Healers & Therapists News

Healers & Therapists News from June Meagher of AAMARHealing brings you the latest news from sources such as the BBC Health pages as well as the Green Med Info pages and Science Daily, we will be adding more news feeds shortly. Join the conversations on our LinkedIn group which has over 18,000 healers and therapists from around the globe and discover even more news and tips. If you have any news you would like to add to our website, please contact me and I can add it to our blog.

 

    • BBC News - Health
    • GreenMedInfo
    • Latest Science News -- ScienceDaily

    One family in London say they received scores of long, repetitive calls from contact tracers. Read more

    The aim is to help people travelling to destinations where a negative result is required on arrival. Read more

    People in Wales told to stay home from Friday, with pubs and restaurants ordered to close. Read more

    Fourteen new donation centres are to open around the country in November and December. Read more

    A decision on local rules and financial support must be made "one way or another", a minister says. Read more

    Far more people are dying at home in England and Wales than normal from heart disease and dementia. Read more

    Why does the divergence between science and politics appear to be wider than it has ever been? Read more

    The figures come as NI's schools face a two-week closure aimed at curbing the spread of coronavirus. Read more

    The condition, which causes severe pain and heavy periods, takes eight years on average to be diagnosed. Read more

    Swimmers at a London lido aid understanding of what cold does to the body. Read more

    Patients admitted to intensive care have a better chance of surviving now than they did in the first wave. Read more

    The R number has crept up to 1.3-1.5, with growth of the epidemic still widespread. Read more

    Areas where transmission is highest in England are shutting gyms, but does the science support it? Read more

    With so many different soaps to choose from, Dr Michelle Wong explains how to find the best soap for you. Read more

    The government did not take the recommendation of a "circuit breaker" lockdown. Read more

    Could the long-term mental health impact of virus restrictions be far more damaging than the virus itself? Read more

    Sage and Prof Chris Whitty appear at odds with the political decisions made by government. Read more

    Bats have been scapegoated by humans for centuries, with Covid only the latest example, say scientists. Read more

    Boris Johnson says there are eight hospitals under way and 40 more to come. Read more

    The latest survey from the Born in Bradford study shows the effect of lockdown on family finances and mental health. Read more

    Why is coronavirus leaving some people with long-term health problems including fatigue? Read more

    One in four people in the UK is currently subject to local interventions to prevent the spread of Covid. Read more

    Partners are still not able to attend terminations at most hospitals amid coronavirus restrictions. Read more

    The US president has multiple risk factors for developing a severe form of Covid-19, so what does it mean? Read more

    Dr John Wright looks at the kit installed in a Bradford mosque in the hope of limiting the spread of Covid-19. Read more

    With similar symptoms, deciding whether or not you need to get tested for coronavirus can be tricky. Read more

    We examine government claims on testing capacity, international comparisons and the average distance travelled to a test centre. Read more

    A Kenyan doctor is calling for change in NHS policies to help more black people give blood. Read more

    If scientists succeed in making a coronavirus vaccine, when will we get it, how much will it cost and who will get it first? Read more

    Parents are missing work and children kept home from school as they wrestle with the testing system Read more

    Changes in all our lives have increased anxiety levels but there is support and advice available. Read more

    Corby has the fifth highest rate of new cases per 100,000 people in English towns and cities. Read more

    Some people might want to consider it during the pandemic. Here's why. Read more

    For some people Covid just will not go away. One woman who thinks she had it has made an Instagram diary. Read more

    A phenomenon called parosmia has left coronavirus survivors trapped in a world of distorted scents. Read more

    Drive-through clinics and extra staff could boost England's biggest flu vaccination programme. Read more

    Charities say thousands who have been shielding may have to choose between a job and their health. Read more

    New parents call on the government for extra support and extended leave due to the pandemic. Read more

    Why fridges, vials and polling stations could be key in the distribution of a coronavirus vaccine. Read more

    Explore the data on coronavirus in the UK and find out how many cases there are in your area. Read more

    - greenmedinfo

    PMID:  World Neurosurg. 2019 Oct ;130:400-404. Epub 2019 Jul 18. PMID: 31326640 Abstract Title:  Spontaneous Tumor Regression of Intracranial Solitary Fibrous Tumor Originating From the Medulla Oblongata: A Case Report and Literature Review. Abstract:  BACKGROUND: Intracranial solitary fibrous tumor (SFT) is a rare occurrence and involvement of the fourth ventricle rarely reported. Because of its rarity, some characteristics of intracranial SFT seem to still remain uncertain.CASE DESCRIPTION: This study describes a very rare case of intracranial SFT in a 55-year-old woman who presented with gait disturbance and numbness in bilateral upper limbs from 3 months before visiting the hospital. Head magnetic resonance imaging scan revealed a homogeneously enhancing mass lesion located primarily in the fourth ventricle extending into the spinal canal and left foramen of Luschka, with a maximum diameter of 60 mm. Notably, this tumor presented spontaneous partial regression during waiting planned surgery without therapy, including chemotherapy and radiotherapy. This patient underwent a midline suboccipital craniotomy and resection of the tumor. Interestingly, there was no attachment to the dura mater of the posterior cranial fossa and the lesion was only attached to the dorsal part of the medulla oblongata.CONCLUSIONS: Although the location of the SFT in the fourth ventricle… Read more

