Healers & Therapists News

Healers & Therapists News

Healers & Therapists News from June Meagher of AAMARHealing brings you the latest news from sources such as the BBC Health pages as well as the Green Med Info pages and Science Daily, we will be adding more news feeds shortly. Join the conversations on our LinkedIn group which has over 18,000 healers and therapists from around the globe and discover even more news and tips. If you have any news you would like to add to our website, please contact me and I can add it to our blog.


    • BBC News - Health
    • GreenMedInfo
    • Latest Science News -- ScienceDaily

    The positive trial results could pave the way for vaccinating children younger than 12, if approved. Read more

    It is estimated that fortifying flour with folic acid could prevent up to 200 birth defects a year. Read more

    The study for children aged 12 to 16 is being run by researchers in Southampton. Read more

    Explore the data on coronavirus in the UK and find out how many cases there are in your area. Read more

    Gardening is being offered as an alternative for some to lifting weights and running on treadmills. Read more

    Ros Atkins looks at the ethics of Western countries rolling out Covid booster jabs while millions globally remain unvaccinated. Read more

    An online tool could help doctors identify those who would benefit from boosters or early therapy. Read more

    Antibody therapy Ronapreve, given to Donald Trump, will be given to eligible NHS patients in hospital. Read more

    A debt collection company told some women that future visas for in the UK would be refused if they did not pay. Read more

    It's the fastest-growing genetic condition in the UK but some feel the illness, which mostly affects black people, isn't taken seriously. Read more

    People with dementia sing, play instruments and dance at the music cafe, says Manchester Camerata. Read more

    The former operator of Jeesal Cawston Park says an inquiry's findings do not apply to its homes. Read more

    Tom refuses to let cancer dominate his life after being diagnosed with an inoperable brain tumour. Read more

    One in 40 people has some long-lasting symptoms, Office for National Statistics data suggests. Read more

    A series of serious ambulance delays have emerged, including one where a man died after a 40-hour wait. Read more

    There is no evidence of any impact on fertility - but research will help to counter false claims. Read more

    Hospitals in England and Wales can now start vaccinating healthcare workers with a booster dose. Read more

    How are care home staff and residents preparing to face a second autumn and winter of Covid-19? Read more

    All over-12s in the UK will be able to get at least one Covid jab. Read more

    Ivermectin is being used by some to treat Covid-19, despite the benefits being unproven. Read more

    All children aged 12-15 across the UK will be offered one dose of the Pifzer vaccine. Read more

    More than four out of five UK adults are now fully vaccinated, but daily case rates remain high. Read more

    Lockdown rules have changed across the UK, but some restrictions remain in place. Read more

    How to weigh the pros and cons of a vaccine for a disease that is rarely serious in young people. Read more

    Face coverings could become a legal requirement in England again if the NHS struggles this winter. Read more

    Millions of children around the world are being offered a Covid vaccine. Read more

    A new cough, fever and change in smell or taste are the key symptoms that mean you may have coronavirus. Read more

    Get double-jabbed to reduce this risk, advise experts who have studied different variants of the virus. Read more

    The office that oversees US spy agencies could not establish how the coronavirus pandemic began. Read more

    The NHS initiative, for people in England over the age of 40, could save thousands of lives. Read more

    Many are facing a significant rise in the money they have to pay towards the support they receive. Read more

    Everyone in England and Scotland is being encouraged to take rapid coronavirus tests regularly. Read more

    UK coronavirus cases are rising due to a variant first identified in India that spreads more easily. Read more

    Psychologists say men need to be part of a group in order to vent their feelings and emotions. Read more

    There are fears that this version of coronavirus, first identified in South Africa, is Read more

    As social-distancing and other Covid rules end in England, how can people who were shielding stay safe? Read more

    A government scientific advisor tells Newsbeat why four weeks is too soon between Covid jabs. Read more

    Busting myths and explaining the facts around vaccines. Read more

    Some people across the UK have been able to form "support bubbles" or "extended households". Read more

    Use our tool to check the meaning of key words and phrases associated with the Covid-19 outbreak. Read more

    - greenmedinfo

    PMID:  Aging (Albany NY). 2021 07 27 ;13(14):18392-18403. Epub 2021 Jul 27. PMID: 34314383 Abstract Title:  Curcumol may alleviate psoriasis-like inflammation by inhibiting keratinocyte proliferation and inflammatory gene expression via JAK1/STAT3 signaling. Abstract:  Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation and differentiation of keratinocytes. Since curcumol exhibits anti-inflammatory properties in various diseases, we investigated its anti-inflammatory potential in stimulated human keratinocytes. Our data show that curcumol significantly inhibits proliferation and induces cell cycle arrest in NHEK cells stimulated with proinflammatory cytokines (IL-1α, IL-17A, IL-22, oncostatin M, and TNF-α; mix M5). In addition, curcumol markedly ameliorates inflammatory response and promotes differentiation of M5-stimulated NHEK cells. Curcumol inhibits activity of JAK1, resulting in the inhibition of STAT3, downregulation of cyclin D2, and cell cycle arrest in stimulated NHEK cells. Together, our data show that curcumol reduces proliferation and inflammatory gene expression in stimulated keratinocytes by inhibiting the JAK1/STAT3 signaling, suggesting that it might serve as a potential therapeutic option for the treatment of psoriasis. read more Read more

    - greenmedinfo

    PMID:  Chin J Integr Med. 2021 Jul 28. Epub 2021 Jul 28. PMID: 34319504 Abstract Title:  Effect of Curcumol on NOD-Like Receptor Thermoprotein Domain 3 Inflammasomes in Liver Fibrosis of Mice. Abstract:  OBJECTIVE: To investigate the effect of curcumol on NOD-like receptor thermoprotein domain 3 (NLRP3) inflammasomes, and analyze the mechanism underlying curcumol against liver fibrosis.METHODS: Thirty Kunming mice were divided into a control group, a model group and a curcumol group according to a random number table, 10 mice in each group. Mice were intraperitoneally injected with 40% carbon tetrachloride (CCl:peanut oil, 2:3 preparation) at 5 mL/kg for 6 weeks, twice a week, for developing a liver fibrosis model. The mice in the control group were given the same amount of peanut oil twice a week for 6 weeks. The mice in the curcumol group were given curcumol (30 mL/kg) intragastrically, and the mice in the model and control groups were given the same amount of normal saline once a day for 6 weeks. Changes in liver structure were observed by hematoxylin and eosin (HE) and Masson staining. Liver function, liver fiber indices, and the expression of interleukin (IL)-10 and tumor necrosis factor-α (TNF-α) levels were determined by automatic… Read more

