Healers & Therapists News

Healers & Therapists News

Healers & Therapists News from June Meagher of AAMARHealing brings you the latest news from sources such as the BBC Health pages as well as the Green Med Info pages and Science Daily, we will be adding more news feeds shortly. Join the conversations on our LinkedIn group which has over 18,000 healers and therapists from around the globe and discover even more news and tips. If you have any news you would like to add to our website, please contact me and I can add it to our blog.


    • BBC News - Health
    • GreenMedInfo
    • Latest Science News -- ScienceDaily

    One in four hospitals sees long waits balloon, as NHS warned backlog will take years to tackle. Read more

    Hugely disappointing results mean ovarian-cancer screening remains more than a decade away. Read more

    Researchers are still analysing whether injecting two different vaccines leads to better protection. Read more

    The state will be "under the microscope", Boris Johnson says, as Labour urges an earlier start date. Read more

    Usually thought of as a party drug, a trial suggests it helps people with post-traumatic stress disorder. Read more

    Pregnant women will be directed to centres offering Pfizer and Moderna vaccines when booking. Read more

    An independent review calls the international response to the pandemic a "toxic cocktail". Read more

    Boris Johnson urges people to use common sense as he confirms the next stage of lockdown easing. Read more

    Grace Victory says she was given a 5% chance of recovery after contracting Covid during pregnancy. Read more

    People will be able to use the app for travel - but only if they have received two vaccine doses. Read more

    Pippa Stacey, 26, faces "all kinds of obstacles" as venues sprawl on to pavements. Read more

    The mayor of Greater Manchester says a "worrying" spike of cases in Bolton is a "cause of concern". Read more

    The Labour leader attacks Boris Johnson for "failing to act" in the 657 days since he promised to. Read more

    The Food and Drug Administration (FDA) calls it "a significant step" in the fight against Covid-19. Read more

    Stories of genuine experiences shared online have been followed by a wave of anti-vaccine disinformation. Read more

    Nurses in Italy have been instrumental in helping to fight Covid-19 - but it's taken a heavy toll. Read more

    In one of Africa's largest countries, people worry more about security and other diseases than Covid-19. Read more

    Coronavirus has affected many people in different ways - how would you react if someone needed support? Read more

    "Abhorrent" practices aimed at changing sexual orientation or gender identity will be banned, but not until further consultation. Read more

    When millions turned up for the Hindu festival amid a coronavirus surge, many feared the worst. Read more

    Volunteers are busting anti-vaccine conspiracy theories with decoy Facebook groups. Read more

    Explore the data on coronavirus in the UK and find out how many cases there are in your area. Read more

    Coronavirus is changing or mutating in ways that may help it spread better or resist existing vaccines. Read more

    Lockdown restrictions will ease in England, Scotland and Wales from Monday 17 May. Read more

    People aged 38 and 39 in England are now being offered a Covid vaccine as the rollout continues. Read more

    Secondary school pupils in England will no longer be required to wear them in class from next week. Read more

    Busting myths and explaining the facts around vaccines. Read more

    Shielding in England is ending on 31 March. Read more

    Why experts are concerned about the emergence of this particular new version of coronavirus. Read more

    What is it like to have the coronavirus, how will it affect you and how is it treated? Read more

    Some people across the UK have been able to form "support bubbles" or "extended households". Read more

    Everyone in England and Scotland is being encouraged to take rapid coronavirus tests regularly. Read more

    A new cough, fever and change in smell or taste are the key symptoms that mean you may have coronavirus. Read more

    Use our tool to check the meaning of key words and phrases associated with the Covid-19 outbreak. Read more

    While most people will have mild symptoms and recover quickly, some are more prone to getting sick. Read more

    With face masks in high demand, we look at whether they really can protect people from the virus. Read more

    When Paul Harvey's piano playing went viral, it inspired a donation of £1 million to charity. Read more

    The actress pays tribute to her mother Gloria, who died in a care home on Tuesday. Read more

    What happens when vaccines are slow to arrive - and what it means for ending lockdowns. Read more

    Bangladeshi men in the UK are being encouraged to talk about the effects the pandemic has had on them. Read more

    - greenmedinfo

    PMID:  Evid Based Complement Alternat Med. 2021 ;2021:6637612. Epub 2021 Jan 11. PMID: 33505498 Abstract Title:  The Impact of Tai Chi on Motor Function, Balance, and Quality of Life in Parkinson's Disease: A Systematic Review and Meta-Analysis. Abstract:  Objective: Parkinson's disease adversely affects function and quality of life, leading to increased mortality. The practice of Tai Chi has been associated with multifaceted improvements in health-related fitness. Considering the limited number of clinical studies included in previous reviews, inconsistent methodological quality, and inconclusive results, this meta-analysis aims to assess the effects of Tai Chi in patients with Parkinson's disease.Method: Four English language databases and four Chinese databases were systematically searched for existing randomized controlled trials (RCTs) of Tai Chi in Parkinson's disease from database inception through August 1, 2020. Methodological quality was appraised with the Cochrane Risk of Bias tool. A meta-analysis of comparative effects was performed using the Review Manager v.5.3 software.Results: Seventeen published RCTs totaling 951 subjects were included. Results showed that Tai Chi has a statistically significant effect on the outcomes of gait velocity, unified Parkinson's disease rating scale (UPDRS) motor score, activities-specific balance confidence (ABC) score, and Berg Balance Scale (BBS). The effects on the Timed Up… Read more