    - greenmedinfo

    PMID:  Pol J Pathol. 2019 ;70(2):139-143. PMID: 31556565 Abstract Title:  Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis. Abstract:  We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy of the primary tumour demonstrated a dense stromal infiltrate of CD8+/granzyme B+ activated cytotoxic T-cells suggestive of a robust antitumour immune response. Paradoxically, both tumour cells and tumour infiltrating immune cells demonstrated a diffuse PD-L1 expression, revealing that antitumour immune response has the ability to spontaneously overcome inhibitory mechanisms induced by cancerous growth. read more Read more

    - greenmedinfo

    PMID:  Clin Nucl Med. 2020 Feb ;45(2):e88-e91. PMID: 31652159 Abstract Title:  Complete Spontaneous Regression of Hepatosplenic T-Cell Lymphoma After Surgical Biopsy. Abstract:  F-FDG PET/CT for a 74-year-old man with elevated serum soluble interleukin 2 receptor showed multiple intense uptake in the liver, spleen, and bone. A surgical biopsy from 2 of liver tumors confirmed hepatosplenicαβ T-cell lymphoma. One and a half months after biopsy, FDG PET scan was performed again for staging before starting chemotherapy, and it showed the complete disappearance of all of the lesions. The excisional biopsy could be a possible trigger of his spontaneous regression. read more Read more

    - greenmedinfo

    PMID:  Acta Neurochir (Wien). 2020 02 ;162(2):433-436. Epub 2019 Nov 12. PMID: 31713157 Abstract Title:  Spontaneous regression of a clival chordoma. Case report. Abstract:  In this case report, we present a rare and previously unreported case of spontaneous regression of a histologically consistent clival chordoma. At the time of diagnosis, imaging demonstrated a T2 hyperintense and T1 isointense midline skull base mass, centered in the nasopharynx, with scalloping of the ventral clivus consistent with a chordoma measuring 3.1× 1.9 × 3.0 cm (8.84 cm). On pre-operative imaging 2 months later, with no intervening therapy, the mass had regressed by 61.7% to a size of 2.3× 2.1 × 1.4 cm (3.38 cm). The patient self-administered several herbal supplements and animal oils which may have contributed to tumor regression. The purpose of this report is to document this rare occurrence and provide a comprehensive description of the case details and list of the various medications, herbs, and supplements used prior to this rare event. read more Read more

    - greenmedinfo

    PMID:  Blood. 2020 02 6 ;135(6):411-428. PMID: 31794600 Abstract Title:  Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL. Abstract:  Spontaneous regression is a recognized phenomenon in chronic lymphocytic leukemia (CLL) but its biological basis remains unknown. We undertook a detailed investigation of the biological and clinical features of 20 spontaneous CLL regression cases incorporating phenotypic, functional, transcriptomic, and genomic studies at sequential time points. All spontaneously regressed tumors were IGHV-mutated with no restricted IGHV usage or B-cell receptor (BCR) stereotypy. They exhibited shortened telomeres similar to nonregressing CLL, indicating prior proliferation. They also displayed low Ki-67, CD49d, cell-surface immunoglobulin M (IgM) expression and IgM-signaling response but high CXCR4 expression, indicating low proliferative activity associated with poor migration to proliferation centers, with these features becoming increasingly marked during regression. Spontaneously regressed CLL displayed a transcriptome profile characterized by downregulation of metabolic processes as well as MYC and its downstream targets compared with nonregressing CLL. Moreover, spontaneous regression was associated with reversal of T-cell exhaustion features including reduced programmed cell death 1 expression and increased T-cell proliferation. Interestingly, archetypal CLL genomic aberrations including HIST1H1B and TP53 mutations and del(13q14) were found in some spontaneously regressing tumors, but… Read more

    - greenmedinfo

    PMID:  Rinsho Ketsueki. 2019 ;60(11):1573-1576. PMID: 31839637 Abstract Title:  [Spontaneous regression of primary gastric EBV-positive diffuse large B-cell lymphoma]. Abstract:  Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) in the elderly was revised from the category EBV-positive DLBCL not otherwise specified in WHO 2017. The prognosis of this lymphoma is very poor. We report a case of an 82-year-old woman diagnosed with gastric EBV-positive DLBCL (WHO 2008). Gastroduodenoscopy revealed multiple ulcers and fold thickening. She was followed-up without any treatment because of her old age. Repeat endoscopy one year and eight months later revealed a single ulcer with no lymphoma cells found in a biopsy specimen. Two years later, the lesion had spontaneously disappeared. read more Read more

