Healers & Therapists News

Healers & Therapists News from June Meagher of AAMARHealing brings you the latest news from sources such as the BBC Health pages as well as the Green Med Info pages and Science Daily, we will be adding more news feeds shortly. Join the conversations on our LinkedIn group which has over 18,000 healers and therapists from around the globe and discover even more news and tips. If you have any news you would like to add to our website, please contact me and I can add it to our blog.

 

    • BBC News - Health
    • GreenMedInfo
    • Latest Science News -- ScienceDaily

    ONS estimates that one-in-350 people in the UK currently have coronavirus Read more

    The Home Office says it will benefit 14,000 people, but unions ask why care workers are not included. Read more

    Using the Body Mass Index to measure health inspires stigma and should be scrapped, MPs say. Read more

    The 57-year-old was diagnosed with a "really rapid, really aggressive" bladder cancer last year. Read more

    The drop in England and Wales comes amid efforts to reassure the public about vaccine safety. Read more

    We take a look at why these unusual clots happen and when they occur. Read more

    A decline in cases has stalled but deaths have not followed the same pattern, scientists say. Read more

    Susan Lowe is among the carers who struggled to get pain relief for a loved one during the pandemic. Read more

    A review finds a "plausible" link to rare blood clots, but says the jab remains beneficial for most. Read more

    Researchers looked at how likely 600,000 patients were to develop one of 14 common brain conditions. Read more

    The vaccine is the third to be used in the UK, with England's rollout due "in the next few days". Read more

    The UK's regulator is to investigate the Oxford-AstraZeneca jab over a possible link with blood clots. Read more

    It came as the Scottish government confirmed that under-30s will be offered an alternative to the AstraZeneca jab. Read more

    Experts warn new variants coming from Brazil could undermine global efforts to control the pandemic. Read more

    Benefits of the AstraZeneca jab outweigh the risks, the UK regulator says, amid blood clots concern Read more

    Introducing Covid status certificates risks creating a "two-tier Britain", critics say. Read more

    The 26 clinics, providing treatment for 6,000 new parents, will open by April 2022, NHS England says. Read more

    Thousands of NHS staff, from dentists to physiotherapists, have been redeployed during the pandemic. Read more

    A former health coach is blogging about her experience with the condition to help others get diagnosed. Read more

    AstraZeneca has become a political football in a European blame game over its Covid vaccine. Read more

    A conversation on a bus led to the setting up of the Recovery trial, leading to treatments for Covid. Read more

    A report by MPs and peers is calling on ministers to reconnect communities and combat loneliness after coronavirus. Read more

    Six other countries were worse affected during the second wave of the pandemic, according to ONS figures. Read more

    Regulators give reassurance and advice on rare blood clot symptoms, such as headache lasting days. Read more

    It may be a remote island, but there is a reason why Iceland is proud of its success in tackling the pandemic. Read more

    A year into the pandemic, we look at countries that have had some success in tackling the virus. Read more

    More cases are being found in the UK, including a variant first seen in Brazil. Read more

    Busting myths and explaining the facts around vaccines. Read more

    Under-30s will be not be offered the AstraZeneca vaccine, after concerns over rare blood clots. Read more

    The rules on how many people can meet outdoors are changing, as lockdown is eased. Read more

    As the UK cautiously unlocks, experts will review the evidence on when and where masks are needed. Read more

    Shielding in England is ending on 31 March. Read more

    Why experts are concerned about the emergence of this particular new version of coronavirus. Read more

    Explore the data on coronavirus in the UK and find out how many cases there are in your area. Read more

    What is it like to have the coronavirus, how will it affect you and how is it treated? Read more

    Some people across the UK have been able to form "support bubbles" or "extended households". Read more

    What are the tests for coronavirus, who are they for, and how do they work? Read more

    A new cough, fever and change in smell or taste are the key symptoms that mean you may have coronavirus. Read more

    Use our tool to check the meaning of key words and phrases associated with the Covid-19 outbreak. Read more

    While most people will have mild symptoms and recover quickly, some are more prone to getting sick. Read more

    - greenmedinfo

    PMID:  Mymensingh Med J. 2021 Apr ;30(2):301-306. PMID: 33830106 Abstract Title:  Relation between Serum Magnesium Level and Migraine. Abstract:  Migraine is one of the most disabling types of headache. It affects 4-6% of men and 13-18% of women; more than 80% of them are under 30 years. Many theories to explain mechanism of migraine are present; role of serum magnesium is one of them. This Cross-sectional analytical study was designed to see serum magnesium level status of migraine patients in Bangladesh and to find out any relation. The study was carried out in Outpatient Department of Neurology of Mymensingh Medical College Hospital, Mymensingh, Bangladesh from July 2017 to September 2018. Seventy (70) patients between 18-60 years of both sexes with headache fulfilling the criteria for migraine were enrolled as migraine group. Patients with headache who did not fulfill the criteria of migraine enrolled as non migraine group. Patients were included in both groups after exclusion of structural lesions, magnesium containing drug intake, pregnancy, menstruation, alcoholism, renal or GIT problems. Serum magnesium levels were studied in both groups and compared with each other. All related factors such as age, sex, family history of migraine, occupation were assessed. Fifty one (51) of… Read more