    - greenmedinfo

    PMID:  Cell Prolif. 2021 Aug 3:e13107. Epub 2021 Aug 3. PMID: 34346124 Abstract Title:  Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease. Abstract:  OBJECTIVES: In recent years, cellular senescence has attracted a lot of interest in researchers due to its involvement in non-alcoholic fatty liver disease (NAFLD). However, the mechanism of cellular senescence is not clear. The purpose of this study was to investigate the effect of curcumol on hepatocyte senescence in NAFLD and the molecular mechanisms implicated.MATERIALS AND METHODS: LVG Golden Syrian hamsters, C57BL/6J mice and human hepatocyte cell line LO2 were used. Cellular senescence was assessed by analyses of senescence marker SA-β-gal, p16 and p21, H3K9me3, γ-H2AX and telomerase activity.RESULTS: The results showed that curcumol could inhibit hepatocyte senescence in both in vivo and in vitro NAFLD models, and the mechanism might be related to its regulation of ferritinophagy and subsequent alleviation of iron overload. Moreover, overexpression of nuclear receptor coactivator 4 (NCOA4) weakened the effect of curcumol on ferritinophagy-mediated iron overload and cellular senescence. Furthermore, we demonstrated that curcumol reduced the expression of NCOA4 by Yes-associated protein (YAP). In addition, depression of YAP could impair the effect of curcumol on iron… Read more

    - greenmedinfo

    PMID:  Biochem Pharmacol. 2021 Aug 21 ;192:114742. Epub 2021 Aug 21. PMID: 34428442 Abstract Title:  Curcumol inhibits EBV-positive Nasopharyngeal carcinoma migration and invasion by targeting nucleolin. Abstract:  Metastasis is a major cause of recurrence and death in patients with EBV-positive Nasopharyngeal carcinoma (NPC). Previous reports documented that curcumol has both anti-cancer and anti-viral effects, but there is little literature systematically addressing the mechanism of curcumol in EBV-positive tumors. Previously we found that nucelolin (NCL) is a target protein of curcumol in CNE2 cells, an EBV-negative NPC, and in this experiment, we reported a critical role for NCL in promoting migration and invasion of C666-1 cells, an EBV-positive NPC, and found that the expression of NCL determined the level of curcumol's efficacy. Mechanistically, NCL interacted with Epstein-Barr Virus Nuclear Antigen 1 (EBNA1) to activate VEGFA/VEGFR1/PI3K/AKT signaling pathway, which in turn promoted NPC cell invasion and metastasis. Moreover, further study showed that the differential expression of NCL and curcumol intervention only had a regulatory effect on the nuclear accumulation of VEGFR1, which strengthened the anti-cancer effect of curcumol mediated through NCL. Our findings indicated that curcumol exerted anti EBV-positive NPC invasion and metastasis by downregulating EBNA1 and inhibiting VEGFA/VEGFR1/PI3K/AKT signaling by targeting… Read more

    - greenmedinfo

    PMID:  J Photochem Photobiol B. 2021 Aug ;221:112247. Epub 2021 Jun 19. PMID: 34175580 Abstract Title:  Bellis perennis extract mitigates UVA-induced keratinocyte damage: Photoprotective and immunomodulatory effects. Abstract:  A need exists for further research elucidating the benefits of environmentally safe photoprotective agents against ultraviolet (UV) exposure, and plant extracts represent a human-friendly alternative formulation. This study was designed to evaluate the potential use of Bellis perennis extract (BPE), from the Asteraceae family, known as the common daisy or the English daisy, in cosmeceuticals as a photoprotective factor, using an in vitro model of UVA-induced keratinocyte damage. Human skin keratinocytes (HaCaT cell line) were incubated with BPE at 0.01, 0.1, or 1% in Dulbecco's Modified Eagle Medium (DMEM), and after 15 min they were submitted to UVA radiation at 5, 10, and 15 J/cmdoses, respectively. For comparative purposes, Polypodium leucotomos extract (PLE), known as the fern, was used as a positive control in assessing the photoprotective effect. After 24 h of UVA exposure, cell viability (MTT and LDH assays), levels of cleaved caspase-3, cyclooxygenase-2, IL-6, reactive oxygen species (ROS) and antioxidant enzyme (catalase, SOD, and glutathione peroxidase) activity were determined. UVA radiation at 5, 10, and 15 J/cmdoses reduced cell viability to 63%, 43%, and… Read more

    - greenmedinfo

    PMID:  Front Oncol. 2021 ;11:652008. Epub 2021 Jul 8. PMID: 34307130 Abstract Title:  Biochanin A Inhibits Glioblastoma GrowthRestricting Glycolysis and Mitochondrial Oxidative Phosphorylation. Abstract:  Abnormal metabolism serves a critical role in glioblastoma (GBM). Biochanin A (BCA), a flavonoid phenolic compound found in edible and herbal plants, has antioxidative and antitumor activities. However, it remains unclear whether BCA has an effect on energy metabolism. The aim of the present study was to evaluate the anticancer effects and molecular mechanism of the effect of BCA on energy metabolism. We observed that BCA inhibited the growth of U251 cells by the mitochondria-mediated intrinsic apoptotic pathway. BCA treatment reduced metabolic function, repressed mitochondrial membrane potential, and increased the production of reactive oxygen species (ROS) in GBM. In addition, we found that BCA decreased aerobic glycolysis by inactivation of the AKT/mTOR pathway. Taken together, the results demonstrate that treatment with BCA inhibited the proliferation of GBM by regulating metabolic reprogramming. read more Read more

    - greenmedinfo

    PMID:  Front Endocrinol (Lausanne). 2021 ;12:646720. Epub 2021 Jul 12. PMID: 34322090 Abstract Title:  Biochanin A Alleviates Cerebral Ischemia/Reperfusion Injury by Suppressing Endoplasmic Reticulum Stress-Induced Apoptosis and p38MAPK Signaling Pathwayand. Abstract:  We have previously shown that biochanin A exhibits neuroprotective properties in the context of cerebral ischemia/reperfusion (I/R) injury. The mechanistic basis for such properties, however, remains poorly understood. This study was therefore designed to explore the manner whereby biochanin A controls endoplasmic reticulum (ER) stress, apoptosis, and inflammation within fetal rat primary cortical neurons in response to oxygen-glucose deprivation/reoxygenation (OGD/R) injury, and in a rat model of middle cerebral artery occlusion and reperfusion (MCAO/R) injury. For the OGD/Rmodel system, cells were evaluated after a 2 h OGD following a 24 h reoxygenation period, whereasneurological deficits were evaluated following 2 h of ischemia and 24 h of reperfusion. The expression of proteins associated with apoptosis, ER stress (ERS), and p38 MAPK phosphorylation was evaluated in these samples. Rats treated with biochanin A exhibited reduced neurological deficits relative to control rats following MCAO/R injury. Additionally, GRP78 and CHOP levels rose following I/R modeling bothand, whereas biochanin A treatment was associated with reductions in CHOP levels but further increases in GRP78 levels. In addition, OGD/R or… Read more