    - greenmedinfo

    PMID:  BMJ Case Rep. 2020 Feb 10 ;13(2). Epub 2020 Feb 10. PMID: 32047089 Abstract Title:  Spontaneous regression of hepatocellular carcinoma: myth or reality? Abstract:  We present a case of a 68-year-old man with chronic hepatitis C infection, with no evidence of chronic liver disease during the first years of follow-up, diagnosed with a hepatocellular carcinoma (HCC) with 40 mm (α-fetoprotein (AFP) 205 ng/mL). He underwent segmental liver resection and pathology analysis was consistent with HCC and cirrhosis in the adjacent liver. Four months after surgery, AFP raised up to 126 661 ng/mL and abdominal MRI revealed a multinodular HCC. Patient rejected treatmentwith sorafenib and started megestrol and an herbal medicine, soursop (). Six months later, AFP markedly decreased (28 ng/mL) and abdominal MRI showed decreasing size and number of lesions. At 5 years of follow-up, he has no evidence of HCC. Spontaneous regression of HCC is a rare condition and the underlying mechanism is unclear. In this case there is a temporal relation between the start of megestrol andand HCC regression. read more Read more

    - greenmedinfo

    PMID:  Cureus. 2020 Jan 12 ;12(1):e6639. Epub 2020 Jan 12. PMID: 32064211 Abstract Title:  Spontaneous Regression of Non-small Cell Lung Cancer: A Case Report and Literature Review. Abstract:  Spontaneous cancer regression is rare, and particularly rare for non-small cell lung cancer (NSCLC). The pathogenesis of spontaneous regressions is poorly understood, but of interest to many patients and providers. The infrequency of spontaneous regression makes it a challenging phenomenon to understand and study. We present a case of biopsy-proven NSCLC in a 73-year-old man that regressed without treatment. read more Read more

    - greenmedinfo

    PMID:  Gan To Kagaku Ryoho. 2019 Dec ;46(13):2568-2570. PMID: 32157001 Abstract Title:  [Spontaneous Disappearance of Undifferentiated Pleomorphic Primary Mesenteric Sarcoma-A Case Report]. Abstract:  The patient was a 49-year-old man with persistent fever since the introduction of hemodialysis(HD). Vomiting and abdominal swelling appeared 4 months after initiating hemodialysis. Computed tomography(CT)scan revealed a tumor measuring 9 cm, and disorders of passage from the jejunum. Surgery was performed, and resection was impossible because of peritoneal dissemination. Histopathological examination of the disseminated nodes suggested an undifferentiated pleomorphic sarcoma. Postoperatively, drainage from the gastric fistula was approximately 2,000mL/day. Chemotherapy was considered impossible because of HD, and palliative therapy was selected. However, the volume of drainage from the gastric fistula gradually decreased, and the disorders of passage reduced. CT scan confirmed marked reduction in the size of the intraperitoneal tumor and its subsequent disappearance. At the 2-year-and-5-month postoperative follow-up, no relapses were observed, and the course had been uneventful. Undifferentiated pleomorphic sarcomas develop in the soft tissue of adults and have a poor prognosis. However, mesenteric development is rare. Total tumorectomy is the first choice of treatment. A consensus on the usefulness of chemotherapy or radiotherapy has not been reached. Furthermore, no studies have reported spontaneous… Read more

    - greenmedinfo

    PMID:  J Cutan Pathol. 2020 Mar 28. Epub 2020 Mar 28. PMID: 32222990 Abstract Title:  Cytotoxic-mediated spontaneous regression of inflammatory cutaneous metastases of breast carcinoma. Abstract:  Spontaneous regression (SR) of cancer is a rare but well-documented biological phenomenon, which is even rarer in the context of metastatic breast carcinoma. Different mechanisms of SR are still under debate, including immune-mediated response. We herein report a case of the SR of intralymphatic cutaneous metastases of a breast carcinoma with spontaneously-induced T-cell-mediated cytotoxic response. An 86-year-old female was diagnosed with locally advanced right breast carcinoma and axillary lymph node metastases, without distant metastases The patient refused any therapy. Six months afterwards, she developed multiple, asymptomatic purpura-like plaques with prominent teleangectasias on her right chest wall, continuous to the previous surgical scar and on her ipsilateral abdomen. Skin biopsy showed aggregates of atypical cells admixed with erythrocyte thrombi within dilated dermal lymphatic vessels. SR of the cutaneous lesions occurred within 6 months and persisted at the 15 months follow-up in the absence of therapy, whilst no signs of internal relapse were observed. Immunohistochemically, the estrogen-negative, CK7-positive, C-erb B2-positive intralymphatic metastases were associated with extensive infiltration of CD8-positive cytototoxic T lymphocytes. Factors that may have precluded the… Read more