    - greenmedinfo

    PMID:  Int J Environ Res Public Health. 2021 Mar 1 ;18(5). Epub 2021 Mar 1. PMID: 33804513 Abstract Title:  Microplastics: A Threat for Male Fertility. Abstract:  Much of the planet is swimming in discarded plastic, which is harming animal and possibly human health. Once at sea, sunlight, wind, and wave action break down plastic waste into small particles: the microplastics (MPs). Currently, particular attention has been drawn to their effects on aquatic environments but the health risks, especially in mammals, are poorly known. These non-biodegradable materials can act as a vector for environmental pollutants, can be ingested by humans in food and water, and can enter and accumulate in human tissues with a possible risk for heath. Recent studies revealed the deleterious effects of MPs exposure in male reproduction and sperm quality, making them a potential hazard to reproductive success. This manuscript summarizes the main changes in sperm quality along the lifespan and the upcoming studies on the effects of MPs in male fertility in mammals. read more Read more

    - greenmedinfo

    PMID:  Int J Mol Sci. 2020 Aug 6 ;21(16). Epub 2020 Aug 6. PMID: 32781724 Abstract Title:  Anti-Obesity Effects of Polyphenol Intake: Current Status and Future Possibilities. Abstract:  The prevalence of obesity has steadily increased worldwide over the past three decades. The conventional approaches to prevent or treat this syndrome and its associated complications include a balanced diet, an increase energy expenditure, and lifestyle modification. Multiple pharmacological and non-pharmacological interventions have been developed with the aim of improving obesity complications. Recently, the use of functional foods and their bioactive components is considered a new approach in the prevention and management of this disease. Due to their biological properties, polyphenols may be considered as nutraceuticals and food supplement recommended for different syndromes. Polyphenols are a class of naturally-occurring phytochemicals, some of which have been shown to modulate physiological and molecular pathways involved in energy metabolism. Polyphenols could act in the stimulation ofβ-oxidation, adipocyte differentiation inhibition, counteract oxidative stress, etc. In this narrative review, we considered the association between polyphenols (resveratrol, quercetin, curcumin, and some polyphenolic extracts) and obesity, focusing on human trials. The health effects of polyphenols depend on the amount consumed and their bioavailability. Some results are contrasting, probably due… Read more

    - greenmedinfo

    PMID:  Int J Mol Sci. 2017 Nov 10 ;18(11). Epub 2017 Nov 10. PMID: 29125587 Abstract Title:  Polyphenol-Rich Lentils and Their Health Promoting Effects. Abstract:  Polyphenols are a group of plant metabolites with potent antioxidant properties, which protect against various chronic diseases induced by oxidative stress. Evidence showed that dietary polyphenols have emerged as one of the prominent scientific interests due to their role in the prevention of degenerative diseases in humans. Possible health beneficial effects of polyphenols are measured based on the human consumption and their bioavailability. Lentil (; Family: Fabaceae) is a great source of polyphenol compounds with various health-promoting properties. Polyphenol-rich lentils have a potential effect on human health, possessing properties such as antioxidant, antidiabetic, anti-obesity, anti-hyperlipidemic, anti-inflammatory and anticancer. Based on the explorative study, the current comprehensive review aims to give up-to-date information on nutritive compositions, bioactive compounds and the health-promoting effect of polyphenol-rich lentils, which explores their therapeutic values for future clinical studies. All data of in vitroin vivo and clinical studies of lentils and their impact on human health were collected from a library database and electronic search (Science Direct, PubMed and Google Scholar). Health-promoting information was gathered and orchestrated in the suitable place… Read more

    - greenmedinfo

    PMID:  J Tradit Complement Med. 2021 Mar ;11(2):130-136. Epub 2020 Feb 28. PMID: 33728273 Abstract Title:  Portuguese honeys as antimicrobial agents againstspecies. Abstract:  Background and aim: Honey has been recognized worldwide for its antioxidant, anti-tumor, anti-inflammatory and antimicrobial properties. Among them, the antifungal properties associated to honey make it an attractive alternative treatment for-associated infections, particularly for topical application to the mucous membranes and skin. In this sense, the main purpose of this work was to evaluate physicochemical properties of five Portuguese honeys and Manuka honey (an Australian honey with well recognized medical proprieties, used as control) and to evaluate the antifungal activity inspecies planktonic and biofilm assays.Experimental procedure: Pollen analysis, pH determination, color, concentration of protein and methylglyoxal, conductivity, total phenolics and flavonoids, hydrogen peroxide concentration, and characterization by differential scanning calorimetry in honey samples were determined. Additionally, the effect of honeys on planktonic growth ofwas initially evaluated by determination of the minimum inhibitory concentrations. Then, the same effect of those honeys was evaluated in biofilms, by Colony Forming Units enumeration.Results and conclusion: It has been shown that Portuguese heather () honey presented the most similar physicochemical properties to manuka honey (specially phenolic and flavonoids contents). The five Portuguese… Read more