    - greenmedinfo

    PMID:  Front Endocrinol (Lausanne). 2020 ;11:543627. Epub 2021 Jan 19. PMID: 33542702 Abstract Title:  Effect of Tai Chi on Quality of Life, Body Mass Index, and Waist-Hip Ratio in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Abstract:  Background: Type 2 diabetes mellitus (T2DM) is a worldwide public health concern with high morbidity and various progressive diabetes complications that result in serious economic expenditure and social burden. This systematic review aims to evaluate the effect of Tai Chi on improving quality of life (QoL), body mass index (BMI) and waist-hip ratio (WHR) in patients with T2DM.Method: A systematic review and meta-analysis was performed following PRISMA recommendation. Four English databases and three Chinese databases were searched. The PEDro scale was used to assess the methodological quality of including studies. Study inclusion criteria: randomized controlled trials (RCTs) and quasi-experimental studies were included, patients with T2DM that adopted Tai Chi as intervention and QoL, BMI and/or WHR as outcome measurements.Results: Eighteen trials were included. The aggregated results of seven trials showed that Tai Chi statistically significantly improved QoL measured by the SF-36 on every domains (physical function: MD = 7.73, 95% confidence interval (CI) = 1.76 to 13.71, p =… Read more

    - greenmedinfo

    PMID:  PLoS One. 2021 ;16(2):e0246292. Epub 2021 Feb 4. PMID: 33539403 Abstract Title:  Tai Chi practitioners have lower fall risks under dual-task conditions during stair descending. Abstract:  Stairs are among the most hazardous locations, and stair descending contributes to a high risk of falls among the elderly under dual-task (DT) conditions. The purpose of this study was to determine whether the practitioners of Tai Chi (TC), one type of mind-body exercise, have lower fall risks under DT conditions during stair descending, compared with their no-exercise (NE) counterparts. Fifteen TC practitioners with at least 10 years of experience in TC and fifteen NE participants were recruited in this study. They were asked to descend a six-step staircase under single-task (ST) and DT conditions. An eight-camera motion analysis system and two force plates were used for data collection. Results showed group by DT interactions in walking velocity (p = 0.016) and center of mass-center of pressure inclination angle (COM-COP IA) in the anteroposterior directions (p = 0.026). Group effects observed with foot clearance (p = 0.031), trunk (p = 0.041) and head (p = 0.002) tilt angles, and COM-COP IA in the mediolateral (p = 0.006) directions. Significant DT effects only detected… Read more

    - greenmedinfo

    PMID:  BMJ Open Sport Exerc Med. 2021 ;7(1):e000817. Epub 2021 Feb 5. PMID: 33614126 Abstract Title:  Effect of Tai Chi on muscle strength, physical endurance, postural balance and flexibility: a systematic review and meta-analysis. Abstract:  Objective: To investigate the impact of Tai Chi training on muscle strength, physical endurance, postural balance and flexibility, as measured by tests commonly used in health-related fitness or competitive sports contexts.Design: Systematic review and meta-analysis.Data sources: The following databases were searched up to 31 July 2020: CINAHL, Cochrane Library, MEDLINE via PubMed and SPORTDiscus.Eligibility criteria for studies: Inclusion: (1) Randomised controlled trials published in German or English; (2) Tai Chi used as an intervention to improve physical performance; (3) Test methods commonly used in health-related fitness or competitive sports and (4) Participants aged≥16 years (irrespective of health status). Exclusion: (1) Studies not focusing on Tai Chi or including Tai Chi mixed with other interventions and (2) Modified or less than eight Tai Chi movements.Results: Out of 3817 records, 31 studies were included in the review, 21 of them in the meta-analysis. Significant improvements in handgrip strength (2.34 kg, 95% CI 1.53 to 3.14), walking distance during 6 min (43.37 m, 95% CI 29.12 to 57.63), standing time in single-leg-stance… Read more

    - GMI Research Group

    Achieving and maintaining a healthy weight may be tough, but these natural aids can help you lose unwanted pounds -- and keep them off for good Read more

    - GMI Research Group
    Maintain a Healthy Weight With These Natural Antiobesity Agents

    This article is copyrighted by GreenMedInfo LLC, 2021Visit our Re-post guidelines Achieving and maintaining a healthy weight may be tough, but these natural aids can help you lose unwanted pounds -- and keep them off for good Mother Nature is all about balance, but the pace of modern life can cause you to feel a bit tilted at times. If you are struggling with maintaining a healthy weight, or even if you have only a few pounds to lose, these six natural antiobesity agents can help you shift the scale into equilibrium. 1. Cinnamonread more Read more

    - greenmedinfo

    PMID:  PeerJ. 2020 ;8:e9232. Epub 2020 May 21. PMID: 32509470 Abstract Title:  Evaluation of the effective dose of amygdalin for the improvement of antioxidant gene expression and suppression of oxidative damage in mice. Abstract:  Background: Little is known regarding the toxic and therapeutic doses of amygdalin. Treatment regimens and schedules can vary between humans and animal models, and there have been reports of cyanide toxicity due to amygdalin use.Objective: The aim of this study was to evaluate the effect of different doses of amygdalin on antioxidant gene expression and suppression of oxidative damage in mice.Methods: Forty adult male mice were divided randomly into four groups (= 10) as follows and treated orally for two weeks: a control group treated with saline solution, a group treated with amygdalin at 200 mg/kg body weight, a group treated with amygdalin at 100 mg/kg body weight, and a group treated with amygdalin at 50 mg/kg body weight. Liver and testis samples were collected for gene expression, biochemical and histopathological analyses.Results: The mice treated with medium-dose amygdalin (100 mg/kg) showed upregulated mRNA expression of glutathione peroxidase (read more Read more