    - greenmedinfo

    PMID:  Aging (Albany NY). 2021 07 21 ;13(14):18191-18222. Epub 2021 Jul 21. PMID: 34289449 Abstract Title:  Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer. Abstract:  This investigation attempted to discern whether formononetin restrained progression of triple-negative breast cancer (TNBC) by blocking lncRNA AFAP1-AS1-miR-195/miR-545 axis. We prepared TNBC cell lines (i.e. MDA-MB-231 and BT-549) and normal human mammary epithelial cell line (i.e. MCF-10A) in advance, and the TNBC cell lines were, respectively, transfected by pcDNA3.1-lncRNA AFAP1-AS1, si-lncRNA AFAP1-AS1, pcDNA6.2/GW/EmGFP-miR-545 or pcDNA6.2/GW/EmGFP-miR-195. Resistance of TNBC cells in response to 5-Fu, adriamycin, paclitaxel and cisplatin was evaluated through MTT assay, while potentials of TNBC cells in proliferation, migration and invasion were assessed via CCK8 assay and Transwell assay. Consequently, silencing of lncRNA AFAP1-AS1 impaired chemo-resistance, proliferation, migration and invasion of TNBC cells (read more Read more

    - greenmedinfo

    PMID:  Bioengineered. 2021 Dec ;12(1):4887-4898. PMID: 34369277 Abstract Title:  Formononetin protects against ox-LDL-induced endothelial dysfunction by activating PPAR-γ signaling based on network pharmacology and experimental validation. Abstract:  Formononetin (FMNT), a flavonoid identified from the Chinese herb, possesses anti-inflammatory or anti-oxidative properties in different human diseases. This study aims to comprehensively elucidate the function of FMNT in atherosclerosis and its underlying mechanisms. Online public databases were used to identify the drug-disease targets. Protein-protein interaction (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were applied to explore the potential targets and signaling pathways involved in FMNT against atherosclerosis. Human umbilical vein endothelial cells (HUVECs) were exposed to oxidized low-density lipoprotein (ox-LDL) to construct an atherosclerosis cell model. Endothelial cell function was assessed via examining cell proliferation, inflammatory factors, oxidative markers, reactive oxygen species (ROS), and apoptosis. Western blot was performed to detect the expression of cyclooxygenase-2 (COX-2), endothelial nitric oxide synthase (eNOS), cleaved caspase-3, and peroxisome proliferator-activated receptor-γ (PPAR-γ). A total of 39 overlapping target genes of FMNT and atherosclerosis were identified. Through the PPI network analysis, 14 hub genes were screened and found to be closely relevant to inflammation, oxidative stress, and apoptosis. Results of… Read more

    - greenmedinfo

    PMID:  Drug Res (Stuttg). 2021 Sep 13. Epub 2021 Sep 13. PMID: 34517419 Abstract Title:  Theaflavin-3'-O-gallate a Black-tea Constituent Blocked SARS CoV-2 RNA dependant RNA Polymerase Active-site with Better Docking Results than Remdesivir. Abstract:  BACKGROUND: Replication of SARS-CoV-2 depends on viral RNA-dependent RNA-polymerase (RdRp). Remdesivir, the broad-spectrum RdRp inhibitor acts as nucleoside-analogues (NAs). Remdesivir has initially been repurposed as a promising drug against SARS-CoV-2 infection with some health hazards like liver damage, allergic reaction, low blood-pressure, and breathing-shortness, throat-swelling. In comparison, theaflavin-3'-gallate (TFMG), the abundant black tea component has gained importance in controlling viral infection. TFMG is a non-toxic, non-invasive, antioxidant, anticancer and antiviral molecule.RESULTS: Here, we analyzed the inhibitory effect of theaflavin-3'-gallate on SARS CoV-2 RdRp in comparison with remdesivir by molecular-docking study. TFMG has been shown more potent in terms of lower Atomic-Contact-Energy (ACE) and higher occupancy of surface area; -393.97 Kcal/mol and 771.90 respectively, favoured with lower desolvation-energy; -9.2: Kcal/mol. TFMG forms more rigid electrostatic and H-bond than remdesivir. TFMG showed strong affinity to RNA primer and template and RNA passage-site of RdRp.CONCLUSIONS: TFMG can block the catalytic residue, NTP entry site, cation binding site, nsp7-nsp12 junction with binding energy of -6. 72 Kcal/mol with Ki value of… Read more

    - greenmedinfo

    PMID:  BMC Oral Health. 2021 Sep 15 ;21(1):447. Epub 2021 Sep 15. PMID: 34525984 Abstract Title:  Effect of epigallocatechin gallate on dental biofilm of Streptococcus mutans: An in vitro study. Abstract:  BACKGROUND: Streptococcus mutans (S. mutans) plays a major role in the formation of dental caries. The aim of this study was to examine the effect of the green tea polyphenol, epigallocatechin gallate (EGCG), on biofilm formation of S. mutans.METHODS: Following exposure to increasing concentrations of EGCG, the planktonic growth was measured by optical density and the biofilm biomass was quantified by crystal violet staining. Exopolysaccharides (EPS) production was visualized by confocal scanning laser microscopy, and the bacterial DNA content was determined by quantitative polymerase chain reaction (qPCR). Gene expression of selected genes was analyzed by real time (RT)-qPCR and membrane potential was examined by flow cytometry.RESULTS: We observed that EGCG inhibited in a dose-dependent manner both the planktonic growth and the biofilm formation of S. mutans. Significant reduction of S. mutans biofilm formation, DNA content, and EPS production was observed at 2.2-4.4 mg/ml EGCG. EGCG reduced the expression of gtfB, gtfC and ftf genes involved in EPS production, and the nox and sodA genes involved in the protection against oxidative… Read more

    - greenmedinfo

    PMID:  Molecules. 2021 Aug 31 ;26(17). Epub 2021 Aug 31. PMID: 34500738 Abstract Title:  Inhibitory Effect of Fisetin onα-Glucosidase Activity: Kinetic and Molecular Docking Studies. Abstract:  The inhibition ofα-glucosidase is a clinical strategy for the treatment of type 2 diabetes mellitus (T2DM), and many natural plant ingredients have been reported to be effective in alleviating hyperglycemia by inhibiting α-glucosidase. In this study, the α-glucosidase inhibitory activity of fisetin extracted fromScop. was evaluated in vitro. The results showed that fisetin exhibited strong inhibitory activity with an ICvalue of 4.099× 10mM. Enzyme kinetic analysis revealed that fisetin is a non-competitive inhibitor ofα-glucosidase, with an inhibition constant value of 0.01065 ± 0.003255 mM. Moreover, fluorescence spectrometric measurements indicated the presence of only one binding site between fisetin and α-glucosidase, with a binding constant (lgKa) of 5.896 L·mol. Further molecular docking studies were performed to evaluate the interaction of fisetin with several residues close to the inactive site ofα-glucosidase. These studies showed that the structure of the complex was maintained by Pi-Sigma and Pi-Pi stacked interactions. These findings illustrate that fisetin extracted fromScop. is a promising therapeutic agent for the treatment of T2DM. read more Read more