    - greenmedinfo

    PMID:  Int J Biol Macromol. 2021 Mar 24 ;181:180-192. Epub 2021 Mar 24. PMID: 33771548 Abstract Title:  Fucoidan induces ROS-dependent epigenetic modulation in cervical cancer HeLa cell. Abstract:  Fucoidan is a sulfated polysaccharide obtained from marine algae and known for various pharmacological activities. In this study, we investigated the effect of Fucoidan on cell viability, redox balance, cytoskeletal component F-actin, HDAC inhibition, autophagy, and senescence phenomenon in human cervical cancer HeLa cell line in comparison to positive control suberoylanilide hydroxamic acid by flow cytometry, fluorescence microscopy, and western blotting. Our observations revealed that Fucoidan exposure induces cytotoxicity in HeLa cells via ROS and mitochondrial superoxide generation and loss of ATP. Colorimetrical studies suggested that Fucoidan impairs the function of HDAC expression. Fucoidan treatment also contributes to the change in the granularity of cells, senescence-associated heterochromatin foci formation that leads to senescence in HeLa cells. Moreover, we visualize that Fucoidan exhibits autophagosomes formation with monodansylcadaverine, and flow cytometry analysis by acridine orange further substantiates that Fucoidan triggers autophagy in HeLa cells. Additionally, the changes in the expression of proteins p21, p16, BECN1, and HDAC1 were seen as markers of senescence, autophagy, and HDAC inhibition by FACS and immunoblotting. Molecular docking study… Read more

    - greenmedinfo

    PMID:  Comp Biochem Physiol C Toxicol Pharmacol. 2021 Mar 24 ;245:109035. Epub 2021 Mar 24. PMID: 33774206 Abstract Title:  Fucoidan ameliorates acute and sub-chronic in vivo toxicity of the fungicide cholorothalonil in Oreochromis niloticus (Nile tilapia). Abstract:  Fucoidans are sulfated glycans from marine algae that have both anti-cancer and anti-microbial properties. Chlorothalonil is a fungicide and insecticide commonly used in agriculture. Chlorothalonil is relatively toxic to fish and can potentially affect the aquaculture practices. In this study, we determined whether fucoidan administration would offer any protection from acute and subchronic toxicity of chlorothalonil on Nile tilapia. First, we tested the effect of chlorothalonil (20 to 140 μg/L, water-applied) on Nile tilapia in an acute exposure (six days). Survival analysis was performed, together with assessment of histopathology, oxidative stress (i.e., antioxidant status, hydrogen peroxide levels, malondialdehyde and nitric oxide levels) and immunohistochemistry to measure indicators of hepatic damage (i.e., caspase 3, p53, mini-chromosome maintenance proteins (MCM), and glutathione peroxidase). Chlorothalonil induced mild to severe histopathological alterations that were dose-dependent in various tissues of Nile tilapia. Chlorothalonil also induced oxidative stress as indicated by elevated biochemical markers. The highest recorded mortalities were associated with p53 expression. Additional feeding experiments were conducted with fucoidan… Read more

    - greenmedinfo

    PMID:  Viruses. 2021 Mar 11 ;13(3). Epub 2021 Mar 11. PMID: 33799811 Abstract Title:  Fucoidan But Not 2'-Fucosyllactose Inhibits Human Norovirus Replication in Zebrafish Larvae. Abstract:  Human noroviruses (hNoVs) cause heavy disease burden worldwide and there is no clinically approved vaccination or antiviral hitherto. In this study, with the use of a zebrafish larva in vivo platform, we investigated the anti-hNoV potentials of fucoidan (from brown algae) and 2'-Fucosyllactose (2'-FL). As a result, although both fucoidan and 2'-FL were able to block hNoV GII.4 virus-like particle (VLPs) from binding to type A saliva as expected, only fucoidan, but not 2'-FL, was able to inhibit the replication of hNoV GII.P16-GII.4 in zebrafish larvae, indicating the possible needs of higher molecular weights for fucosylated carbohydrates to exert anti-hNoV effect. read more Read more

    - greenmedinfo

    PMID:  Molecules. 2021 Mar 30 ;26(7). Epub 2021 Mar 30. PMID: 33808318 Abstract Title:  The Ameliorative Effects of Fucoidan in Thioacetaide-Induced Liver Injury in Mice. Abstract:  Liver disorders have been recognized as one major health concern. Fucoidan, a sulfated polysaccharide extracted from the brown seaweed Fucus serratus, has previously been reported as an anti-inflammatory and antioxidant. However, the discovery and validation of its hepatoprotective properties and elucidation of its mechanisms of action are still unknown. The objective of the current study was to investigate the effect and possible modes of action of a treatment of fucoidan against thioacetamide (TAA)-induced liver injury in male C57BL/6 mice by serum biochemical and histological analyses. The mouse model for liver damage was developed by the administration of TAA thrice a week for six weeks. The mice with TAA-induced liver injury were orally administered fucoidan once a day for 42 days. The treated mice showed significantly higher body weights; food intakes; hepatic antioxidative enzymes (catalase, glutathione peroxidase (GPx), and superoxide dismutase (SOD)); and a lower serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and C-reactive protein (CRP) levels. Additionally, a reduced hepatic IL-6 level and a decreased expression of inflammatory-related… Read more