    - greenmedinfo

    PMID:  Curr Mol Pharmacol. 2020 Aug 10. Epub 2020 Aug 10. PMID: 32778045 Abstract Title:  Amygdalin decreases adhesion and migration of MDA-MB-231 and MCF-7 breast cancer cell lines. Abstract:  BACKGROUND: Cell adhesion as dynamic interactions between cell-cell and cell-matrix, has an essential role in cancer cell migration. Integrins as cell membrane receptors are involved in cell adhesion and signal transduction. Aberrant expression of integrins is associated with the cancer cell adhesion.OBJECTIVE: Targeting the process of cell adhesion and migration could be helpful to prevent cancer cell metastasis. Amygdalin is a cyanoglycoside compound with anti-cancer properties, while its effect on cancer cell adhesion is not completely clear.METHODS: The cytotoxic effect of amygdalin on breast cancer cell lines (MCF-7 and MDA-MB-231) and human skin fibroblast cell line as a normal cell, was evaluated through MTT assay. The cell adhesion assay and wound healing assay were performed to determine amygdalin effects on adhesion and migration of cancer cells. Further analysis was carried out to evaluate integrinα and β levels through real-time PCR.RESULTS: We demonstrated that amygdalin diminished the cell viability of both cell lines in a time and dose-dependent manner, while amygdalin did not have any toxicity on human skin fibroblast cell line… Read more

    - greenmedinfo

    PMID:  Saudi J Biol Sci. 2020 Sep ;27(9):2444-2451. Epub 2020 Jun 30. PMID: 32884428 Abstract Title:  In silico authentication of amygdalin as a potent anticancer compound in the bitter kernels of family Rosaceae. Abstract:  Amygdalin a naturally occurring compound, predominantly in the bitter kernels of apricot, almond, apple and other members of Rosaceae family. Though, amygdalin is used as an alternative therapy to treat various types of cancer but its role in cancer pathways has rarely been explored yet. Therefore, present study was intended with the aim to investigate the alleged anti-cancerous effects of amygdalin specifically on PI3K-AKT-mTOR and Ras pathways of cancer in human body. Computational modelling and simulation techniques were used to assess the effect of amygdalin on PI3K-AKT-mTOR and Ras pathways using different level of dosage. It was observed that amygdalin had direct and substantial contribution to regulate PI3K-mTOR activities on threshold levels while the other caner pathways were effected indirectly. Consequently, amygdalin is a down-regulator of a cancer within a specified amount and contribute considerably to reduce various types of cancer in human. Furthermore,andanalyses of amygdalin could be of helpful to authenticate its pharmacological effects. read more Read more

    - greenmedinfo

    PMID:  Stem Cells Int. 2020 ;2020:8811963. Epub 2020 Sep 7. PMID: 32963548 Abstract Title:  Amygdalin Promotes Fracture Healing through TGF-/Smad Signaling in Mesenchymal Stem Cells. Abstract:  Chondrogenesis and subsequent osteogenesis of mesenchymal stem cells (MSCs) and angiogenesis at injured sites are crucial for bone fracture healing. Amygdalin, a cyanogenic glycoside compound derived from bitter apricot kernel, has been reported to inhibit IL-1-induced chondrocyte degeneration and to stimulate blood circulation, suggesting a promising role of amygdalin in fracture healing. In this study, tibial fractures in C57BL/6 mice were treated with amygdalin. Fracture calluses were then harvested and subjected to radiographic, histological, and biomechanical testing, as well as angiography and gene expression analyses to evaluate fracture healing. The results showed that amygdalin treatment promoted bone fracture healing. Further experiments using MSC-specific transforming growth factor- (TGF-)receptor 2 conditional knockout (KO) mice () and C3H10 T1/2 murine mesenchymal progenitor cells showed that this effect was mediated through TGF-/Smad signaling. We conclude that amygdalin could be used as an alternative treatment for bone fractures. read more Read more

    - greenmedinfo

    PMID:  Biomed Pharmacother. 2018 Jul ;103:453-462. Epub 2018 Apr 24. PMID: 29674281 Abstract Title:  Effects of tocotrienol from Bixa orellana (annatto) on bone histomorphometry in a male osteoporosis model induced by buserelin. Abstract:  INTRODUCTION: Osteoporosis is a debilitating skeletal side effect of androgen deprivation therapy based on gonadotropin-releasing hormone (GnRH) agonist in men. Tocotrienol from Bixa orellana (annatto) has been demonstrated to offer protection against osteoporosis by exerting anabolic effects on bone. Thus, it may prevent osteoporosis among GnRH agonist users.OBJECTIVE: This study aimed to determine the effectiveness of annatto-tocotrienol on the bone turnover markers and bone histomorphometry in a model of male osteoporosis induced by buserelin (a GnRH agonist).METHODS: Forty-six three-months-old male Sprague-Dawley rats (three months old; 300-350 g) were randomly divided into six groups. The baseline control group (n = 6) was sacrificed at the onset of the study. The normal control group (n = 8) received corn oil (the vehicle of tocotrienol) orally daily and normal saline (the vehicle of buserelin) subcutaneously daily. The buserelin control (n = 8) received corn oil orally daily and subcutaneous buserelin injection 75 μg/kg/day daily. The calcium control (n = 8) received 1% calcium in drinking water and subcutaneous buserelin injection 75 μg/kg/day. The remaining rats were treated with two different treatments,… Read more