    - greenmedinfo

    PMID:  J Agric Food Chem. 2021 Sep 10. Epub 2021 Sep 10. PMID: 34505780 Abstract Title:  Fisetin Improves Hyperuricemia-Induced Chronic Kidney Disease via Regulating Gut Microbiota-Mediated Tryptophan Metabolism and Aryl Hydrocarbon Receptor Activation. Abstract:  The intestinal flora serves a critical role in the development of hyperuricemia-induced chronic kidney disease (CKD). We previously found that natural flavonol fisetin exhibited nephroprotective effects in hyperuricemic mice. However, the mechanism remains largely unknown. To investigate the underlying mechanism of fisetin, mice were fed with potassium oxonate and adenine to introduce hyperuricemia-induced CKD. Fisetin improved kidney function, ameliorated renal fibrosis, and restored enteric dysbacteriosis in hyperuricemia-induced CKD mice. Meanwhile, gut microbiota-derived tryptophan metabolites, especially l-kynurenine, showed correlations with nephroprotective profiles of fisetin. Additionally, the kidney expression of the aryl hydrocarbon receptor (AHR), an endogenous receptor of l-kynurenine, was enhanced in hyperuricemic mice and further reduced in fisetin-treated mice. Finally, in vitro results showed that inhibition of AHR activation attenuated l-kynurenine-induced fibrosis. These results highlighted that fisetin protected against hyperuricemia-induced CKD via modulating gut microbiota-mediated tryptophan metabolism and AHR activation. read more Read more

    - greenmedinfo

    PMID:  Eur J Pharmacol. 2021 Sep 10:174492. Epub 2021 Sep 10. PMID: 34516952 Abstract Title:  Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review. Abstract:  Neurodegenerative disorders pose a significant health burden and imprint a debilitative impact on the quality of life. Importantly, aging is intricately intertwined with the progression of these disorders, and their prevalence increases with a rise in the aging population worldwide. In recent times, fisetin emerged as one of the potential miracle molecules to address neurobehavioral and cognitive abnormalities. These effects were attributed to its actions on several macromolecules and multiple molecular mechanisms. Fisetin belongs to a class of flavonoids, which is found abundantly in several fruits and vegetables. Fisetin has manifested several health benefits in preclinical models of neurodegenerative diseases such as Alzheimer's disease, Vascular dementia, and Schizophrenia. Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, Stroke, Traumatic brain injury (TBI), and age-associated changes. This review aimed to evaluate the potential mechanisms and pharmacological effects of fisetin in treating several neurological diseases. This review also provides comprehensive data on up-to-date recent literature and highlights the various mechanistic pathways pertaining to fisetin's role in treating various neurodegenerative diseases. read more Read more

    - greenmedinfo

    PMID:  Int J Mol Sci. 2020 Feb 25 ;21(5). Epub 2020 Feb 25. PMID: 32106603 Abstract Title:  Corylifol A fromL. Enhances Myogenesis and Alleviates Muscle Atrophy. Abstract:  Inflammatory conditions caused by cancer, chronic diseases or aging can lead to skeletal muscle atrophy. We identified myogenic compounds from(PC), a medicinal plant that has been used for the treatment of inflammatory and skin diseases. C2C12 mouse skeletal myoblasts were differentiated in the presence of eight compounds isolated from PC to evaluate their myogenic potential. Among them, corylifol A showed the strongest transactivation of MyoD and increased expression of myogenic markers, such as MyoD, myogenin and myosin heavy chain (MHC). Corylifol A increased the number of multinucleated and MHC-expressing myotubes. We also found that the p38 MAPK signaling pathway is essential for the myogenic action of corylifol A. Atrophic condition was induced by treatment with dexamethasone. Corylifol A protected against dexamethasone-induced myotube loss by increasing the proportion of multinucleated MHC-expressing myotubes compared with dexamethasone-damaged myotubes. Corylifol A reduced the expression of muscle-specific ubiquitin-E3 ligases (MAFbx and MuRF1) and myostatin, while activating Akt. These dual effects of corylifol A, inhibition of catabolic and activation of anabolic pathways, protect myotubes against dexamethasone damage. In summary,… Read more

    - greenmedinfo

    PMID:  Front Pharmacol. 2019 ;10:1589. Epub 2020 Jan 28. PMID: 32116659 Abstract Title:  Five Constituents inL. Attenuate Palmitic Acid-Induced Hepatocyte InjuryInhibiting the Protein Kinase C-α/Nicotinamide-Adenine Dinucleotide Phosphate Oxidase Pathway. Abstract:  L. (PC) is a traditional Chinese herb used to treat yang deficiency of the spleen and kidney in pediatric disease. Our previous studies have found that PC can alleviate the liver oxidative stress of juvenile mice with nonalcoholic steatohepatitis (NASH), and its mechanism is related to the inhibition of the protein kinase C-α (PKC-α)/nicotinamide-adenine dinucleotide phosphate oxidase (NOX) signaling pathway. The aim of this study was to confirm the aforementioned drug targetand to conduct preliminary screening for some effective compounds of PC on the treatment of NASH. A primary hepatocyte model of non alcoholic fatty liver disease was established by palmitic acid. The existence of,,,, andwere identified by ultra-performance liquid chromatography. Then, five PC compounds were administered. Intracellular triglyceride and total cholesterol content, the cell supernatant alanine aminotransferase and aspartate aminotransferase, and hepatocellular superoxide anion were examined. The changes of PKC-α/NOX signaling pathways in hepatocytes were also determined. Furthermore, PKC-α activator phorbol 12-myristate 13-acetate was administered for 4 h before Psoralen intervention was conducted again to detect the changes of… Read more