    - greenmedinfo

    PMID:  Mar Drugs. 2021 Mar 12 ;19(3). Epub 2021 Mar 12. PMID: 33809062 Abstract Title:  Fucoidan and Fucoxanthin Attenuate Hepatic Steatosis and Inflammation of NAFLD through Modulation of Leptin/Adiponectin Axis. Abstract:  Non-alcoholic fatty liver disease (NAFLD) is the emerging cause of chronic liver disease globally and lack of approved therapies. Here, we investigated the feasibility of combinatorial effects of low molecular weight fucoidan and high stability fucoxanthin (LMF-HSFx) as a therapeutic approach against NAFLD. We evaluated the inhibitory effects of LMF-HSFx or placebo in 42 NAFLD patients for 24 weeks and related mechanism in high fat diet (HFD) mice model and HepaRGcell line. We found that LMF-HSFx reduces the relative values of alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglyceride, fasting blood glucose and hemoglobin A1c in NAFLD patients. For lipid metabolism, LMF-HSFx reduces the scores of controlled attenuation parameter (CAP) and increases adiponectin and leptin expression. Interestingly, it reduces liver fibrosis in NAFLD patients, either. The proinflammatory cytokines interleukin (IL)-6 and interferon-γ are reduced in LMF-HSFx group. In HFD mice, LMF-HSFx attenuates hepatic lipotoxicity and modulates adipogenesis. Additionally, LMF-HSFx modulates SIRI-PGC-1 pathway in HepaRG cells under palmitic acid-induced lipotoxicity environment. Here, we describe that LMF-HSFx ameliorated hepatic steatosis,inflammation, fibrosis and… Read more

    - DianeFulton

    Pomegranate, with its characteristic red arils, is small but mighty when it comes to substantial benefits to your health as a superfood Read more

    - greenmedinfo

    PMID:  Front Endocrinol (Lausanne). 2021 ;12:645519. Epub 2021 Mar 11. PMID: 33776939 Abstract Title:  Bisphenol A and Bisphenol S Induce Endocrine and Chromosomal Alterations in Brown Trout. Abstract:  Bisphenol A is a widely used compound found in large amount of consumer products. As concerns have been raised about its toxicological and public health effect, the use of alternatives to bisphenol A are now increasing. Bisphenol S is one of the analogues being used as a replacement for bisphenol A despite the fact that little is known about the effects of bisphenol S on living organisms. In this study, we investigated the potential endocrine and genotoxic effects of bisphenol A and bisphenol S in juvenile brown trout (). The fish were exposed to the compounds for either 2 weeks or 8 weekssustained-release cholesterol implants containing doses of 2 mg/kg fish or 20 mg/kg fish of the substances. The effects on the thyroid hormone levels and the estrogenic disrupting marker vitellogenin were evaluated, along with the genotoxic markers micronucleated cells and erythrocyte nuclear abnormalities. An increase in plasma vitellogenin was observed in fish exposed to the high dose of bisphenol A for 2 weeks. At this experimental time the level of the… Read more

    - greenmedinfo

    PMID:  Environ Res. 2021 Mar 30 ;197:111062. Epub 2021 Mar 30. PMID: 33798517 Abstract Title:  Metabolic pathways, alterations in miRNAs expression and effects of genetic polymorphisms of bisphenol a analogues: A systematic review. Abstract:  Bisphenol A (BPA) is one of the most common endocrine disruptors found in the environment and its harmful health effects in humans and wildlife have been extensively reported One of the main aims of this review was to examine the metabolic pathways of BPA and BPA substitutes and the endocrine disrupting properties of their metabolites. According to the available literature, phase I and phase II metabolic reactions play an important role in the detoxification process of bisphenols (BPs), but their metabolism can also lead to the formation of highly reactive metabolites. The second part of this work addresses the associations between exposure to BPA and its analogues with the alterations in miRNAs expression and the effects of single nucleotide polymorphisms (SNPs). Available scientific evidence shows that BPs can dysregulate the expression of several miRNAs, and in turn, these miRNAs could be considered as epigenetic biomarkers to prevent the development of a variety of BP-mediated diseases. Interestingly, genetic polymorphisms are able to modify the relationship of BPA… Read more

    - DianeFulton
    Pomegranate: Evidence-Based Benefits of This Antioxidant Superstar

    This article is copyrighted by GreenMedInfo LLC, 2021Visit our Re-post guidelines Pomegranate, with its characteristic red arils, is small but mighty when it comes to substantial benefits to your health as a superfoodread more Read more

    - greenmedinfo

    PMID:  Ecotoxicol Environ Saf. 2021 Mar 30 ;216:112158. Epub 2021 Mar 30. PMID: 33798865 Abstract Title:  Toxic effect of fluorene-9-bisphenol to green algae Chlorella vulgaris and its metabolic fate. Abstract:  Fluorene-9-bisphenol (BHPF), a bisphenol A (BPA) alternative, has recently attracted attention due to its wide use and potential toxicity. However, the toxic effects and fate of BHPF in freshwater algae remains to be elucidated. In this study, the impact of BHPF on Chlorella vulgaris was explored and the removal and bioaccumulation of BHPF by Chlorella vulgaris were investigated. Results showed that C. vulgaris was sensitive to BHPF at the concentration of>1 mg L, and lipid peroxidation was significantly increased under the exposure of>0.1 mg BHPF L. An oxidative stress was caused by BHPF, as the activities of superoxide dismutase (SOD) were significantly decreased in algal cells by>0.5 mg BHPF L. The removal rate of BHPF was significantly enhanced by the addition of algae. In addition, the increasing accumulation of BHPF in algae at concentrations ranging from 0.5 to 5 mg Lwas observed and may contribute for the increased toxicity of BHPF to C. vulgaris. Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) results demonstrated that three metabolites of BHPF were identified in algal cells, which may pose an… Read more