    - greenmedinfo

    PMID:  Evid Based Complement Alternat Med. 2018 ;2018:6091934. Epub 2018 Oct 2. PMID: 30369954 Abstract Title:  Hydroalcoholic Extract and Ethyl Acetate Fraction ofLeaves Decrease the Inflammatory Response toSubsp.. Abstract:  The incidence of infections caused by rapidly growing mycobacteria (RGM), especiallysubsp.(), is increasing worldwide. Severe infections are associated with abscess formation and strong inflammatory response. This study evaluated the antimicrobial and anti-inflammatory activities of a hydroalcoholic extract (BoHE) and ethyl acetate fraction (BoEA) ofleaves. Antimicrobial activity was evaluated by broth microdilution to determine the minimum inhibitory (MIC) and the minimum bactericidal (MBC) concentrations. Cytotoxicity was evaluated using erythrocytes and RAW 264.7 cells. Nitric oxide (NO) was assayed in stimulated RAW 264.7 cells, and inflammatory cell migration and acute toxicity were evaluated in a-induced peritonitis mouse model. The compounds present in BoEA were identified by high performance liquid chromatography and mass spectrometry (HPLC-MS). The MIC and MBC values were 2.34 mg/mL and 37.5 mg/mL for BoHE and 0.39 mg/mL and 6.25 mg/mL for BoEA. The extracts did not induce significant toxicity in erythrocytes and RAW 264.7 cells. High levels of NO induced bywere decreased by treatment with both extracts. The anti-inflammatory activity was confirmedby significant reduction of the cell migration to the… Read more

    - greenmedinfo

    PMID:  Int J Vitam Nutr Res. 2018 Feb ;88(1-2):16-26. Epub 2019 Mar 20. PMID: 30907699 Abstract Title:  Annatto ()δ-TCT supplementation protected against embryonic DNA damages through alterations in PI3K/ Akt-Cyclin D1 pathway. Abstract:  Protective action by annatto-derived delta-tocotrienol (δ-TCT) and soy-derived alpha-tocopherol (α-TOC) through the regulation of PI3K/Akt-Cyclin D1 pathway against the nicotine-induced DNA damages is the focus of the present study. Nicotine, which has been widely reported to have numerous adverse effects on the reproductive system, was used as reproductive toxicant. 48 female balb/c mice (6-8 weeks) (23-25 g) were randomly divided into 8 groups (G1-G8; n = 6) and treated with either nicotine or/and annatto δ-TCT/soy α-TOC for 7 consecutive days. On Day 8, the females were superovulated and mated before euthanized for embryo collection (46 hours post-coitum). Fifty 2-cell embryos from each group were used in gene expression analysis using Affymetrix QuantiGene Plex2.0 assay. Findings indicated that nicotine (G2) significantly decreased (pread more Read more

    - greenmedinfo

    PMID:  Gastroenterol Res Pract. 2019 ;2019:6963548. Epub 2019 Dec 1. PMID: 31885545 Abstract Title:  Effect of the Hydroethanolic Extract ofLinn (Bixaceae) Leaves on Castor Oil-Induced Diarrhea in Swiss Albino Mice. Abstract:  Objective: The treatment of diarrheal diseases is a serious problem in developing countries, where population generally uses medicinal plants. The leaves ofhave been reported to be traditionally used in the treatment of diarrhea by local people in the district of Khulna in Bangladesh. The aim of this study was to investigate the effects of the hydroethanolic extract ofleaves on castor oil-induced diarrhea in mice.Methods: The powder of the leaves ofwas macerated in ethanol/water mixture (20/80) for 48 hours and then filtered. The filtrate obtained was lyophilized, and the solutions to be administered to the animals were prepared. To induce diarrhea, animals orally received castor oil (1 mL/100 g bw). To determine the effective doses, each mouse received, 30 minutes after the administration of castor oil, one of the single oral doses of hydroethanolic extract ofleaves: 0, 25, 50, 100, and 200 mg/kg bw. The mass, number, and frequency of stool diarrhea were measured and recorded per hour for five hours. The effect of the hydroethanolic extract ofleaves on the intestinal transit was… Read more

    - greenmedinfo

    PMID:  Avicenna J Phytomed. 2020 Jul-Aug;10(4):428-439. PMID: 32850299 Abstract Title:  Anti-oxidant and anti-inflammatory potential of aqueous extracts of leaves, barks and roots ofL. (Bixaceae) on acetaminophen-induced liver damage in mice. Abstract:  Objective: is a plant from the Bixaceae family, for which, limited information is available on hepatoprotective properties. This study aimed at evaluating the protective effects of this plant on sub-acute acetaminophen (APAP)-induced liver injury in mice.Materials and Methods: Various aqueous extracts were prepared from roots, leaves, and barks. Albino mice were divided into six groups: a control group, an APAP group; a silymarin group (positive control) and three test groups. Mice were treated orally with APAP (250 mg/kg) followed 3 hr later by plant extracts, silymarin (50 mg/kg) or distilled water (10 ml/kg) administration once daily, for seven days. After treatment, animals were sacrificed, the liver was collected and different biochemical parameters were measured. Histological analyses were performed using hematoxylin/eosin staining and the qualitative phytochemical content of plant extracts was evaluated using conventional methods.Results: Administration ofbarks decoction (250 mg/kg) significantly reduced alanine aminotransferase levels (pread more Read more