    - greenmedinfo

    PMID:  Surg Case Rep. 2020 May 11 ;6(1):100. Epub 2020 May 11. PMID: 32394212 Abstract Title:  Spontaneous regression of advanced transverse colon cancer with remaining lymph node metastasis. Abstract:  BACKGROUND: The observation of spontaneous regression (SR) has been well documented for many cancer types, including renal cell carcinoma, non-Hodgkin's lymphoma, leukemia, neuroblastoma, and malignant melanoma. However, the SR frequency in colorectal cancer is very rare. Therefore, the accumulation of SR colorectal cancer cases might contribute to find the regression mechanism.CASE PRESENTATION: A 67-year-old woman received colonoscopy due to being positive for fecal occult blood testing and was diagnosed as having a transverse colon cancer at a local hospital. She was admitted to our institution for surgical treatment of the colon cancer. The colonoscopy revealed a type 2 tumor of 13 mm in diameter at the hepatic flexure of the transverse colon. The enhanced computed tomography (CT) showed an enlarged lymph node in the intermediate lymph node region. The 18F-fluorodeoxyglucose positron emission tomography/CT showed no abnormal accumulation on the transverse colon; however, anabnormal accumulation was found at the enlarged lymph node. The patient was preoperatively diagnosed as having advanced transverse colon cancer with lymph node metastasis and underwent laparoscopic right hemicolectomy with… Read more

    - greenmedinfo

    PMID:  Dig Endosc. 2020 May 16. Epub 2020 May 16. PMID: 32416608 Abstract Title:  Spontaneous regression of mismatch repair-deficient colorectal cancers: Case series. Abstract:  Spontaneous regression (SR) has been reported in various malignant tumors. However, SR in colorectal cancer (CRC) is particularly rare and the mechanism remains unclear. We here report three cases of CRCs displaying SR, which were experienced at two institutions. Intriguingly, all of these cases displayed the common endoscopic characteristics; superficial elevated lesion accompanied by a central depression (0-IIa + IIc, in the Paris classification), with a nonpolypoid growth, located in the ascending colon. Furthermore, immunohistology of biopsy specimens revealed the lack of DNA mismatch repair proteins within the CRC lesions, suggesting that these were mismatch repair-deficient (dMMR) CRCs. One of the major features of dMMR cancers is an increase in the number of tumor-infiltrating lymphocytes. Thus, the dMMR phenotype might be associated with SR of CRCs through the activation of anti-tumor host immune responses. read more Read more

    - greenmedinfo

    PMID:  Cancer Discov. 2020 Oct ;10(10):1489-1499. Epub 2020 Jul 20. PMID: 32690541 Abstract Title:  Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer. Abstract:  Before squamous cell lung cancer develops, precancerous lesions can be found in the airways. From longitudinal monitoring, we know that only half of such lesions become cancer, whereas a third spontaneously regress. Although recent studies have described the presence of an active immune response in high-grade lesions, the mechanisms underpinning clinical regression of precancerous lesions remain unknown. Here, we show that host immune surveillance is strongly implicated in lesion regression. Using bronchoscopic biopsies from human subjects, we find that regressive carcinomalesions harbor more infiltrating immune cells than those that progress to cancer. Moreover, molecular profiling of these lesions identifies potential immune escape mechanisms specifically in those that progress to cancer: antigen presentation is impaired by genomic and epigenetic changes,signaling is upregulated, and the immunomodulatoris downregulated. Changes appear intrinsic to the carcinomalesions, as the adjacent stroma of progressive and regressive lesions are transcriptomically similar. SIGNIFICANCE: Immune evasion is a hallmark of cancer. For the first time, this study identifies mechanisms by which precancerous lesions evade immune detection during the earliest stages of carcinogenesis and forms… Read more

    - greenmedinfo

    PMID:  Hepatology. 2020 Aug 2. Epub 2020 Aug 2. PMID: 32740961 Abstract Title:  Spontaneous Regression of HCC- When the Immune System Stands Up to Cancer. Abstract:  Spontaneous regression of cancer is rare and has been observed mostly in immunogenic cancers like melanoma. A few cases of spontaneous regression of hepatocellular carcinoma (HCC) have been reported, but the mechanisms of regression have not been elucidated. Here, we report a patient with advanced HCC who experienced spontaneous regression of her tumor and present evidence for a putative immune-mediated mechanism for tumor regression. read more Read more

    - greenmedinfo

    PMID:  BMC Pulm Med. 2020 Aug 6 ;20(1):209. Epub 2020 Aug 6. PMID: 32762670 Abstract Title:  Spontaneous regression of ALK fusion protein-positive non-small cell lung carcinoma: a case report and review of the literature. Abstract:  BACKGROUND: ALK-rearrangement is observed inread more Read more