    - greenmedinfo

    PMID:  J Food Sci. 2020 Jul ;85(7):2216-2226. Epub 2020 Jun 24. PMID: 32579753 Abstract Title:  Psoralea corylifolia L. extract ameliorates nonalcoholic fatty liver disease in free-fatty-acid-incubated HEPG2 cells and in high-fat diet-fed mice. Abstract:  Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that is closely related to metabolic syndrome. We investigated the effect of a Psoralea corylifolia L. (PC) seeds extract (PCE) on NAFLD. PC seeds were extracted using different ethanol concentrations to produce five extracts, and the 70% ethanol PCE, which had the highest phenolic content, was used in subsequent in vitro and in vivo experiments. The inhibitory effect of PCE on hepatic steatosis was estimated using HepG2 cells treated with oleic acid (OA). In addition, an in vivo NAFLD model was established using high-fat diet (HFD)-induced obese C57BL/6 mice. Obesity was induced in mice over 14 weeks. PCE (100 or 200 mg/kg/day) was administered orally to mice after 8 weeks of the 14-week treatment period for 6 weeks. PCE suppressed lipid accumulation in OA-treated HepG2 cells. PCE ameliorated the antioxidant activity suppressions induced by the HFD. In addition, both PCE100 and PCE200 groups reduced lipid accumulation and the expression levels of inflammatory proteins as compared with… Read more

    - greenmedinfo

    PMID:  Int Immunopharmacol. 2020 Dec ;89(Pt A):107000. Epub 2020 Oct 8. PMID: 33039956 Abstract Title:  Bakuchiol from Psoralea corylifolia L. Ameliorates acute kidney injury and improves survival in experimental polymicrobial sepsis. Abstract:  Bakuchiol (BAK) is a prenylated phenolic mono-terpene extracted from the fruit of Psoralea corylifolia L., which exerts a protective effect on organs. However, whether BAK has a protective effect on sepsis-induced acute kidney injury (S-AKI) is not clear. In our study we have demonstrated for the first time that pretreatment with BAK significantly reduced bacterial load, inflammation and renal oxidative stress in caecal ligation and puncture (CLP)-induced sepsis. Moreover, CLP-induced renal histological damage, mortality and clinical signs were markedly attenuated by BAK. Additionally, BAK inhibited sepsis-induced activation of NF-κB and p38 MAPK signaling in the kidneys. The evidence presented here has confirmed that BAK exerts multifunctional activity in protection against S-AKI. This action of BAK is probably due to the blockade of the NF-κB and p38 MAPK signaling pathways. Our findings offer a novel potential for BAK inprotection against sepsis and S-AKI. read more Read more

    - greenmedinfo

    PMID:  Pharmacol Res. 2021 02 ;164:105291. Epub 2020 Nov 27. PMID: 33253817 Abstract Title:  Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 andβ3-AR activation. Abstract:  Brown adipose tissue (BAT) activation or beige adipocytes in white adipocytes (WAT) (browning) is a novel strategy against obesity. Corylin, a flavonoid compound extract from Psoralea corylifolia L., has been shown to exert anti-inflammatory, anticancer, and anti-atherosclerotic effects and ameliorate hyperlipidemia and insulin resistance. However, the therapeutic effect of corylin on obesity remains unknown. The objective of this study was to evaluate the effect of corylin on browning or obesity. Here, we report that corylin induced browning by elevating the expression levels of beige- or browning-specific marker genes, including cited1, hoxc9, pgc1α, prdm16, and ucp1, in 3T3-L1 adipocytes, WAT and BAT. Moreover, corylin also strikingly reduced body weight and fat accumulation and increased insulin sensitivity, mitochondrial biogenesis, and β-oxidation in HFD- and DIO-treated mice. The browning and lipolysis effects of corylin were abolishedby sirtuin 1 (SIRT1) inhibitor (EX527) and β3-adrenergic receptor (β3-AR) antagonist (L-748,337) treatment. The possible molecular mechanism of corylin on the browning and lipolysis of adipocytes is through SIRT1- or β3-AR-dependent pathways. The study suggested that corylin exerts… Read more

    - greenmedinfo

    PMID:  J Ethnopharmacol. 2021 Jun 12 ;273:113844. Epub 2021 Jan 21. PMID: 33485982 Abstract Title:  Psoralea corylifolia L. extract ameliorates benign prostatic hyperplasia by regulating prostate cell proliferation and apoptosis. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Psoralea corylifolia L. seed (PCL), commonly known as "Poguzhi" or "BuguZhi", has been widely used to treat kidney yang deficiency in traditional Chinese medicine (TCM) where tonifying the yang deficiency is a representative understanding for treatment of hormonal deficiency disorders such as enuresis, oliguria, and prostatic diseases. Although PCL has been commonly used to treat problems of the urinary system, its efficacy against benign prostatic hyperplasia (BPH) has not yet been reported.AIM OF THE STUDY: In the present study, we aimed to assess the in vitro and in vivo efficacy of PCL against BPH, a condition which negatively impacts quality of life in men.MATERIALS AND METHODS: Normal human prostate cell lines, RWPE-1 and WPMY-1 cells, were stimulated with 10 nM dihydrotestosterone (DHT) to establish an in vitro BPH model. Subsequently, cells were treated with 100 or 200 μg/ml PCL, which inhibited cell proliferation without cytotoxicity, to evaluate the anti-BPH effect of PCL. Eight-week-old male Wistar rats were castrated, except for those in the control group (Con), and BPH was induced… Read more

    - greenmedinfo

    PMID:  Horm Mol Biol Clin Investig. 2021 Sep 9. Epub 2021 Sep 9. PMID: 34496167 Abstract Title:  Psoralidin exerts anti-tumor, anti-angiogenic, and immunostimulatory activities in 4T1 tumor-bearing balb/c mice. Abstract:  BACKGROUND: Psoralidin as a compound of theseeds exhibited several anti-cancer potentials in various cancers.MATERIALS AND METHODS: In this study, 4T1 tumor-bearing Balb/c mice were treated by intraperitoneal administration of Psoralidin, and Paraffin, as a control group to investigate anti-tumor, anti-angiogenic, and immunostimulatory activities in breast cancer. Body weight and tumor volume measurement were performed. Hematoxylin and Eosin (H&E) staining as well as immunohistochemistry for Ki-67, CD31 and VEGF markers were conducted. In addition, ELISA assay was performed for evaluating the serum level of IFN-γ and IL-4. Moreover, real time assay was performed to evaluate the expression of angiogenesis and immunostimulatory related genes.RESULTS: There were no significant changes in the body weight of all animal groups. The anti-cancer effects of Psoralidin were significantly observed after 24 days of the last treatment, confirmed by smaller tumor volume and also H&E staining. The expression level of Ki-67, CD31 and VEGF were significantly decreased in tumor tissues of the Psoralidin-treated group in comparison with Paraffin-treated group. Moreover, there was a significant reduction in the serum… Read more