    - greenmedinfo

    PMID:  Front Pharmacol. 2020 ;11:590929. Epub 2020 Oct 29. PMID: 33192531 Abstract Title:  Amygdalin Attenuates Atherosclerosis and Plays an Anti-Inflammatory Role in ApoE Knock-Out Mice and Bone Marrow-Derived Macrophages. Abstract:  Amygdalin, the main component of Prunus persica (L.) Stokes, has been used to treat atherosclerosis in mouse model due to its anti-inflammatory role. However, the underlying mechanism remains poorly understood. This study aimed to evidence the influence of amygdalin on high-fat diet-induced atherosclerosis in ApoE knock-out (ApoE) mice, and unravel its anti-inflammatory mechanism. ApoEmice fed with high-fat diet for eight weeks were randomly divided into four groups and injected with amygdalin at the concentration of 0.08 or 0.04 mg/kg for 12 weeks. Additionally, bone marrow-derived macrophages were intervened with oxidized low-density lipoprotein (oxLDL) or lipopolysaccharide plus various concentrations of amygdalin for further exploration. Body weight, serum lipid profiles and inflammatory cytokines were detected by ELISA, gene expression by RT-PCR, plaque sizes by Oil Red O, lymphatic vessels of heart atrium and Tnfα production by immunofluorescence staining. MAPKs, AP-1 and NF-κB p65 pathways were also explored. Amygdalin decreased body weight, serum lipids, plaque size, lymphatic vessels and inflammatory cytokines (Il-6, Tnfα), Nos1 and Nos2, and increased Il-10 expression in ApoEmice. In oxLDL-induced bone… Read more

    - greenmedinfo

    PMID:  Life Sci. 2021 Jan 15 ;265:118835. Epub 2020 Nov 28. PMID: 33253723 Abstract Title:  Amygdalin alleviates renal injury by suppressing inflammation, oxidative stress and fibrosis in streptozotocin-induced diabetic rats. Abstract:  AIMS: To explore the protective efficacies and potent mechanism of amygdalin on high glucose-cultured renal cell HBZY-1 in vitro and streptozotocin (STZ)-induced diabetic nephropathy (DN) rat in vivo.MAIN METHODS: The cellar proliferation and generation of ROS in high-glucose cultured HBZY-1 cell were assessed by MTT and DCFH-DA assay, respectively. The fasting blood glucose levels, renal function and inflammation indexes as well as oxidative stress markers in STZ-induced diabetic rats were all measured. The histologic renal section was stained with Mason and periodic acid-Schiff (PAS) method. Immunohistochemistry and western blotting methods were applied to assess expression levels of extracellular matrix (ECM), epithelial-mesenchymal transition (EMT)-related as well as TGF-β1/Smad signaling pathway-related proteins.KEY FINDINGS: Firstly, amygdalin significantly suppressed the excessive cell proliferation and ROS generation in HBZY-1 cells cultured with high glucose. The hyperglycemia, 24 h-UP excretion, BUN and Scr of DN rats were significantly attenuated after the chronic treatment of amygdalin. Moreover, MDA, SOD, IFN-γ and IL-12 levels in kidney tissues were all effectively reduced. Besides, amygdalin can suppress the ECM accumulation… Read more

    - greenmedinfo

    PMID:  Int Immunopharmacol. 2021 Jan ;90:107151. Epub 2020 Dec 6. PMID: 33296784 Abstract Title:  Amygdalin inhibits TGFβ1-induced activation of hepatic stellate cells (HSCs) in vitro and CCl-induced hepatic fibrosis in rats in vivo. Abstract:  The activation of hepatic stellate cells (HSCs) has been considered one of the major events in hepatic fibrosis. Amygdalin has been used to treat cancers and alleviate pain; however, its role and mechanism in HSC activation and hepatic fibrosis remain unclear. In the present study, transforming growth factor-beta 1 (TGF-β1) stimulated the activation of HSCs, as indicated by significantly increased alpha-smooth muscle actin (α-SMA), desmin, collagen I, and tissue inhibitor of metalloproteinase-1 (TIMP-1) protein levels. Amygdalin treatment dramatically suppressed TGF-β1-induced HSC proliferation and activation. Moreover, amygdalin treatment also reduced the TGF-β1-induced secretion of cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), platelet-derived growth factor (PDGF), and chemokine (C-C motif) ligand 2 (CCL2), as well as the phosphorylation of Smad2, Smad3, and p65. In the CCl-stimulated liver fibrosis rat model, amygdalin treatment improved liver fibrosis and liver damage by reducing focal necrosis, collagen fiber accumulation, and the protein levels ofα-SMA, desmin, collagen I, and TIMP-1 in hepatic tissue samples and reducing serum alanine transaminase (ALT) and… Read more