    - greenmedinfo

    PMID:  J Interferon Cytokine Res. 2020 Aug ;40(8):406-417. PMID: 32813603 Abstract Title:  Lycopene Alleviates Hepatic Hypoxia/Reoxygenation Injury Through Nrf2/HO-1 Pathway in AML12 Cell. Abstract:  [Figure: see text] Lycopene (lyc) has an effect on preventing cancer, yet its effects on hypoxia/reoxygenation (H/R) injury remained obscure. The study aimed at discovering its role in preventing hepatic cells against H/R injury. Hepatic cells were incubated in hypoxia incubator to simulate ischemia/reperfusion injury. Cell viability was detected using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay after Lycopene treatment with or without ML385 (nuclear factor erythroid 2-related factor 2 [Nrf2] inhibitor). Lactate dehydrogenase (LDH) and malondialdehyde (MDA) content were detected. Cellular cytokine (tumor necrosis factor-α, TNF-α; interleukin-6, IL-6) levels were measured using enzyme-linked immunosorbent assay (ELISA). Hepatic cell apoptosis and cellular reactive oxygen species (ROS) content was detected by flow cytometry. Nrf2 transfer was observed using immunofluorescence staining. Nrf2 and heme oxygenase-1 (HO-1) expressions were detected with quantitative real-time polymerase chain reaction and western blot as needed. In hepatic cells, after H/R, the viability was dropped, TNF-α and IL-6 levels and LDH and MDA content were increased, with high apoptosis rate and ROS content. Lycopene led to a reversedeffect, with promotion on Nrf2 transfer from cytoplasm into nucleus… Read more

    - greenmedinfo

    PMID:  Food Chem Toxicol. 2020 Nov ;145:111688. Epub 2020 Aug 15. PMID: 32810585 Abstract Title:  Lycopene ameliorates chronic stress-induced hippocampal injury and subsequent learning and memory dysfunction through inhibiting ROS/JNK signaling pathway in rats. Abstract:  The natural carotenoid lycopene (LYC) has strong antioxidant and neuroprotective capacities. This study investigated the effects and mechanisms of LYC on chronic stress-induced hippocampal lesions and learning and memory dysfunction. Rats were administered LYC and/or chronic restraint stress (CRS) for 21 days. Morris water maze results demonstrated that LYC prevented CRS-induced learning and memory dysfunction. Histopathological staining and transmission electron microscopy observation revealed that LYC ameliorated CRS-induced hippocampal microstructural and ultrastructural damage. Furthermore, LYC alleviated CRS-induced oxidative stress by reducing reactive oxygen species (ROS) production and enhancing antioxidant enzyme activities. LYC also improved CRS-induced hippocampal mitochondrial dysfunction by recovering mitochondrial membrane potential, and complex I (NADH dehydrogenase) and II (succinate dehydrogenase) activities. Moreover, LYC reduced CRS-induced apoptosis via the mitochondrial apoptotic pathway, and decreased the number of terminal deoxynucleotidyl transferase dUTP nick-end-labeled positive cells. Additionally, western blot analysis demonstrated that LYC inhibited CRS-induced activation of the c-Jun N-terminal kinase (JNK) signaling pathway. Correlation analysis indicated that ROS levels, JNK activation, and the mitochondrial apoptotic pathway… Read more

    - Sayer Ji

    This article is copyrighted by GreenMedInfo LLC, 2020Visit our Re-post guidelines We gathered, around the world (all continents), to celebrate the health and the power of the human body on Oct 16, 2020! This was the main, Miami-based livestream and the schedule of the event: read more Read more

    - greenmedinfo

    PMID:  Neurochem Int. 2020 Nov ;140:104823. Epub 2020 Aug 20. PMID: 32827559 Abstract Title:  Lycopene - A pleiotropic neuroprotective nutraceutical: Deciphering its therapeutic potentials in broad spectrum neurological disorders. Abstract:  Lycopene is a naturally occurring carotenoid found abundantly in red fruits and vegetables. Myriads of literature documented potential health benefits of lycopene, owing to its sublime capacity of suppressing oxidative stress, inflammation, and modulation of various cell survival pathways. Due to its lipophilic nature, lycopene can reach brain adequately by traversing the blood-brain barrier thereby extending it's promising therapeutic benefits in neurological disorders. Lycopene efficiently assists in restoring the characteristic behavioural and pathophysiological changes associated with neurodegenerative disorders, epileptic conditions, aging, subarachnoid hemorrhage, spinal cord injury, and neuropathy. The detrimental impacts of environmental neurotoxins on brain and neuropathological consequences of consumption of high-lipid diet can also be mitigated by lycopene. Apart from its high antioxidant potency, lycopene confers neuroprotection by preventing proteinopathies, neuroinflammation, apoptosis, cerebral edema, and synaptic dysfunction. This review provides a lucid idea on the potential multi-faceted benefits of lycopene in disorders of the central nervous system and elucidates the molecular mechanisms and pathways of its action. read more Read more