    - greenmedinfo

    PMID:  Respir Physiol Neurobiol. 2021 10 ;292:103707. Epub 2021 Jun 1. PMID: 34087492 Abstract Title:  Bakuchiol ameliorates cerebral ischemia-reperfusion injury by modulating NLRP3 inflammasome and Nrf2 signaling. Abstract:  Cerebral ischemia/reperfusion (I/R) injury is a common cerebrovascular disease with high mortality. Bakuchiol (BAK), extracted from the seeds of psoralea corylifolia, exhibits anti-inflammatory effects on lung, kidney and heart injuries. However, the effect of BAK on brain I/R injury remains elusive. In our study, a cerebral I/R model in mice was established by 1-h middle cerebral artery occlusion and 24-h reperfusion (1-h MCAO/24-h R). Prior to it, mice were gavaged with BAK (2.5 or 5 mg/kg) per day for 5 days. BAK pre-treatment improved neurological deficit, and reduced infarct volume, cerebral edema and neuronal injury in MCAO/R-injured mice. BAK decreased the number of Iba1-immunoreactive cells in the brain, indicating a reduction of microglial activation. BAK also reducedthe expressions of NLRP3, ASC, cleaved-caspase-1, IL-1β and IL-18. BAK triggered Nrf2 nuclear accumulation and elevated HO-1 level. Further, the role of BAK was explored in BV-2 microglia with 3-h oxygen-glucose deprivation/24-h reperfusion (3-h OGD/24-h R). It was found that the functions of BAK in vitro were consistent with those in vivo, as manifested by reduced NLRP3… Read more

    - greenmedinfo

    PMID:  J Agric Food Chem. 2021 Jun 9 ;69(22):6260-6270. Epub 2021 May 27. PMID: 34043345 Abstract Title:  Bavachinin Induces G2/M Cell Cycle Arrest and Apoptosis via the ATM/ATR Signaling Pathway in Human Small Cell Lung Cancer and Shows an Antitumor Effect in the Xenograft Model. Abstract:  Lung cancer is grouped into small cell lung cancer (SCLC) and non-SCLC (NSCLC). SCLC exhibits a poor prognosis, and the current anticancer treatment remains unsatisfactory. Bavachinin, present in the seed of, shows anti-inflammatory effects, immune modulation, and anticancer potency. This study aims to investigate the antitumor effect of bavachinin on SCLC and its underlying mechanism. The SCLC cell line H1688 was treated with different concentrations of bavachinin and showed decreased viability with arrested G2/M and sub-G1 phase cell accumulation at a concentration as low as 25μM. Expression levels of caspase-3, -8, and -9, as well as Fas, FasL, and Bax, increased with the concentration of bavachinin. The accumulated sub-G1 cells and annexin V confirmed increasing apoptotic cancer cells after treatment. The accumulated G2/M phase cells with increasing levels of phosphorylated CDC25C, CDC2, ATM/ATR, and CHK2/CHK1 confirmed the arrested cell cycle caused by bavachinin via a dose-dependent manner. This phenomenon can be reversed by an… Read more

    - greenmedinfo

    PMID:  Life (Basel). 2021 Jun 21 ;11(6). Epub 2021 Jun 21. PMID: 34205531 Abstract Title:  L. Ameliorates Collagen-Induced Arthritis by Reducing Proinflammatory Cytokines and Upregulating Myeloid-Derived Suppressor Cells. Abstract:  : Rheumatoid arthritis is an autoimmune disease that may lead to severe complications. The fruit ofL. (PCL) is widely used in traditional Chinese medicine as a well-known herbal treatment for orthopedic diseases. However, there is a lack of studies of its effects on rheumatoid arthritis. The purpose of the study was to investigate the effects and mechanisms of concentrated herbal granules of PCL on rheumatoid arthritis to provide some insights for future development of new drug for the treatment of rheumatoid arthritis.: We used collagen-induced arthritis (CIA) DBA/1J mice as an experimental model to mimic human rheumatoid arthritis. The mice were immunized with collagen on days 0 and 21 and then orally administered 200 mg/kg/day PCL on days 22-49. Starch was used as a control. The mice were sacrificed on day 50. Clinical phenotypes, joint histopathology, and immunological profiles were measured.: Compared to the CIA or CIA + Starch group, the CIA + PCL group had significantly ameliorated clinical severity and decreased paw swelling. Histopathological analysis of the hind paws showed… Read more

    - greenmedinfo

    PMID:  Front Pharmacol. 2021 ;12:696981. Epub 2021 Aug 11. PMID: 34456723 Abstract Title:  A Nano-Pharmaceutical Formula of Quercetin Protects from Cardiovascular Complications Associated with Metabolic Syndrome. Abstract:  Metabolic syndrome (MetS) is closely associated with the development of cardiovascular diseases. We recently developed a nano-preparation of the flavonoid quercetin (QU) in a self-nanoemulsifying drug delivery system (SNEDDS). The latter comprised a mixture composed of pumpkin seed oil, D-α-Tocopherol polyethylene glycol 1,000 succinate and polyethylene glycol. The QU SNEDDS preparations exhibited a considerably higher bioavailability compared with the standard quercetin suspension. Here, we investigated whether the quercetin loaded SNEDDS could offer better protection compared withthe standard formulation against cardiovascular complications of MetS in rats. MetS was induced by high fructose, high salt and high fat diet for 12 weeks while the nano-preparation or the standard suspension of quercetin was orally administered for the last 6 weeks. Compared to little effect forthe standard quercetin suspension (MQ), the treatment of MetS rats with the quercetin loaded SNEDDS (MNQ) virtually abolished the depressant effect of MetS on contractility index (control, 114 ± 4; MetS, 92 ± 3; MQ, 100 ± 2; MNQ, 114 ± 6 1/s) and rate of rise in left ventricular pressure (dP/dtmax) (control, 8,171… Read more

    - greenmedinfo

    PMID:  Nutr Res. 2021 Jul 23 ;93:69-78. Epub 2021 Jul 23. PMID: 34428717 Abstract Title:  Pecan-enriched diets decrease postprandial lipid peroxidation and increase total antioxidant capacity in adults at-risk for cardiovascular disease. Abstract:  Pecans are a rich source of antioxidants, but the effect of regular consumption on post-meal responses is unknown. The objective of this study was to examine the impact of daily pecan consumption for 8 weeks on fasting and postprandial lipid peroxidation, total antioxidant capacity (TAC), and tocopherols in adults at higher risk for cardiovascular disease (CVD) (hypercholesterolemia or elevated adiposity). We hypothesized that daily pecan consumption would result in increased fastingγ-tocopherol, increased fasting and postprandial TAC, and decreased fasting and postprandial lipid peroxidation. This was a randomized, parallel, controlled trial with 3 treatments: two pecan groups and a nut free control (n = 16). The ADD group (n = 15) consumed pecans as part of a free-livingdiet, and the SUB group (n = 16) substituted the pecans for isocaloric foods from their habitual diet. At the pre- and post-intervention, a high saturated fat breakfast shake was consumed with postprandial blood draws over 2h. In the ADD and SUB groups, postprandial lipid peroxidation was suppressed (iAUC: 0.9 ± 1.3 to -2.9 ± 2.0 and… Read more