    - greenmedinfo

    PMID:  BMC Infect Dis. 2021 Jan 12 ;21(1):56. Epub 2021 Jan 12. PMID: 33435880 Abstract Title:  Amygdalin promotes the activity of T cells to suppress the progression of HBV-related hepatocellular carcinoma via the JAK2/STAT3 signaling pathway. Abstract:  BACKGROUND: Hepatitis B virus (HBV) infection is a high-risk factor of hepatocellular carcinoma (HCC). Cellular immune responses are essential for HCC development, and the CD4+ and CD8+ T subtypes are identified as the primary anti-tumor immune cells. In the study, we investigated the effect and mechanism of amygdalin in the cellular immune response in HBV-related HCC and HCC progression.METHODS: The cell proliferation was examined by MTT analysis. Cells metastasis ability was detected by Invasion and migration assays. Quantification of apoptotic cells was performed with Flow cytometer assay. The protein levels of p-STAT3, STAT3, p-JAK2, JAK2, caspase-3, cleaved caspase-3 were detected by performing immunoblotting assays.RESULTS: We demonstrate that amygdalin treatment could rescue the HBV-T cell viability and IFN-γ and TNF-αproduction. In HBV-T cells, the MFI levels of CD8are lower than that in NC-T cells. Moreover, the phosphorylation levels of STAT3 and JAK2 are higher in HBV-T cells, compared to those in NC-T cells, and then reduced by amygdalin treatment. Co-culture with HBV-T cells could… Read more

    - greenmedinfo

    PMID:  Environ Toxicol. 2021 May ;36(5):926-934. Epub 2021 Jan 15. PMID: 33448586 Abstract Title:  Cardioprotective potential of amygdalin against angiotensin II induced cardiac hypertrophy, oxidative stress and inflammatory responses through modulation of Nrf2 and NF-κB activation. Abstract:  Heart failure (HF) and cardiac hypertrophy is an unfavorable outcome of pathological cardiac remodeling and represents the most important contributing factor for HF and cardiac hypertrophy. Amygdalin (AMG) is a cyanogenic glycoside derived from bitter almonds. Accumulating evidences have highlighted their pharmacological potentials against various diseases. However, there is no report delineating the potential of AMG against angiotensin (Ang II) induced cardiac injuries. Thus, the present study was performed to explore whether AMG could ameliorate Ang II induced cardiomyopathies and thereby ascertain the underlying mechanisms thereof. To this end, H9c2 cells were treated with Ang II and thereafter treated with various concentration of AMG and finally the cardio-protective effects of AMG were analyzed through Western blotting, immunofluorescence, and insilico analysis. Our results showed that the cardiomyocyte cell size, inflammatory markers and cytokines(pNF-κB, TNF-α, iNOS and COX-2) were markedly increased following Ang II treatment; nevertheless, treatment with AMG led to considerable decrement in the Ang II induced enlargement of the cardiomyocytes, and attenuate the… Read more

    - greenmedinfo

    PMID:  J Med Food. 2021 Mar 17. Epub 2021 Mar 17. PMID: 33733877 Abstract Title:  The Combination of Amygdalin with Some Anticancer, Antiparasitic, and Antigout Drugs Against MG63, Saos2, SW1353, and FL Cells. Abstract:  Osteosarcoma has a poor prognosis and survival rate due to inadequate chemotherapy, high recurrence ability, high metastasis potential, and almost no radiotherapy being applied. One of the strategies to solve these problems is to develop the pharmacologically active plant metabolite, amygdalin, in combination therapeutic systems. In this project, the antiproliferative effects of amygdalin alone and in binary or ternary combinations with some anticancer drugs (cisplatin, 5-fluorouracil, oxaliplatin, and camptothecin), antiparasitic drugs (metronidazole and miltefosine), and an antigout drug (colchicine) were examined using human bone osteosarcoma cell lines (MG-63 and Saos2), the chondrosarcoma cell line (SW1353), and the normal human cell line (FL). Known half-maximal inhibitory concentration values of the drugs were taken into consideration, and the recommended combination ratios were used in the Chou-Talalay method. The strong synergistic effect commonly seen in the combination of amygdalin with miltefosine, metronidazole, camptothecin, colchicine, oxaliplatin, 5-fluorouracil, and cisplatin dual drug indicates that these combinations can be used in cancer treatment. The synergistic effect caused by amygdalin decreases toxicity by… Read more

    - greenmedinfo

    PMID:  Oxid Med Cell Longev. 2020 ;2020:8858578. Epub 2020 Dec 28. PMID: 33456677 Abstract Title:  Antioxidant and-Glucosidase Inhibitory Activities Guided Isolation and Identification of Components from Mango Seed Kernel. Abstract:  In the present study, petroleum ether, dichloromethane, ethyl acetate, and-butanol fractions of mango seed kernel exhibited different degrees of antioxidant and-glucosidase inhibitory activity. Thus, quantitative and qualitative analysis of the petroleum ether fraction was conducted by GC-MS. Among identified components, four unsaturated fatty acids had never been reported in natural products before, together with 19 known components. In addition, 17 compounds were isolated and elucidated from other active fractions. Compounds,,, andwere isolated for the first time fromgenus. Compoundsandexhibited prominent DPPH radical scavenging and-glucosidase inhibitory effects. In order to further explore their mechanism of-glucosidase inhibition, their enzyme kinetics and in silico modeling experiments were performed. The results indicated thatinhibited-glucosidase in a noncompetitive manner, whereasacted in a competitive manner. In molecular docking, the stability of binding was enhanced by-T-shaped,-alkyl,-stacked, hydrogen bond, and electrostatic interactions. Thus, compoundsandwere determined to be new potent antioxidant and-glucosidase inhibitors for preventing food oxidation and enhancing hypoglycemic activity. read more Read more

