC), and metabolic deprivation by exclusion of glucose. Hemolysis was estimated from extracellular hemoglobin, phosphatidylserine (PS) exposure by Annexin V-FITC, intracellular calcium by Fluo4/AM, and oxidative stress by 2',7'-dichlorodihydrofluorescein diacetate (HDCFDA). While WGN did not rescue the cells from the hemolytic activity of ionomycin, it reduced PS externalization by interfering with calcium influx under both ionomycin treatment and metabolic exhaustion.… Read more

    - greenmedinfo

    PMID:  Cell Mol Biol (Noisy-le-grand). 2021 Sep 29 ;67(2):1-7. Epub 2021 Sep 29. PMID: 34817345 Abstract Title:  Regulation of cell signaling pathways by Wogonin in different cancers: Mechanistic review. Abstract:  Natural products have historically been invaluable as a premium source of therapeutic agents. Recent advancements in genomics and structural biology have portrayed a high-resolution landscape of the diversity of proteins targeted by pharmacologically active products from natural sources. Natural product research has generated valuable wealth of information and cutting-edge research-works have leveraged our conceptual knowledge altogether to a new level. Wogonin (5,7-dihydroxy-8-methoxyflavone) is an O-methylated flavone and has attracted noteworthy appreciation because of its ability to pharmacologically target plethora of cell signaling pathways in different cancers. In this mini-review, we have gathered scattered pieces of available scientific evidence to summarize how wogonin pharmaceutically targeted Wnt/?-catenin, JAK/STAT, VEGF/VEGFR and TRAIL-driven apoptotic pathways in wide variety of cancers. We have also critically analyzed how wogonin prevented carcinogenesis and metastasis in tumor-bearing mice. Although researchers have uncovered pleiotropic role of wogonin in the regulation of different oncogenic signaling cascades but there are visible knowledge gaps in our understanding related to regulation of non-coding RNAs by wogonin. Future studies must converge on the unraveling… Read more

    - greenmedinfo

    PMID:  Phytomedicine. 2022 Jan ;94:153823. Epub 2021 Oct 25. PMID: 34763315 Abstract Title:  Baicalin suppresses the progression of Type 2 diabetes-induced liver tumor through regulating METTL3/mA/HKDC1 axis and downstream p-JAK2/STAT1/clevaged Capase3 pathway. Abstract:  BACKGROUND: Epidemiological and clinical evidence suggests that diabetes increases the risk of liver cancer. Although the co-occurrence of type 2 diabetes (T2D) and liver cancer is becoming more frequent, the underlying mechanisms remain unclear. Even though baicalin, extensively used in traditional Chinese medicine (TCM), can control T2D and inhibit liver cancer separately, minimal research is available regarding its possible effect on T2D-induced liver cancer. Thus, in the present study, we aimed to investigate the role of baicalin in T2D-induced hepatocellular cancer, and for the first time, we particularly emphasized the regulation of baicalin in genes RNA mA in hepatocellular cancer.METHODS: Here, we constructed a cell culture model under a high concentration of glucose and a T2D-induced liver tumor model to evaluate the in vitro and in vivo role of baicalin in T2D-induced liver cancer progression. After confirming the suppressive effect of baicalin and the HKDC1 antibody on T2D-induced liver tumors, the epigenetic alterations (DNA 5mC and RNA mA) of the baicalin-regulated HKDC1 gene were detected using MS… Read more

    - greenmedinfo

    PMID:  Brain Res. 2022 Jan 1 ;1774:147723. Epub 2021 Nov 12. PMID: 34780748 Abstract Title:  Baicalin suppresses neuron autophagy and apoptosis by regulating astrocyte polarization in pentylenetetrazol-induced epileptic rats and PC12 cells. Abstract:  Epilepsy is a common chronic neurological disorder worldwide, but its entire pathology remains unknown. The purpose of this study was to explore the antiepileptic effect of baicalin (BAL), the main bioactive component of scutellaria. We isolated astrocytes from neonatal rats and astrocytes were identified by glial fibrillary acidic protein (GFAP) immunostaining. The viability and phenotype of astrocytes were determined by Cell Counting Kit-8 (CCK-8) and immunofluorescence staining, respectively. For investigating the effect of BAL on the autophagy in A1 astrocytes treated PC12 cells, expression of light chain 3B (LC3-B) and sequestosome 1 (P62) was analyzed by immunofluorescence staining and apoptosis by acridine orange/ethidium bromide (AO/EB) staining, respectively. For animal experiments, pentylenetetrazol (PTZ)-induced epileptic model was used to explore the antiepileptic effect of BAL. The results showed that BAL reduced lipopolysaccharide (LPS)-induced complement C3 (C3, a marker of A1 astrocytes) + A1 cells and decreased autophagy and apoptosis in PC12 cells. Further findings showed seizure grade and latency were positively correlated with GFAP+/C3 + A1 cells' infiltration in interstitial astrocytes. After BAL… Read more