    - greenmedinfo

    PMID:  Food Funct. 2021 Aug 11. Epub 2021 Aug 11. PMID: 34378609 Abstract Title:  Chia seed (L.) consumption and lipid profile: a systematic review and meta-analysis. Abstract:  Chia (Salvia hispanica L.) is an annual herbaceous plant, originally from southern Mexico and northern Guatemala - nowadays grown all over the world. In recent years, there has been an increase in demand for plant foods with health-promoting properties, and chia is a main actor in this process due to its high nutritional and functional value and its chemical composition rich in PUFAs, mainlyω-3, as well as protein, dietary fiber, and bioactive compounds. Chia has been explored in different research models for health and the prevention of human diseases. Evidence has suggested potential for improving insulin resistance, disordered lipid profiles, glucose tolerance and even adiposity. The aim of this study was to evaluate the effect of consumption of chia seeds on the lipid profile, triglycerides, and serum ω-3 fatty acids in adults. This systematic review included all randomized controlled trials (parallel or crossover design) published up to August 2020 in the main databases Medline, Embase, Scopus, Web of Science, and Scielo. Two independent authors selected and extracted data from those articles. After the… Read more

    - greenmedinfo

    PMID:  J Food Sci. 2021 Jul ;86(7):2861-2871. Epub 2021 Jun 2. PMID: 34076264 Abstract Title:  Anticancer activity of protein fractions from chia (Salvia hispanica L.). Abstract:  Salvia hispanica demonstrated to be a source of protein fractions with anticancer activity. The effect of the protein fractions read more Read more

    - greenmedinfo

    PMID:  Cardiovasc Hematol Agents Med Chem. 2021 Aug 11. Epub 2021 Aug 11. PMID: 34387170 Abstract Title:  Chenopodium quinoa Exhibits Antihyperglycemic Activity in Streptozotocin-Induced Diabetic Rats. Abstract:  AIMS: The aim of the study was to evaluate the antihyperglycemic effect of Chenopodium quinoa.BACKGROUND: Chenopodium quinoa is a pseudocereal plant with several medicinal properties.OBJECTIVE: The goal of this investigation was to determine the antihyperglycemic activity of Chenopodium quinoa in both normal and streptozotocin(STZ)-induced diabetic rats.METHODS: In this study, the effect of the aqueous extract of Chenopodium quinoa seeds (AECQS) (60 mg/kg) on blood glucose levels was evaluated in both normal and diabetic rats after a single (6 hours) and repeated oral administration (7 days of treatment). The effect of this herb on glucose tolerance and lipid profile was also studied. Additionally, histopathological examination of liver was carried out using the Hematoxylin-Eosin method. Furthermore, the in vitro antioxidant activity as well as a preliminary phytochemical screening and quantification of some secondary metabolites (phenolic compounds, flavonoids and tannins) were performed according to standard methods.RESULTS: AECQS produced a significant lowering effect on plasma glucose levels in STZ-induced diabetic rats. In addition, this extract exhibited a remarkable amelioration on hepatic histopathology in diabetic rats. In addition,… Read more

    - greenmedinfo

    PMID:  Nutrients. 2021 Jul 17 ;13(7). Epub 2021 Jul 17. PMID: 34371955 Abstract Title:  Administration with Quinoa Protein Reduces the Blood Pressure in Spontaneously Hypertensive Rats and Modifies the Fecal Microbiota. Abstract:  Despite the well-established role of quinoa protein as the source of antihypertensive peptides through in vitro enzymolysis, there is little evidence supporting the in vivo antihypertensive effect of intact quinoa protein. In this study, in vivo study on spontaneously hypertensive rats (SHRs) was conducted by administering quinoa protein for five weeks. Gastrointestinal content identification indicated that many promising precursors of bioactive peptides were released from quinoa protein under gastrointestinal processing. Quinoa protein administration on SHRs resulted in a significant decrease in blood pressure, a significant increase in alpha diversity, and microbial structure alternation towards that in non-hypertension rats. Furthermore, blood pressure was highly negatively correlated with the elevated abundance of genera in quinoa protein-treated SHRs, such asand. Interestingly, the fecal microbiota in quinoa protein-treated SHRs shared more features in the composition of genera with non-hypertension rats than that of the captopril-treated group. These results indicate that quinoa protein may serve as a potential candidate to lower blood pressure and ameliorate hypertension-related gut dysbiosis. read more Read more

    A study led by dermatologists suggests that a common inflammatory skin condition may stem from poorly regulated sex hormones. The finding could offer an unexpected new target to fight this condition. Read more

    Being overweight or having obesity, weight that is higher than what is considered healthy for an individual's height, is a major risk factor for high blood pressure. A healthy diet, more physical activity and less sedentary time are recommended to reduce blood pressure for people who are overweight or have obesity; however, evidence of long-term weight loss and sustained blood pressure reductions from these lifestyle changes is limited. New weight-loss medications and bariatric surgery have shown benefits in both long-term weight loss and improved blood pressure, which can reduce the long-term, negative impact of high blood pressure on organ damage. Read more

    Plants regulate their growth using hormones, including a group called strigolactones that prevent excessive budding and branching. Strigolactones also help plant roots form symbiotic relationships with microorganisms that allow the plant to absorb nutrients from the soil. These two factors have led to agricultural interest in using strigolactones to control the growth of weeds and root parasites, as well as improving nutrient uptake. These root-extruding compounds also stimulate germination of witchweeds and broomrapes, which can cause entire crops of grain to fail, making thorough research essential prior to commercial development. Now scientists have synthesized strigolactones from microbes. Read more

    Infants coming from homes with domestic violence often go on to have worse academic outcomes in school due to neurodevelopmental lags and a higher risk for a variety of health issues, including gastrointestinal distress, trouble eating and sleeping, as well as stress and illness. Read more

    Allergic reactions to the new mRNA-based COVID-19 vaccines are rare, typically mild and treatable, and they should not deter people from becoming vaccinated, according to researchers. Read more

    Researchers have made a surprise discovery about how immune 'sentinel' cells are maintained, which could have implications for drugs in development for treating cancer. Read more

    Researchers attempted to unravel such mechanisms by adopting non-invasive diffusion magnetic resonance imaging (MRI) to study the brains of SLE patients, particularly the white matter, coupled with computerized neuropsychological assessment. White matter lies beneath the grey matter cortex in the human brain and comprises millions of bundles of nerve fibers that transmit signals to different brain regions. Read more

    Imagine having your own digital personal chef; ready to cook whatever you want, tailoring the shape, texture, and flavor just for you -- all at the push of a button. Engineers have been working on doing just that, using lasers for cooking and 3D printing technology for assembling foods. In their new study they discovered that laser-cooked meat shrinks 50% less, retains double the moisture content, and shows similar flavor development to conventionally cooked meat. Read more