    - greenmedinfo

    PMID:  Mol Med Rep. 2021 Jun ;23(6). Epub 2021 Apr 26. PMID: 33899114 Abstract Title:  Mangiferin inhibits cell migration and angiogenesis via PI3K/AKT/mTOR signaling in high glucose‑ and hypoxia‑induced RRCECs. Abstract:  Mangiferin is a prominent active component that can be derived from several traditional herbs, includingL.,Bge., and (L.) DC., which displays antidiabetic properties. Diabetic retinopathy (DR), a serious complication caused by diabetes, is the leading cause of blindness. The present study aimed to evaluate the beneficial effects of mangiferin on high glucose (HG)/hypoxia‑induced rat retinal capillary endothelial cell (RRCEC) angiogenesis, as well as the underlying mechanisms. To establish anmodel of DR, RRCECs were exposed to 30 mM glucose and hypoxia. Following treatment with different doses of mangiferin (0.05, 0.1 or 0.2 M), RRCEC viability, migration and angiogenesis were assessed by performing Cell Counting Kit 8, immunofluorescence, wound healing, Transwell and tube formation assays. Western blotting was conducted to evaluate protein expression levels. Furthermore, LY294002 and IGF‑1, an inhibitor and activator of the PI3K/AKT/mTOR signaling pathway, respectively, were used to verify the potential mechanisms underlying mangiferin. The results demonstrated that mangiferin notably inhibited HG/hypoxia‑induced RRCEC migration and angiogenesis. HG/hypoxia‑induced upregulation of hypoxia‑inducible factor‑1α, vascular endothelial growth factor, matrix metallopeptidase (MMP)2 and MMP9 expression levels and the phosphorylation of… Read more

    - greenmedinfo

    n/a PMID:  Plants (Basel). 2021 Apr 21 ;10(5). Epub 2021 Apr 21. PMID: 33919084 Abstract Title:  Anti-Arthritic and Anti-Inflammatory Potential ofExtract Fractions: An In Silico, In Vitro and In Vivo Approach. Abstract:  The fruits ofhave traditionally been used for the management of rheumatism in the northeast region of India. The present study explores the probable anti-arthritis and anti-inflammatory potential offruit extract's ethanolic fraction (EtoH-F). To support this study, we first approached the parameters in silico by means of the active constituents of the plant (beta amyrin, beta sitosterol, oleonolic acid and co-crystallised ligands, i.e., SPD-304) via molecular docking on COX-1, COX-2 and TNF-α. Thereafter, the absorption, distribution, metabolism, excretion and toxicity properties were also determined, and finally experimental activity was performed in vitro and in vivo. The in vitro activities of the plant extract fractions were evaluated by means of parameters like 1,1-Diphenyl-2- picrylhydrazyl (DPPH), free radical-reducing potential, albumin denaturation, and protease inhibitory activity. The in vivo activity was evaluated using parameters like COX, TNF-α and IL-6 inhibition assay and arthritis score in Freund Adjuvant (CFA) models at a dose of 400 mg/kg b.w. per day of different fractions (hexane, chloroform, alcoholic). The molecular docking assay was performed on COX-1,… Read more

    - greenmedinfo

    PMID:  Biochem Biophys Res Commun. 2009 Dec 25 ;390(4):1372-6. Epub 2009 Nov 3. PMID: 19891958 Abstract Title:  Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation. Abstract:  Insulin resistance is partly due to suppression of insulin-induced glucose uptake into adipocytes. The uptake is dependent on adipocyte differentiation, which is controlled at mRNA transcription level. The peroxisome proliferator-activated receptor (PPAR), a ligand-regulated nuclear receptor, is involved in the differentiation. Many food-derived compounds serve as ligands to activate or inactivate PPAR. In this study, we demonstrated that bixin and norbixin (annatto extracts) activate PPARgamma by luciferase reporter assay using GAL4-PPAR chimera proteins. To examine the effects of bixin on adipocytes, 3T3-L1 adipocytes were treated with bixin or norbixin. The treatment induced mRNA expression of PPARgamma target genes such as adipocyte-specific fatty acid-binding protein (aP2), lipoprotein lipase (LPL), and adiponectin in differentiated 3T3-L1 adipocytes and enhanced insulin-dependent glucose uptake. The observations indicate that bixin acts as an agonist of PPARgamma and enhances insulin sensitivity in 3T3-L1 adipocytes, suggesting that bixin is a valuable food-derived compound as a PPAR ligand to regulate lipid metabolism and to ameliorate metabolic syndrome. read more Read more

    - greenmedinfo

    PMID:  J Agric Food Chem. 2012 Dec 5 ;60(48):11952-8. Epub 2012 Nov 21. PMID: 23145898 Abstract Title:  Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice. Abstract:  Peroxisome proliferator-activated receptorα (PPARα) is a ligand-activated transcription factor that regulates the expression of the genes involved in fatty acid oxidation. PPARα activators induce fatty acid oxidation in the liver, thereby improving lipid and carbohydrate metabolism in obese mice. In this study, the dietary cis-carotenoids bixin and norbixin, which are commonly used in the food coloring industry, were found to activate PPARα by luciferase reporter assays using GAL4/PPARα chimeric and full-length PPARα systems. Treatment with bixin and norbixin induced the mRNA expression of PPARα target genes involved in fatty acid oxidation in PPARα-expressing HepG2 hepatocytes. In obese KK-Ay mice, bixin treatment suppressed the development of hyperlipidemia and hepatic lipid accumulation. In the livers of bixin-treated mice, the mRNA levels of PPARα target genes related to fatty acid oxidation were up-regulated. Moreover, bixin treatment also improved obesity-induced dysfunctions of carbohydrate metabolism, such as hyperglycemia, hyperinsulinemia, and hypoadiponectinemia. Glucose tolerance test and insulin tolerance test revealed that glucose intolerance and insulin resistance in KK-Ay obese mice were attenuatedby the treatment… Read more