    - jonrappoport

    Nothing mutates faster than a non-virus, except perhaps Tony Fauci's pronouncements about the "pandemic." Read more

    - jonrappoport
    The Omicron Deception; How Long Can They String Out the Mutation-Stories?

    Originally published on www.nomorefakenews.com Nothing mutates faster than a non-virus, except perhaps Tony Fauci's pronouncements about the "pandemic." In early 2020, it all started with a "virus" no one had isolated. Meaning a phantom, a fake, a con, a non-entity. NO VIRUS TO THIS DAY.read more Read more

    - greenmedinfo

    n/a PMID:  Front Pharmacol. 2021 ;12:761763. Epub 2021 Nov 8. PMID: 34819863 Abstract Title:  Baicalin Enhanced Oral Bioavailability of Sorafenib in Rats by Inducing Intestine Absorption. Abstract:  Sorafenib (SOR) is an oral, potent, selective, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used as the first-line therapy for advanced hepatocellular carcinoma (HCC). Baicalin (BG) is used as adjuvant therapy for hepatitis, which accounts for the leading cause of the development of HCC, and is commonly coadministered with SOR in clinic. The purpose of the current study was to characterize the pharmacokinetic changes of SOR and the potential mechanism when SOR is administered concomitantly with BG in rats for single and multiple doses.Parallel randomized pharmacokinetic studies were performed in rats which received SOR (50 mg/kg,) alone or coadministered with BG (160 mg/kg,) for single and multiple doses (7 days). Plasma SOR levels were quantified by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Rat liver microsomes (RLMs) which isolated from their livers were analyzed for CYP3A and SOR metabolism activities. The inhibitory effect of BG on the metabolism of SOR was also assessed in pooled human liver microsomes (HLMs). The effects of BG on the intestine absorption behaviors of SOR were assessed in thesingle-pass rat… Read more

    - greenmedinfo

    PMID:  Food Funct. 2021 Nov 25. Epub 2021 Nov 25. PMID: 34821232 Abstract Title:  Baicalin inhibits APEC-induced lung injury by regulating gut microbiota and SCFA production. Abstract:  Baicalin is a plant-derived flavonoid fromGeorgi with multiple bioactivities and has a protective effect against avian pathogenic(APEC) infection. However, the underlying mechanism of baicalin against APEC infection is still unknown. Therefore, we aimed to explore whether the protective effects and mechanisms of baicalin on APEC-induced lung inflammation were related to the regulation of gut microbiota. The results showed that baicalin significantly reduced APEC colonization and pro-inflammatory cytokines production, and additionally recovered air-blood barrier integrity in the lungs after APEC challenge. However, depletion of gut microbiota significantly weakened the protective effects of baicalin against APEC infection as mentioned above. Furthermore, baicalin markedly restored the dysbiosis of gut microbiota induced by APEC as well as increased the abundance of short chain fatty acid (SCFA)-producing bacteria and the production of SCFAs including acetic acid, propionic acid and butyric acid, especially acetic acid. In addition, the concentrations of acetic acid and its receptor free fatty acid receptor 2 (FFAR2) were significantly upregulated in the lung tissues after baicalin treatment. In conclusion, gut microbiota played a key role… Read more