    - greenmedinfo

    PMID:  Biology (Basel). 2021 Mar 3 ;10(3). Epub 2021 Mar 3. PMID: 33802301 Abstract Title:  Bisphenol A and S in the Urine of Newborns: Plastic for Non-Food Use Still without Rules. Abstract:  The aim of the present study was to assess the effects of bisphenol (BP) exposure on pregnancy and neonatal life. We have (a) determined BP (BPA and BPS) concentration levels in a group of newborns and their mothers; (b) identified factors, habits, and devices possibly responsible for BP uptake; and (c) determined the effect of BP exposure. No significant correlations were detected between maternal and neonatal BP concentration levels. In newborns, positive correlations between pacifier use and BPS total (= 0.04) and free BPS (= 0.03) concentrations were detected. A significant correlation was also found between oral glucose administration and concentration levels of free BPA (read more Read more

    - greenmedinfo

    PMID:  Reprod Fertil Dev. 2021 Mar ;33(5):319-327. PMID: 33632378 Abstract Title:  Di-n-butyl phthalate diminishes testicular steroidogenesis by blocking the hypothalamic-pituitary-testicular axis: relationship with germ cell apoptosis in Japanese quail. Abstract:  Although di-n-butyl phthalate (DBP) induces germ cell apoptosis, the underlying mechanism is not yet clear in quail. In this study, prepubertal quails were given a single dose of 500mg kg-1 DBP by gavage and were then killed 3, 6 and 24h after treatment. There was a significant reduction in intratesticular testosterone (ITT) concentrations and testicular steroidogenic enzyme mRNA expression and a significant increase in germ cell apoptosis in DBP-treated compared with control quails at all time points. Maximum apoptosis was detected 6h after treatment and the maximum reduction in testosterone concentrations was at 3h. To investigate whether DBP suppressed testicular steroidogenesis by affecting the hypothalamic-pituitary-testicular axis, we analysed pituitary LH subunitβ (Lhb) mRNA expression and serum LH concentrations. At all time points, pituitary Lhb expression and serum LH concentrations were significantly decreased following DBP treatment. The present observations suggest the possibility that DBP blocked LH secretion from the hypothalamus and/or pituitary,thereby decreasing LH stimulation of Leydig cells and reducing ITT concentrations. DBP-induced decreases in ITT concentrations may cause changes to… Read more

    - greenmedinfo

    PMID:  Front Immunol. 2021 ;12:599345. Epub 2021 Feb 15. PMID: 33659001 Abstract Title:  Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses. Abstract:  Exposure to environmental hormones such as di(2-ethylhexyl) phthalate (DEHP) has become a critical human health issue globally. This study aimed to investigate the correlations between DEHP/mono-(2-ethylhexyl) phthalate (MEHP) levels and macrophage-associated immune responses and clinical manifestations in dengue virus (DV)-infected patients. Among 89 DV-infected patients, those with DV infection-related gastrointestinal (GI) bleeding (n = 13, 15% of patients) had significantly higher DEHP exposure than those without GI bleeding (n = 76, 85% of patients), which were 114.2 ng/ml versus 52.5 ng/mlΣDEHP in urine; p = 0.023). In anstudy using cultured human monocyte-derived macrophages (MDMs) to investigate the effects of MEHP, treatment increased IL-1β and TNF-α release but decreased IL-23 release, with negative correlations observed between urine ΣDEHP and serum IL-23 levels in patients. MEHP-treated MDMs had lower antiviral Th17 response induction activity in mixed T-cell response tests. Thedata showed that MEHP increased DV viral load and decreased IL-23 release dose-dependently, and adding IL-23 to MEHP-exposed MDMs significantly reduced the DV viral load. MEHP also suppressed IL-23 expressionthe peroxisome proliferator-activated receptor-gamma (PPAR-γ) pathway. Further, the PPAR-γ… Read more

    - greenmedinfo

    PMID:  Environ Toxicol. 2021 Mar 4. Epub 2021 Mar 4. PMID: 33665894 Abstract Title:  Di-(2-ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice. Abstract:  Di-(2-ethylhexyl) phthalate (DEHP) is one of the most commonly used plasticizers, and it is widely applied in various plastic products. DEHP is an endocrine-disrupting chemical (EDC) that has been shown to disrupt the function of reproductive system in females. Although many studies have shown that DEHP potentially causes female reproductive toxicity, including depletion of the primordial follicle and decreased sex hormone production, the specific mechanisms by which DEHP affects female reproduction remain unknown. In recent years, research focused on the intestinal flora has provided an idea to eliminate our confusion, and gut bacterial dysbiosis may contribute to female reproductive toxicity. In the present study, the feces of DEHP-exposed mice were collected and analyzed using 16S rRNA amplicon sequencing and untargeted global metabolite profiling of metabolomics. DEHP obviously causes reproductive toxicity, including the ovarian organ coefficient, estradiol level, histological features of the ovary and estrus. Furthermore, DEHP exposure alters the structure of the intestinal microbiota community and fecal metabolite profile in mice, suggesting that the reproductive… Read more