    - greenmedinfo

    PMID:  Curr Pharm Biotechnol. 2013 ;14(9):785-91. PMID: 24372269 Abstract Title:  Bixin action in the healing process of rats mouth wounds. Abstract:  Oral lesions that manifest as ulcer lesions are quite common and can cause discomfort to the patient. Searching for drugs to accelerate the healing of these lesions is nonstop process. Bixin is a molecule found in annatto (urucum) seeds and is considered a viable therapeutic option to treat such lesions due to its anti-inflammatory, anti-oxidant, and healing properties. Therefore, the present study aimed to evaluate the effect of the bixin solution in the ulcer healing process in the oral mucosa of rats. Ulcers were induced with punches of 0.5 cm in the middle of the dorsum of the tongue of 64 Wistar rats. The animals were randomly divided into 8 groups, in which 4 groups were treated with saline solution, while the other 4 were treated with the bixin solution. The animals were sacrificed in the periods 2, 7, 14, and 21 days after the beginning of the treatment. The species were histologically processed and stained with hematoxylin/eosin and picrosirius. Fibroblasts, reepithelialization, and wound contraction could be observed, as could the quantification of neutrophils, macrophages, plasma cells, lymphocytes, and… Read more

    - greenmedinfo

    PMID:  Int J Pharm. 2014 Oct 1 ;473(1-2):485-92. Epub 2014 Jul 24. PMID: 25066077 Abstract Title:  Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation. Abstract:  In the present study, a natural antioxidant drug, bixin was loaded into solid lipid nanoparticles using trimyristin and glycerol monostearate as different lipid matrices and soya and egg lecithin as stabilizers. Developed bixin SLNs were characterized including in vitro drug release and in vivo evaluation of hepatoprotective activity using Wistar rats. Bixin SLNs were prepared by hot homogenisation followed by ultrasonication technique. The particle size ranged from 135.5-352.8 nm with PDI 0.185-0.572. Zeta potential of bixin SLNs was -17.9 to -36.5 mV. Bixin was successfully incorporated into SLNs with entrapment efficiency above 99% and loading efficiency maximum 17.96%. There was no interaction of bixin with selected lipids TM and GMS, confirmed by FTIR studies. DSC studies revealed that preparation method did not change crystallinity of bixin and TM whereas GMS crystallinity was reduced. In vitro drug release studies in Sorensen buffer, pH 7.7 exhibited initial burst effect followed by a sustained release of bixin. Drug release kinetic studies showed that the release was first order diffusion controlled and the n-values… Read more

    - greenmedinfo

    PMID:  Biol Res. 2014 Sep 29 ;47:49. Epub 2014 Sep 29. PMID: 25299839 Abstract Title:  Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats. Abstract:  BACKGROUND: The liver is an important organ for its ability to transform xenobiotics, making the liver tissue a prime target for toxic substances. The carotenoid bixin present in annatto is an antioxidant that can protect cells and tissues against the deleterious effects of free radicals. In this study, we evaluated the protective effect of bixin on liver damage induced by carbon tetrachloride (CCl4) in rats.RESULTS: The animals were divided into four groups with six rats in each group. CCl4 (0.125 mL kg(-1) body wt.) was injected intraperitoneally, and bixin (5.0 mg kg(-1) body wt.) was given by gavage 7 days before the CCl4 injection. Bixin prevented the liver damage caused by CCl4, as noted by the significant decrease in serum aminotransferases release. Bixin protected the liver against the oxidizing effects of CCl4 by preventing a decrease in glutathione reductase activity and the levels of reduced glutathione and NADPH. The peroxidation of membrane lipids and histopathological damage of the liver was significantly prevented by bixin treatment.CONCLUSION: Therefore, we can conclude that the protective effect of… Read more

    - greenmedinfo

    PMID:  Mol Cell Biochem. 2015 May ;403(1-2):243-53. Epub 2015 Feb 22. PMID: 25702177 Abstract Title:  The antiatherogenic effect of bixin in hypercholesterolemic rabbits is associated to the improvement of lipid profile and to its antioxidant and anti-inflammatory effects. Abstract:  Hypercholesterolemia and oxidative stress have been implicated in the pathophysiology of atherosclerosis and coronary artery disease. We investigated whether the carotenoid bixin (BIX) may reduce oxidative damage, inflammatory response, and the atherosclerotic lesion induced by hypercholesterolemia in rabbits. Rabbits received regular chow (control) or a hypercholesterolemic diet (0.5% cholesterol) alone or supplemented with BIX (10, 30 or 100 mg/kg body weight, b.w.) or simvastatin (15 mg/kg b.w.) for 60 days. Treatment with BIX or simvastatin reduced the atherosclerotic lesions in cholesterol-fed rabbits (up to 55 and 96% reduction, respectively). This protective effect of BIX was accompanied by decrease in the levels of tumor necrosis factor alpha by 15%, interleukin 6 by 19%, lipid peroxidation by 60%, non-high-density lipoprotein cholesterol (non-HDL-C) by 37%, and triglycerides by 41%. BIX increased by 160% the HDL-C levels and decreased by 67% the atherogenic index of hypercholesterolemic rabbits. In atherosclerotic rabbits, the non-protein thiol groups content and the activity of the antioxidant enzymes superoxide dismutase, catalase,… Read more

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