    - greenmedinfo

    PMID:  Mil Med. 2021 Nov 26. Epub 2021 Nov 26. PMID: 34850063 Abstract Title:  Physical Exercise as Treatment for PTSD: A Systematic Review and Meta-Analysis. Abstract:  INTRODUCTION: Post-traumatic stress disorder (PTSD) is a cluster of physical and psychiatric symptoms following military or civilian trauma. The effect of exercise on PTSD symptoms has previously been investigated in several studies. However, it has not been fully determined what type of exercise most impacts PTSD symptoms. The aim of the present study was to systematically review the effects of different types of exercise on PTSD symptom severity and symptoms of coexisting conditions in adults.MATERIALS AND METHODS: Electronic searches were conducted in the databases PubMed, APA PsycInfo, and SportDiscus, from database inception up until February 1, 2021. Inclusion criteria were randomized controlled trials published in English, participants having a PTSD diagnosis or clinically relevant symptoms, and participants randomly allocated to either a non-exercising control group or an exercise group. Data concerning the number of participants, age, exercise type and duration, PTSD symptom severity (primary outcome), and symptoms of coexisting conditions (secondary outcomes) were extracted. The subgroup analysis included high or low training dose, military trauma versus non-military trauma, the type of intervention (yoga versus… Read more

    - greenmedinfo

    PMID:  BMC Sports Sci Med Rehabil. 2021 Nov 29 ;13(1):151. Epub 2021 Nov 29. PMID: 34844646 Abstract Title:  Indoor cycling training in rehabilitation of patients after myocardial infarction. Abstract:  BACKGROUND: Standard endurance training used from the second stage of cardiac rehabilitation has many common features with indoor cycling training which is used in fitness clubs. In the study, an attempt was made to evaluate the usefulness of this form of training in a 24-day rehabilitation program for patients after myocardial infarction. The study examined a group of 64 patients (51.34 ± 8.02 years) who were divided into two groups: the IC group (32 patients aged 53.40 ± 4.31 years) with indoor cycling training instead of standard endurance training; and the ST group (32 patients aged 55.31 ± 6.45 years) performing standard training. The level of exercise tolerance (cardiopulmonary exercise testing on a treadmill-Bruce's protocol), hemodynamic indicators of the left ventricle (echocardiography) and blood lipid profile (laboratory test) were assessed.RESULTS: In the IC group there was a significant increase in the test duration (9.21 ± 2.02 vs 11.24 ± 1.26 min; p read more Read more

    - greenmedinfo

    PMID:  Antioxidants (Basel). 2021 Oct 29 ;10(11). Epub 2021 Oct 29. PMID: 34829602 Abstract Title:  Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Abstract:  It is well-established that green tea supplementation has antioxidant properties. However, whether green tea supplementation leads to oxidative stress reduction remains unclear, as clinical investigations on this subject have yielded inconsistent outcomes. Consequently, we aimed to determine the effects of green tea supplementation on oxidative stress in adults. A systematic search of English language publications up to 21 August 2021 was carried out in PubMed, Scopus, Embase, and ISI Web of Science, utilizing pertinent keywords. These searches included randomized controlled trials (RCTs) evaluating the relationship between green tea supplementation, malondialdehyde (MDA), and total antioxidant capacity (TAC) in adults. A random-effects model was used to estimate the weighted mean difference (WMD) and 95% confidence intervals (95% CI). Meta-regression and non-linear dose-response analyses were performed to investigate the association between the dosage of green tea (mg/day) and the duration of the intervention (weeks) with pooled effect size. Sixteen RCTs with seventeen arms including 760 participants met the inclusion criteria. Our results indicated that green tea supplementation had… Read more

    - greenmedinfo

    PMID:  Bioorg Med Chem Lett. 2015 Jul 15 ;25(14):2834-6. Epub 2015 May 6. PMID: 25981688 Abstract Title:  A new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth. Abstract:  A new octaketide, named cytosporone V (1), and two other known phenylethanoid glycosides (2-3), were isolated from the aerial parts of Pogostemon cablin (Blanco) Benth. The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR and HR-MS. Compounds 1-3 displayed weak antibacterial activity against two gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus. All isolates were also evaluated for their antiproliferative activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15). Compounds 2 and 3 showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values ranging from 2.73 to 9.52μM. read more Read more