    - greenmedinfo

    PMID:  Int J Vitam Nutr Res. 2020 Aug 28:1-8. Epub 2020 Aug 28. PMID: 32856544 Abstract Title:  Lycopene hampers lung injury due to skeletal muscle ischemia-reperfusion in rat model. Abstract:  This study investigates lycopene's preventive efficacy in skeletal muscle ischemia-reperfusion (I/R) induced lung injury. Thirty-two rats were randomly assigned to control group, lycopene group, I/R group and I/R + lycopene group. In the lycopene and I/R + lycopene groups, the rats initially received 10 mg/kg/day lycopene orally for 15 days. Then, dissection around the abdominal aorta was performed in all rats under general anesthesia. The aorta was clamped at the infrarenal level in the I/R group andI/R + lycopene group for two hours before two hours of reperfusion. The mean serum levels of malondialdehyde (53.0 ± 20.14 nmol/mL) and superoxide dismutase (1.03 ± 0.16 U/mL) were higher and lower in the I/R group than the other three groups, respectively (p read more Read more

    - greenmedinfo

    PMID:  In Vivo. 2020 Sep-Oct;34(5):3013-3021. PMID: 32871845 Abstract Title:  Tomato Juice Consumption Could Improve Breast Skin Adverse Effects of Radiotherapy in Breast Cancer Patients. Abstract:  BACKGROUND/AIM: We investigated the beneficial effects of drinking tomato juice (TJ) rich in antioxidant carotenoids on irradiated skin following radiotherapy (RT) in breast cancer patients.PATIENTS/METHODS: Twenty-three patients agreed to drink TJ (160 g/day for six months) after the completion of RT. Early and late adverse events (AEs) of irradiated skin were evaluated according to the Common Terminology Criteria for AEs and the European Organization for Research and Treatment of Cancer Global Cosmetic Rating System, respectively.RESULTS: With regard to early AEs, acute radiodermatitis of grade 1 was observed in most patients (22/23) at the end of RT. However, the grade of radiodermatitis rapidly changed to 0, 1 month after RT and starting TJ consumption. With regard to late AEs, most patients were in good or excellent dermal condition.CONCLUSION: TJ consumption could help in relieving and recovering from early AEs and decreasing the severity of late AEs of irradiated skin. read more Read more

    - greenmedinfo

    PMID:  J Food Sci. 2020 Oct ;85(10):3552-3561. Epub 2020 Sep 4. PMID: 32885410 Abstract Title:  Lycopene protects neuroblastoma cells against oxidative damage via depression of ER stress. Abstract:  Lycopene is a pigment derived from tomatoes and other red fruits, and has potent antioxidant and antitumor effects. However, its potential role in alleviating oxidative damage in neuronal cells is not well defined. In this study, we investigated the effects of lycopene on HO-induced damage in neuroblastoma cells, as well as the underlying mechanisms. Exposure to HOmarkedly decreased the viability of SH-SY5Y cells and increased LDH release, both of which were reversed by lycopene pretreatment. Lycopene also ameliorated HO-induced damage and reduced the expression of apoptotic markers, such as Bcl-2, Bax, and cleaved caspase 3. In addition, the HO-induced oxidative markers, including MDA, 8-OHdG, and protein carbonyls, were also downregulated by lycopene. Exogenous HOactivated the GRP78/PERK/eIF2α signaling pathway, which was inhibited by pretreatment with lycopene. Finally, lycopene significantly ameliorated ER stress-induced activation and nuclear translocation of CHOP. Overexpression of CHOP markedly reversed the antiapoptotic effects of lycopene, indicating that it is essential for thelatter's protective effects. Taken together, lycopene protects neuroblastoma cells from oxidative stress and ER stress-induced damage by inhibiting the… Read more

    - greenmedinfo

    n/a PMID:  Exp Anim. 2020 Sep 11. Epub 2020 Sep 11. PMID: 32921696 Abstract Title:  The effect of a natural molecule in ovary ischemia reperfusion damage: does lycopene protect ovary? Abstract:  Ovarian ischemia is a gynecological emergency case that occurs as a result of ovarian torsion. Oxidative stress plays a central role in the development of ischemia/reperfusion (IR) injuries. Lycopene (LYC) is a lipophilic, natural carotenoid well known for its antioxidant properties. This study provides information on the potential applications of lycopene. The Wistar Albino rats were distributed into six groups: Sham group [only a laparotomy was performed], Control group [laparotomy and intraperitoneal dissolvent (olive oil)], IR group , IR + olive oil group, IR+LYC 2.5 mg/kg/dose, intraperitoneal group, IR+LYC 5 mg/kg/dose intraperitoneal group. Evaluated in terms of histopathological changes, tissue malondialdehyde levels (MDA), ovarian expressions of phosphorylated nuclear factor-kappa B (p-NF-κB) and the TUNEL method was utilized to show apoptosis of ovarian tissue. There was a significant decrease in MDA, p-NF-κB values and the proportion of apoptotic cells assessed by TUNEL compared to the group that did not receive intraperitoneal LYC in rat injury with IR damage (p Read more