    - greenmedinfo

    PMID:  Pharmacol Res. 2021 Mar 4 ;167:105536. Epub 2021 Mar 4. PMID: 33677105 Abstract Title:  Reproductive toxic potential of phthalate compounds - State of art review. Abstract:  Phthalates are pervasive compounds, and due to the ubiquitous usage of phthalates, humans or even children are widely exposed to them. Since phthalates are not chemically bound to the plastic matrix, they can easily leach out to contaminate the peripheral environment. Various animal and human studies have raised vital health concern including developmental and reproductive toxicity of phthalate exposure. The present review is based upon the available literature on phthalates with respect to their reproductive toxic potential. Common reproductive effects such as declined fertility, reduced testis weight, variations in accessory sex organs and several female reproductive disorders appeared to be largely associated with the transitional phthalates. Among the higher molecular weight phthalates (≥ C7), di-isononyl phthalate (DINP) produces some minor effects on development of male reproductive tract and among low molecular weight phthalates (≤C3), di-methyl (DMP) and di-isobutyl (DIBP) phthalate produce some adverse effects on male reproductive system. Whereas transitional phthalates such as di-butyl phthalate, benzyl butyl phthalate, and di-(2-ethylhexyl) phthalate have shown adverse effects on female reproductive system. Owing to these, non-toxic… Read more

    - greenmedinfo

    PMID:  Environ Res. 2021 Mar 7 ;197:110981. Epub 2021 Mar 7. PMID: 33691158 Abstract Title:  Early life exposure to phthalates and the development of childhood asthma among Canadian children. Abstract:  BACKGROUND: Studies have demonstrated an association between phthalate exposure and childhood asthma, although results have been inconsistent. No epidemiological studies have examined exposure during the first year of life.OBJECTIVE: To investigate the association between phthalate exposures in the home environment during the first year of life, and subsequent development of childhood asthma and related symptoms.METHODS: This study used a case-cohort design including 436 randomly selected children and all additional cases of asthma at 5 years (n = 129) and recurrent wheeze between 2 and 5 years (n = 332) within the CHILD Cohort Study, a general population Canadian birth cohort of 3455 children. Phthalate exposure was assessed using house dust samples collected during a standardized home visit when children were 3-4 months of age. All children were assessed by specialist clinicians for asthma and allergy at 1, 3 and 5 years. Logistic regression was used to assess the association between exposure to five phthalates and asthma diagnosis at 5 years, and recurrent wheeze between 2 and 5 years, with further stratification by wheeze subtypes… Read more

    - greenmedinfo

    PMID:  Neurotoxicology. 2021 Mar 8 ;84:84-95. Epub 2021 Mar 8. PMID: 33705789 Abstract Title:  Associations of prenatal exposure to phthalates with measures of cognition in 7.5-month-old infants. Abstract:  BACKGROUND: Phthalates are endocrine disrupting chemicals that have been associated with adverse neurobehavior, but little is known about their influence on infant cognition.METHODS: A visual recognition memory task was used to assess cognition in 244 7-8-month-old infants (121 females; 123 males) from a prospective cohort study. Phthalate metabolites were quantified in maternal urines pooled from across pregnancy. The task included familiarization trials (infant shown 2 identical faces) and test trials (infant shown the now familiar face paired with a novel one). Half of the infants saw one set of faces as familiar (set 1) and half saw the other set as familiar (set 2). During familiarization trials, average run duration (time looking at stimuli before looking away, measure of processing speed), and time to familiarization (time to reach 20 s looking at the stimuli, measure of attention) were assessed. During test trials, novelty preference (proportion of time looking at the novel face, measure of recognition memory) was assessed. Multivariable generalized linear models were used to assess associations of monoethyl phthalate (MEP), sum… Read more

    - greenmedinfo

    PMID:  Toxicology. 2021 Mar 9 ;454:152746. Epub 2021 Mar 9. PMID: 33711355 Abstract Title:  Effects of phthalates on the functions and fertility of mouse spermatozoa. Abstract:  Phthalates are common environmental pollutants that are presumed to negatively impact male fertility including animals and humans. Particularly, these potential xenoestrogens may alter male fertility by binding to specific sperm receptors. Although several studies have characterized the toxic effects of single phthalates, epidemiological studies indicate that humans are typically exposed to phthalate mixtures. Here, we tested an environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate. Specifically, the effects of short-term exposure (90 min) to various concentrations (1, 10, 100, and 500 μg/mL) of this phthalate mixture on several important sperm processes, oocyte fertilization, and embryo production were assessed. All phthalate concentrations significantly decreased sperm motility and hyperactivity by compromising the sperm's ability to generate ATP. Additionally, short-term phthalate exposure (>10 μg/mL) also induced abnormal capacitation and the acrosome reaction by upregulating protein tyrosine phosphorylation via a protein kinase-A-dependent pathway. Furthermore, phthalate exposure (particularly at doses exceeding 10 μg/mL) significantly affected fertilization and early embryonic development. Together, our findings… Read more