    - greenmedinfo

    PMID:  Int J Mol Sci. 2019 Aug 21 ;20(17). Epub 2019 Aug 21. PMID: 31438541 Abstract Title:  Pachypodol, a Methoxyflavonoid Isolated fromBentham Exerts Antioxidant and Cytoprotective Effects in HepG2 Cells: Possible Role of ERK-Dependent Nrf2 Activation. Abstract:  Oxidative stress has been implicated in the pathogenesis of many diseases including chronic liver diseases. Nrf2 is a master transcriptional factor regulating the induction of cellular antioxidant defense systems. Here, the Nrf2-activating effect of the crude methanol extract of dried leaves ofBentham was demonstrated by measuring the antioxidant response element (ARE)-driven luciferase activity and pachypodol, 4',5-dihydroxy-3,3',7-trimethoxyflavone, was isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. To our knowledge, this is the first study to evaluate the antioxidant and cytoprotective effects of pachypodol in HepG2 cells as well as the underlying molecular mechanisms. Indeed, pachypodol protected HepG2 cells from cell death caused by-butylhydroperoxide-induced oxidative stress and also attenuated ROS production. The ability of pachypodol to activate Nrf2/ARE pathway was further confirmed by observing Nrf2 expression in nuclear fraction, mRNA levels of Nrf2 target antioxidants, and cellular glutathione content in HepG2 cells. Extracellular signal-regulated kinase (ERK) is one of the important kinases involved in Nrf2 activation. Pachypodol increased ERK phosphorylation and ERK inhibition… Read more

    - greenmedinfo

    PMID:  Biomed Pharmacother. 2017 May ;89:544-548. Epub 2017 Mar 1. PMID: 28259096 Abstract Title:  Phytochemicals of Pogostemon Cablin (Blanco) Benth. aqueous extract: Their xanthine oxidase inhibitory activities. Abstract:  Bioassay-guided fractionation of the aerial part of P. cablin revealed that fraction A3 of the water extract exhibited significant xanthine oxidase inhibitory activities (IC=85.42±1.71μg/mL), which further led to the isolation of ten more bioactive compounds, including two new compounds (1 and 2). The structures of compounds 1 and 2 were elucidated by extensive spectral analysis. It is revealed that flavonoids and phenolic compounds were found to be responsible for the xanthine oxidase inhibitory activities of P. cablin. Especially, rosmarinic acid was found to be with potent XO inhibitory activity (IC=8.53±0.91μg/mL). read more Read more

    - greenmedinfo

    PMID:  Chin J Integr Med. 2021 Feb ;27(2):125-130. Epub 2016 Apr 13. PMID: 27080999 Abstract Title:  In Vitro and In Vivo Antibacterial Activity of Patchouli Alcohol from Pogostemon cablin. Abstract:  OBJECTIVE: To investigate the antibacterial activity of patchouli alcohol (PA) against 127 bacteria strains, including the common bacteria and drug-resistant bacteria strains both in the in vitro and in vivo tests.METHODS: For the in vitro trial, the antibacterial property of PA against 107 Gram-positive and 20 Gram-negative bacteria strains was screened by agar double dilution method. For the in vivo trial, specific pathogen free Kunming strain of both male and female white mice, were used to test the protective ability of PA after being injected with the median lethal dose of the tested strains.RESULTS: PA possessed antibacterial activity against all the tested 127 strains. In the in vitro test, PA could inhibit both Gram-negative bacteria (25-768μg/mL) and Gram-positive bacteria (1.5-200μg/mL). Particularly, PA was active against some drug-resistant bacteria like methicillin-resistant Staphylococcus aureus (MRSA). PA also exhibited in vivo anti-MRSA activity in mice via intraperitoneal injection. PA could protect mice entirely infected with MRSA at 100 and 200 mg/kg, while 80% mice injected with MRSA could be protected at a low… Read more

    - greenmedinfo

    PMID:  Evid Based Complement Alternat Med. 2020 ;2020:9758156. Epub 2020 Sep 9. PMID: 32963578 Abstract Title:  Extract ofPossesses Potent Anticancer Activity against Colorectal Cancer Cells In Vitro and In Vivo. Abstract:  (PCa), an herb used in traditional Chinese medicine, is routinely used in the amelioration of different types of gastrointestinal discomfort. However, the mechanisms underlying the cancer suppression activity of PCa in colorectal cancer (CRC) cells have yet to be clarified. The aim of this study was to investigate the anticancer effects of PCa, specifically the induction of apoptosis in CRC cells. The growth inhibition curve of CRC cells following exposure to PCa was detected by an MTT assay. Moreover, PCa combined with 5-FU revealed a synergic effect of decreased cell viability. PCa inhibited cell proliferation and induced cell cycle arrest at the G/Gphase and cell apoptosis through regulation of associated protein expression. An in vivo study showed that PCa suppressed the growth of CRC via induction of cell apoptosis with no significant change in body weight or organ histology. Our results demonstrated that PCa inhibits the growth of CRC cells and induces apoptosis in vitro and in vivo, which suggests the potential applicability of PCa as an anticancer agent.… Read more

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