    - greenmedinfo

    PMID:  J Agric Food Chem. 2020 Oct 14 ;68(41):11468-11479. Epub 2020 Oct 5. PMID: 32962341 Abstract Title:  Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1α-Induced PPARα/PPARγ/FXR/LXR System. Abstract:  Di(2-ethylhexyl) phthalate (DEHP) is a widespread pollutant that badly affects animals and human health. Lycopene (LYC) has been used as a dietary supplement that has effective antioxidant and antiobesity functions. The present goal was to understand the molecular mechanisms of LYC preventing DEHP-induced lipid metabolism of the liver. The mice were intragastrically administered with LYC (5 mg/kg) and/or DEHP (500 mg/kg or 1000 mg/kg). Here, we found that LYC attenuated DEHP-caused hepatic histopathological lesions including steatosis. Hematological and biochemical analyses revealed that LYC ameliorated DEHP-caused liver function and lipid metabolism disorders. DEHP caused lipid metabolism disorders via activating the peroxisome proliferator activated receptorα/γ (PPARα/γ) signal transducer and Farnesoid X receptor (FXR)/liver X receptor (LXR) signaling pathway. As a major regulator of lipid metabolism, hypoxia-inducible factor-1α (HIF-1α) system was elevated with increased fatty degeneration under DEHP exposure. However, LYC could decrease the levels of HIF-1α/PPARα/PPARγ/FXR/LXR signaling pathway-related factors. Our research indicated that LYC could prevent DEHP-induced lipid metabolism disorders via inhibiting the HIF-1α-mediated PPARα/PPARγ/FXR/LXR system. This study may provide a… Read more

    - greenmedinfo

    PMID:  Front Pharmacol. 2020 ;11:1306. Epub 2020 Aug 21. PMID: 32982734 Abstract Title:  Anti-Cancer Effects of Lycopene in Animal Models of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis. Abstract:  Introduction: Globally, hepatocellular carcinoma (HCC) is the sixth most diagnosed cancer and the third important cause of cancer-related death. As there are only two targeted drugs for the treatment of advanced HCC-that merely extend survival by a few months-the need for alternative treatments is inevitable. Lycopene, a carotenoid that is known to be most abundant in red tomatoes and tomato-based products, has been investigated for its anticancer activity in various types of cancers including HCC. This review was conducted to evaluate the effects of lycopene on HCC from animal models to pave the way for further clinical studies.Methods: Electronic databases and search engines including PubMed, EMBASE, and Google Scholar were searched for original records addressing the anticancer effect of lycopene in animal models of HCC. Data were extracted using a format prepared in Microsoft Excel and exported to Stata 15.0 for analyses. A meta-analysis was performed using a random-effects model at a 95% confidence level for the outcome measures: tumor incidence, number, and growth (tumor volume and size). The presence of… Read more

    - greenmedinfo

    PMID:  Int J Mol Sci. 2020 Sep 27 ;21(19). Epub 2020 Sep 27. PMID: 32992481 Abstract Title:  Potential Role of Lycopene in the Prevention of Postmenopausal Bone Loss: Evidence from Molecular to Clinical Studies. Abstract:  Osteoporosis is a metabolic bone disease characterized by reduced bone mineral density, which affects the quality of life of the aging population. Furthermore, disruption of bone microarchitecture and the alteration of non-collagenous protein in bones lead to higher fracture risk. This is most common in postmenopausal women. Certain medications are being used for the treatment of osteoporosis; however, these may be accompanied by undesirable side effects. Phytochemicals from fruits and vegetables are a source of micronutrients for the maintenance of bone health. Among them, lycopene has recently been shown to have a potential protective effect against bone loss. Lycopene is a lipid-soluble carotenoid that exists in both all-and-configurations in nature. Tomato and tomato products are rich sources of lycopene. Several human epidemiological studies, supplemented by in vivo and in vitro studies, have shown decreased bone loss following the consumption of lycopene/tomato. However, there are still limited studies that have evaluated the effect of lycopene on the prevention of bone loss in postmenopausal women. Therefore, the… Read more

    - greenmedinfo

    PMID:  Saudi J Biol Sci. 2020 Oct ;27(10):2733-2746. Epub 2020 Jun 23. PMID: 32994733 Abstract Title:  Anti-obesity potential ofseed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats. Abstract:  Present research explored the anti-obesity effect ofseed oil extract and lycopene (LYC). Forty eight male Sprauge Dawely rats were divided equally into 6 groups. GroupΙ (C) served as control, group ΙΙ (MC) was givenseed oil extract (800 mg/kg b.wt) for 8 weeks, group ΙΙΙ (LC) was given (20 mg/kg b.wt) LYC for 8 weeks, group ΙV (O) received high fat diet (HFD) for 20 weeks, group Ѵ (MO), was given HFD for 20 weeks and received (800 mg/kg b.wt)seed oil extract for last 8 weeks and group ѴΙ (LO), received HFD for 20 weeks and was given (20 mg/kg b.wt) LYC for last 8 weeks. Hematology, lipid peroxidation and antioxidants, non-esterified fatty acids (NEFA), glucose, lipid profile, serum liver and kidney biomarkers, inflammatory markers, leptin, resistin andheart fatty acid binding protein (HFABP) were determined. Also histopathology for liver, kidney and aorta were performed besides immunohistochemistry (IHC) for aortic inducible nitric oxide synthase (iNOS). Administration ofseed oil extract and LYC significantly ameliorated the HFD induced hematological and metabolic perturbations as well as reduced leptin and resistin. Both treatments… Read more