    Researchers have extracted Ancient DNA from human bones to re-write early Japanese history by underlining that modern day populations in Japan have a tripartite genetic origin -- a finding that refines previously accepted views of a dual genomic ancestry. Read more

    Researchers have developed an approach to estimating when a person who is at high risk of Alzheimer's dementia but has no cognitive symptoms will start showing signs of cognitive decline. The approach is based on data from a single brain scan, combined with the person's age. Read more

    A new technique for measuring turbulent flows has been developed. By using fibers rather than particles -- the usual method of measurement -- the researchers could get a more detailed picture of turbulent flows. Read more

    Scientists have assembled a quantitative assessment for agriculture sustainability for countries around the world based not only on environmental impacts, but economic and social impacts, as well. The Sustainable Agriculture Matrix, or SAM, provides independent and transparent measurements of agricultural sustainability at a national level that can help governments and organizations to evaluate progress, encourage accountability, identify priorities for improvement, and inform national policies and actions towards sustainable agriculture around the globe. Read more

    A newly discovered manipulation mechanism used by parasitic bacteria to slow down plant aging, may offer new ways to protect disease-threatened food crops. Research has identified a manipulation molecule produced by Phytoplasma bacteria to hijack plant development. When inside a plant, this protein causes key growth regulators to be broken down, triggering abnormal growth. The new findings show how the bacterial protein known as SAP05 manipulates plants by taking advantage of some of the host's own molecular machinery. Read more

    The capacity of coral reefs to provide ecosystem services such as food and jobs, relied on by millions of people worldwide, has declined by half since the 1950s, according to a new study. Other findings are equally bleak: the authors found that global coverage of living corals had declined by about half since the 1950s and consequently, the diversity of species had also declined, by more than 60 per cent. Finding targets for recovery and climate adaptation would require a global effort, while also addressing needs at a local level, authors say. Read more

    Researchers are finding a link between the increased presence of certain bacteria in a gut biome and colon cancer. Read more

    Researchers have created a novel automated program that accurately and quickly counts micronuclei in stained images. Micronuclei are small nucleus-like structures that are markers of pathologies such as cancer. The development of this automated program will be useful for future research into micronuclei and may aid in the diagnosis and tracking of a range of pathologies. Read more

    Researchers are using high-tech 3D facial scans to give us a better understanding of the genetic causes of autism. Read more

    Researchers established an organoid biobank to search for the genes that are essential for the spreading of a SARS-CoV2 infection. Their study highlights the usefulness of organoids for basic research into coronaviruses, as well as highlighting potential drug targets. Read more

    Seeds that would otherwise lie dormant will spring to life with the aid of a new chemical. Read more

    Global warming is causing a rapid decline in sea-ice area, which affects weather patterns and, surprisingly, increases wave height in the Arctic. In a new study, Japanese scientists analyzed data from a 2018 research expedition into Chukchi Sea to demonstrate the peculiar link that exists between sea spray induced by high waves and the formation of ice-containing clouds. Their results pave the way for more accurate climate change and sea-ice models. Read more

    Researchers have discovered a previously unknown species of otter from 11.4-million-year-old strata at the Hammerschmiede fossil site. Read more

    Six stages of engagement in treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) have been reported by researchers based on a diverse study, inclusive of parents of predominantly racial and ethnic minority children with ADHD. Read more

    A family of fishes, called the cichlids, in Africa's Lake Malawi is helping researchers refine our understanding of how evolution works. Read more

    The ability to visualize cancerous tumors and metastatic tissue three dimensionally (3D) can help clinicians diagnose the precise type and stage of cancer, while also informing the best treatment methods. To obtain an even clearer tissue for imaging, a research team based in Japan has tested the effectiveness of specialized hydrogels. Acting as a 3D molecular network, these hydrogels can rapidly remove fats from tissues, which are a factor in tissue opacification, without losing their structure. The material is used in several biomedical devices, including contact lenses. Read more

    An unprecedented review of the aquatic foods sector has uncovered how fisheries and aquaculture can play a greater role in delivering healthy diets and more sustainable, equitable and resilient food systems around the world. Read more

    New research shows that mRNA COVID-19 vaccines are effective at inducing T-cell responses in multiple sclerosis patients who receive B cell-depleting infusions even if their antibody responses are diminished. Read more

    Researchers find that youth who witness the abuse of a brother or sister by a parent can be just as traumatized as those witnessing violence by a parent against another parent. Such exposure is associated with mental health issues like depression, anxiety and anger. Read more

    A new study finds that SARS-CoV-2 is evolving toward more efficient aerosol generation, and loose-fitting masks provide significant but only modest source control. Until vaccination rates are very high, continued layered controls, including improved ventilation, increased filtration, UV air sanitation, and tight-fitting masks are critical to protect people in public-facing jobs and indoor spaces, researchers urge. Read more

    New research led by the University of Kent and University of Reading has found that fruit and vegetable consumption and exercise can increase levels of happiness. Read more

    Fish can drown. While it may not seem like it, fish do require oxygen to breathe; it's just that they get what they need from the oxygen dissolved in water rather than in the air. Too little oxygen spells trouble for our finned friends, which have to move or else suffer ill effects. Read more

    Data sets that are biased by having too many genomes from people with European ancestry can still be applied to other ancestry groups to predict their risk of developing breast and prostate cancer, researchers report. Read more

    A new study finds that pancreatic cells display an adaptive response to repeated inflammation that initially protects against tissue damage but can promote tumor formation in the presence of mutant KRAS. Read more

    Inspired by a kind of tree leaf, scientists discovered that the spreading direction of different liquids deposited on the same surface can be steered, solving a challenge that has remained for over two centuries. This breakthrough could ignite a new wave of using 3D surface structures for intelligent liquid manipulation with profound implications for various scientific and industrial applications, such as fluidics design and heat transfer enhancement. Read more

    In a surprising new finding in mice, researchers have discovered that many genes linked to human cancer block the body's natural defense against malignancies. Read more

    In a new article, researchers describe investigations into an enigmatic group of coral-infecting microbes. Read more

    A new method for quantifying plant evolution reveals that after the onset of early seed plants, complexity halted for 250 million years until the diversification of flowering plants about 100 million years ago. Read more

    A team of engineers and chemists has taken a major step forward in the development of microbial fuel cells -- a technology that utilizes natural bacteria to extract electrons from organic matter in wastewater to generate electrical currents. Read more

    Findings from new research suggest that stormwater management may be less effective at decreasing urban runoff than is commonly assumed. Read more

    You can learn a lot about animals by simply watching them. But some secrets can only be revealed in the dark ... with an ultraviolet flashlight. Read more

    A team of researchers has developed a theory to explain how hydrodynamic electron flow could occur in 3D materials and observed it for the first time using a new imaging technique. Read more

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