    - greenmedinfo

    PMID:  Hum Cell. 2021 Mar 15. Epub 2021 Mar 15. PMID: 33721218 Abstract Title:  Diethylhexyl phthalate (DEHP) regulates the proliferation and chemosensitivity of esophageal squamous cell carcinoma cells via regulation of PTEN. Abstract:  As one of the most prevalent and deadly cancers worldwide, esophageal squamous cell carcinoma (ESCC) can be directly exposed to endocrine-disrupting chemical (EDC). As a potential EDC, diethylhexyl phthalate (DEHP) can trigger the development of various cancers, while the potential effect of DEHP on the ESCC progression was not clear. Our present study revealed that DEHP can trigger the proliferation of ESCC cells and decrease the cisplatin (CDDP) and fluorouracil (5-FU) sensitivity. Mechanistical studies indicated that DEHP can decrease the transcription of PTEN, a well-characterized tumor suppressor, in ESCC cells. Over expression of PTEN can reverse DEHP-regulated ESCC cell proliferation and chemosensitivity. Further, DEHP can increase the expression of HES-1, which can bind with the promoter of PTEN to inhibit its transcription. Collectively, DEHP can increase proliferation while decrease chemosensitivity of ESCC cells via regulation of HES-1/PTEN axis. Further, daily expression of DEHP may be a potent risk factor for ESCC development. read more Read more

    - greenmedinfo

    PMID:  Front Public Health. 2021 ;9:620769. Epub 2021 Feb 26. PMID: 33718320 Abstract Title:  Exposure to Phenols, Phthalates, and Parabens and Development of Metabolic Syndrome Among Mexican Women in Midlife. Abstract:  Evidence suggests exposure to endocrine-disrupting chemicals (EDCs) can influence Metabolic Syndrome (MetS) risk in adults, but it is unclear if EDCs impact women during midlife. We examined if EDCs measured in adult women were predictive of MetS and its components 9 years later.We measured urinary phthalate metabolites, phenols, and parabens collected in 2008 among 73 females from the ELEMENT study. MetS and its components (Abdominal Obesity, Hypertriglyceridemia, Cholesterolemia, Hypertension, and Hyperglycemia) were assessed in 2017. We regressed log-transformed EDC concentrations on MetS and MetS components using logistic regression, adjusting for age and physical activity.At follow-up, the mean (SD) age was 46.6 (6.3) years; the prevalence of MetS was 34.3%. Sum of dibutyl phthalate metabolites (ΣDBP), monobenzyl phthalate (MBzP), and monoethyl phthalate (MEP) were associated with an increased odds of hypertriglyceridemia. 2,5-dichlorophenol (2,5 DCP) and 2,4-dichlorophenol (2,4 DCP) were associated with increased odds of hypertriglyceridemia. The odds of hypertension were 4.18 (95% CI: 0.98, 17.7,read more Read more

    - greenmedinfo

    PMID:  Hum Exp Toxicol. 2021 Mar 17:9603271211001124. Epub 2021 Mar 17. PMID: 33729022 Abstract Title:  Curcumin decreases dibutyl phthalate-induced renal dysfunction in Kunming mice via inhibiting oxidative stress and apoptosis. Abstract:  Curcumin (Cur) has been used extensively in dietary supplement with antioxidant and anti-apoptotic properties. Although dibutyl phthalate (DBP) has adverse effects on the kidney, any association between DBP exposure and the role of Cur is unclear. We tested the hypothesis that exposure to DBP has adverse consequences on renal dysfunction in mice and the potential protective role of Cur in decreasing DBP-induced renal dysfunction via inhibiting oxidative stress and apoptosis. Kidney function, oxidative stress biomarkers, and apoptosis factors as well as Bcl-2 and Bax were investigated. The results showed a marked increase of renal dysfunction, oxidative stress and apoptosis level after DBP exposure compared to the control. While administration of Cur to DBP-treated mice may reduce these adverse biochemical changes compared with DBP-alone group. Overall, these results suggest that oxidative stress and apoptosis are involved in DBP-induced renal disorder, whereas Cur plays a protective role in inhibiting these two pathways. read more Read more

    - greenmedinfo

    PMID:  Chemosphere. 2021 May ;271:129740. Epub 2021 Jan 22. PMID: 33736212 Abstract Title:  Exposure to phthalates DEHP and DINP May lead to oxidative damage and lipidomic disruptions in mouse kidney. Abstract:  Di(2-ethylhexyl) phthalate (DEHP) has been well acknowledged for its endocrine disruption and associated metabolic diseases, leading to the search for safer industrial alternatives including di-isononyl phthalate (DINP). However, safety data for the latter chemical has been relatively scarce particularly regarding potential damage to the kidney at low doses. Five-week-old ICR male mice were exposed to vehicle, DEHP or DINP (0.05 and 4.8 mg/kg bw) daily via gavage for 5 weeks. We observed increased levels of reactive oxygen species and malondialdehyde, decreased levels of reduced glutathione, in the kidney at higher dose for both chemicals suggestive of oxidative damage. Elevated levels of inflammatory cytokines tumor necrosis factor-α and interleukin-6 of the kidney further suggested inflammatory status as a result of phthalate exposure in both high dose groups. Targeted lipidomics demonstrated greatest changes in the kidney induced by high dose of DEHP, although DINP also induced significant changes in phospholipids diacylglycerides that are associated with lipid accumulation in glomerular podocytes and inflammatory responses. Our data suggest that oxidative stress may be involved… Read more