    - greenmedinfo

    PMID:  Indian J Clin Biochem. 2020 Oct ;35(4):474-481. Epub 2019 Sep 13. PMID: 33013018 Abstract Title:  The Nephroprotective Effect of Lycopene on Renal Ischemic Reperfusion Injury: A Mouse Model. Abstract:  Acute kidney injury (AKI) is characterized by fast decline in renal function within a short period of time. Renal ischemic-reperfusion (I-R) injury is the main cause of AKI. This study aims to investigate the possible nephroprotective effect of lycopene on renal ischemic-reperfusion injury in mice model. Forty Swiss Albino adult male mice were randomly allocated onto one of the four study groups: sham group: mice had median laparotomy under anesthesia with no procedures performed, renal tissues and blood samples were collected. ischemic-reperfusion group (I-R-control): mice underwent median laparotomy under anesthesia, followed by 30 min bilateral renal ischemia. Renal tissues and blood samples were collected after 2 h from reperfusion. Vehicle-treated group: mice were pretreated with intra 1% dimethyl sulfoxide 30 min before inducing ischemia. Lycopene-treated group: mice were pretreated with 10 mg/kg intraperitoneal injection of lycopene 30 min before inducing renal ischemia. Renal tissues, and blood samples were collected after 2 h from reperfusion. Blood and tissue samples were collected to look for evidence of inflammation and necrosis. Blood urea nitrogen, serum creatinine as well as… Read more

    - greenmedinfo

    PMID:  J Nutr Biochem. 2020 Oct 8:108523. Epub 2020 Oct 8. PMID: 33039582 Abstract Title:  Effects of lycopene on skeletal muscle fiber type and high fat diet induced oxidative stress. Abstract:  Increasing studies report that many natural products can participate in formation of muscle fibers. This study aimed to investigate the effect of lycopene on skeletal muscle fiber type in vivo and in vitro. C2C12 myoblasts were used in vitro study, and the concentration of lycopene was 10μM; In vivo, eight weeks old male C57/BL6 mice were used and divided into four groups (n=8): 1) ND: normal-fat diet; 2) ND+Lyc: normal-fat diet mixed with 0.33% w/w lycopene; 3) HFD: high-fat diet; and 4) HFD+Lyc: high-fat diet mixed with 0.33% w/w lycopene. The mice tissue samples were collected after 8 weeks feeding. We found that lycopene supplementation enhanced the protein expression of slow-twitch fiber, succinate dehydrogenase, and malic dehydrogenase enzyme activities, whereas lycopene reduced the protein expression of fast-twitch fibers, lactate dehydrogenase, pyruvate kinase enzymeactivities. Moreover, lycopene can promote skeletal muscle triglyceride deposition, enhanced the mRNA expression of genes related to lipid synthesis, reduced the mRNA expression of genes related to lipolysis. And high fat diet induced dyslipidemia and oxidative stress… Read more

    - greenmedinfo

    PMID:  Diabetes Metab Syndr Obes. 2020 ;13:3117-3135. Epub 2020 Sep 7. PMID: 32982345 Abstract Title:  Lycopene Improves the Metformin Effects on Glycemic Control and Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats. Abstract:  Introduction: Oxidative stress and exacerbated generation of advanced glycation end products (AGEs) participate in the onset of diabetic complications. Lycopene is a potent antioxidant; evidence accounts for its ability to mitigate diabetic disturbances, including the deleterious events of advanced glycation. Therefore, this carotenoid has emerged as a candidate to be used in combination with antidiabetic drugs, such as metformin, attempting to counteract the glycoxidative stress. This study investigated the effects of the treatments with lycopene or metformin, alone or in combination, on glycoxidative stress biomarkers and antioxidant defenses in diabetic rats.Methods: Streptozotocin-induced diabetic rats were treated for 35 days with lycopene (45 mg/kg) or metformin (250 mg/kg), alone or as mixtures in yoghurt. Plasma levels of glucose, triglycerides, cholesterol, thiobarbituric acid reactive substances and protein carbonyl groups (biomarkers of oxidative damage), fluorescent AGEs (biomarkers of advanced glycation), and paraoxonase 1 activity (antioxidant enzyme) were assessed. Changes in the hepatic and renal levels of glycoxidative damage biomarkers and the activities of antioxidant enzymes were investigated.Results: The combination of… Read more

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