    - greenmedinfo

    PMID:  J Clin Endocrinol Metab. 2021 Apr 1. Epub 2021 Apr 1. PMID: 33792735 Abstract Title:  Prenatal exposure to bisphenols and phthalates and postpartum depression: The role of neurosteroid hormone disruption. Abstract:  CONTEXT: Postpartum depression (PPD) is a serious psychiatric disorder. While causes remain poorly understood, perinatal sex hormone fluctuations are an important factor, and allopregnanolone in particular has emerged as a key determinant. While synthetic environmental chemicals such as bisphenols and phthalates are known to affect sex hormones, no studies have measured allopregnanolone and the consequences of these hormonal changes on PPD have not been interrogated.OBJECTIVE: To investigate associations of repeated measures of urinary bisphenols and phthalates in early- and mid-pregnancy with serum pregnenolone, progesterone, allopregnanolone, and pregnanolone concentrations in mid-pregnancy and PPD symptoms at four months postpartum.DESIGN, SETTING, PARTICIPANTS, AND INTERVENTION: Prospective cohort study of 139 pregnant women recruited between 2016-18. Bisphenols and phthalates were measured in early- and mid-pregnancy urine samples. Serum sex steroid hormone concentrations were measured in mid-pregnancy. PPD was assessed at 4 months postpartum using the Edinburgh Postnatal Depression Scale (EPDS). Multiple informant models were fit using generalized estimating equations.MAIN OUTCOME MEASURES: Serum levels of allopregnanolone, progesterone, pregnanolone, and pregnenolone were examined as log-transformed… Read more

    - greenmedinfo

    PMID:  Breast Cancer Res. 2021 Apr 6 ;23(1):44. Epub 2021 Apr 6. PMID: 33823904 Abstract Title:  Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study. Abstract:  BACKGROUND: The epidemiologic evidence from observational studies on breast cancer risk and phthalates, endocrine disrupting chemicals, has been inconsistent. In the only previous study based on pre-diagnostic urinary phthalates and risk of breast cancer, results were null in mostly white women.METHODS: We examined the association between pre-diagnostic urinary phthalates and breast cancer in a nested case-control study within the Multiethnic Cohort (MEC) study, presenting the first data from five major racial/ethnic groups in the USA. We measured 10 phthalate metabolites and phthalic acid, using a sensitive liquid chromatography mass spectrometry assay on 1032 women with breast cancer (48 African Americans, 77 Latinos, 155 Native Hawaiians, 478 Japanese Americans, and 274 Whites) and 1030 matched controls. Conditional logistic regression was used to examine risk with individual metabolites and ratios of primary (MEHP, mono-2-ethylhexyl-phthalate) to secondary (MEHHP, mono(2-ethyl-5-hydroxyhexyl); MEOHP, mono(2-ethyl-5-oxohexy)) metabolites of di-2-ethylhexyl phthalate (DEHP), a widely used plasticizer. In addition, we investigated risk associations with high (∑HMWP) and low molecular weight (∑LMWP) phthalates, as well as total phthalates which included high and… Read more

    - greenmedinfo

    PMID:  Int J Environ Res Public Health. 2021 Mar 1 ;18(5). Epub 2021 Mar 1. PMID: 33804363 Abstract Title:  The Association of Bisphenol A and Phthalates with Risk of Breast Cancer: A Meta-Analysis. Abstract:  BACKGROUND: Breast cancer is the most common cancer and the second leading cause of cancer-related death amongst American women. Endocrine-disrupting chemicals (EDCs), especially bisphenol A (BPA) and phthalates, have adverse effects on human health. However, the association of BPA and phthalates with breast cancer remains conflicting. This study aims to investigate the association of BPA and phthalates with breast cancer.METHODS: Correlative studies were identified by systematically searching three electronic databases, namely, PubMed, Web of Sciences, and Embase, up to November 2020. All data were analyzed using Stata 15.0.RESULTS: A total of nine studies, consisting of 7820 breast cancer cases and controls, were included. The urinary phthalate metabolite mono-benzyl phthalate (MBzP) and mono-2-isobutyl phthalate (MiBP) were negatively associated with breast cancer (OR = 0.73, 95% CI: 0.60-0.90; OR = 0.75, 95% CI: 0.58-0.98, respectively). However, the overall ORs for BPA, mono-ethyl phthalate (MEP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-2-ethylhexyl phthalate (MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-(3-carboxypropyl) phthalate (MCPP), and mono-butyl phthalate (MBP) were 0.85 (95% CI: 0.69-1.05), 0.96 (95% CI:… Read more

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